Academic Journal
Oligomers of styrene are not endocrine disruptors
| Τίτλος: | Oligomers of styrene are not endocrine disruptors |
|---|---|
| Συγγραφείς: | Heinz-Peter, Gelbke, Marcy, Banton, Christian, Block, Gordon, Dawkins, Edgar, Leibold, Mark, Pemberton, Atsunobu, Sakoda, Atsushi, Yasukawa |
| Πηγή: | Critical Reviews in Toxicology. 48:471-499 |
| Στοιχεία εκδότη: | Informa UK Limited, 2018. |
| Έτος έκδοσης: | 2018 |
| Θεματικοί όροι: | Male, Endocrine Glands, Food Packaging, Animals, Humans, Polystyrenes, Reproducibility of Results, Female, Endocrine Disruptors, 01 natural sciences, 0105 earth and related environmental sciences |
| Περιγραφή: | Oligomers of styrene have been identified in polystyrene (PS) polymer samples intended for food packaging. Such oligomers contribute to nonintentionally added substances (NIAS) that may migrate into food or food simulants and therefore have to be assessed for the potential risk to health. No oligomers larger than dimers and trimers of styrene have been found to be present in PS. Some in vivo and in vitro information indicative of an endocrine activity for some specific oligomers suggest concerns for their potential for endocrine disruption in humans. Data on endocrine activity available from in vitro and in vivo screening approaches and from non-guideline studies in experimental animals were evaluated. The different test methods were classified according to the OECD Conceptual Framework for Testing and Assessment of Endocrine Disruptors (OECD) and the ranking system of Borgert et al. proposed in 2014. The quality and reliability of each study is further assessed by professional judgment. The integration of the total information supports the conclusion that neither specific oligomers, nor their mixtures, potentially migrating into food are endocrine disruptors according to the definition of EFSA and WHO/IPCS. |
| Τύπος εγγράφου: | Article Other literature type |
| Γλώσσα: | English |
| ISSN: | 1547-6898 1040-8444 |
| DOI: | 10.1080/10408444.2018.1447547 |
| DOI: | 10.6084/m9.figshare.6134006.v2 |
| DOI: | 10.6084/m9.figshare.6134006 |
| DOI: | 10.6084/m9.figshare.6134006.v1 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/29648919 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....b7cab73e5f98d884b6687e4eab27eb77 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 15476898 10408444 |
|---|---|
| DOI: | 10.1080/10408444.2018.1447547 |