Academic Journal
Preventive effect of sensorimotor exercise and resistance training on chemotherapy-induced peripheral neuropathy: a randomised-controlled trial
| Title: | Preventive effect of sensorimotor exercise and resistance training on chemotherapy-induced peripheral neuropathy: a randomised-controlled trial |
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| Authors: | Wolfgang Wick, Karen Steindorf, Andreas Schneeweiss, Jana Müller, Georg Martin Haag, Markus Weiler, Joachim Wiskemann |
| Source: | Br J Cancer |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Adult, Male, Peripheral Nervous System Diseases, Antineoplastic Agents, Resistance Training, Middle Aged, Article, 3. Good health, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Quality of Life, Humans, Patient Compliance, Female [MeSH], Peripheral Nervous System Diseases/prevention, Antineoplastic Agents/adverse effects [MeSH], Aged [MeSH], Neurological manifestations, Adult [MeSH], Physical Therapy Modalities/psychology [MeSH], Resistance Training/methods [MeSH], Humans [MeSH], Breast cancer, Lifestyle modification, Treatment Outcome [MeSH], Quality of Life/psychology [MeSH], Middle Aged [MeSH], Randomized controlled trials, Quality of life, Male [MeSH], Patient Compliance/statistics, Peripheral Nervous System Diseases/chemically induced [MeSH], Female, Physical Therapy Modalities, Aged |
| Description: | Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common, unpleasant and usually long-lasting side effect of neurotoxic chemotherapeutic agents. This study aimed to investigate the preventive potential of sensorimotor- (SMT) and resistance training (RT) on CIPN. Methods Patients (N = 170) were randomised to SMT, RT or usual care (UC). Both exercise groups trained 3×/week for a total of 105 min/week during neurotoxic chemotherapy (mean length: 20 weeks). Before and 3 weeks after neurotoxic chemotherapy, CIPN signs/symptoms were assessed via Total Neuropathy Score (TNSr; primary endpoint) and EORTC QLQ-CIPN15 questionnaire. In addition, balance (centre of pressure), muscle strength (isokinetic), quality of life (QoL, EORTC QLQ-C30) and relative chemotherapy dose intensity (RDI) were investigated. The follow-up period covered 6 months after the end of chemotherapy. Results Intention-to-treat analyses (N = 159) revealed no differences regarding CIPN signs/symptoms. Exploratory per-protocol analyses (minimum training attendance rate 67%; N = 89) indicated that subjectively perceived sensory symptoms in the feet increased less during chemotherapy in the adherent exercisers (pooled group: SMT+RT) than in the UC group (−8.3 points (−16.1 to −0.4); P = 0.039, ES = 1.27). Furthermore, adherent exercisers received a higher RDI (96.6 ± 4.8 vs. 92.2 ± 9.4; P = 0.045), showed a better course of muscular strength (+20.8 Nm (11.2–30.4); P P = 0.005, ES = 0.64). During follow-up, CIPN signs/symptoms persisted in all groups. Conclusions This study demonstrates that SMT and/or RT alleviate subjectively perceived sensory CIPN symptoms in the feet and other clinically relevant cancer therapy-related outcomes, if an appropriate training stimulus is achieved. Clinical trial registration NCT02871284. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/s41416-021-01471-1 |
| Access URL: | https://www.nature.com/articles/s41416-021-01471-1.pdf https://pubmed.ncbi.nlm.nih.gov/34226683 https://pubmed.ncbi.nlm.nih.gov/34226683/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476560 https://www.nature.com/articles/s41416-021-01471-1 https://www.nature.com/articles/s41416-021-01471-1.pdf https://repository.publisso.de/resource/frl:6442880 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Accession Number: | edsair.doi.dedup.....b2d2859133e5f246b17be727a4060ed3 |
| Database: | OpenAIRE |
| ISSN: | 15321827 00070920 |
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| DOI: | 10.1038/s41416-021-01471-1 |