Academic Journal
Immune Cells in Subretinal Wound Healing and Fibrosis
| Τίτλος: | Immune Cells in Subretinal Wound Healing and Fibrosis |
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| Συγγραφείς: | Manon Szczepan, María Llorián-Salvador, Mei Chen, Heping Xu |
| Συνεισφορές: | Institut Català de la Salut, [Szczepan M, Chen M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. [Llorián-Salvador M] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Xu H] The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom. Aier Institute of Optometry and Vision Science, Changsha, China, Vall d'Hebron Barcelona Hospital Campus |
| Πηγή: | Front Cell Neurosci Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname Frontiers in Cellular Neuroscience, Vol 16 (2022) Szczepan, M, Llorián-Salvador, M, Chen, M & Xu, H 2022, 'Immune cells in subretinal wound healing and fibrosis', Frontiers in Cellular Neuroscience, vol. 16, 916719. https://doi.org/10.3389/fncel.2022.916719 |
| Στοιχεία εκδότη: | Frontiers Media SA, 2022. |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | retina, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::inmunidad celular, Neurosciences. Biological psychiatry. Neuropsychiatry, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular, 03 medical and health sciences, Immunitat cel·lular, 0302 clinical medicine, ANATOMÍA::órganos de los sentidos::ojo::retina, DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis, ANATOMY::Sense Organs::Eye::Retina, innate immunity, age-related macular degeneration, macular fibrosis, Retina - Patogènesi, Other subheadings::Other subheadings::Other subheadings::/pathology, DISEASES::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration, proliferative vitroretinopathy, adaptive immunity, 3. Good health, inflammation, Otros calificadores::Otros calificadores::Otros calificadores::/patología, ENFERMEDADES::oftalmopatías::enfermedades de la retina::degeneración retiniana::degeneración macular, ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis, Degeneració macular, RC321-571, Neuroscience |
| Περιγραφή: | The subretinal space is devoid of any immune cells under normal conditions and is an immune privileged site. When photoreceptors and/or retinal pigment epithelial cells suffer from an injury, a wound healing process will be initiated. Retinal microglia and the complement system, as the first line of retinal defense, are activated to participate in the wound healing process. If the injury is severe or persists for a prolonged period, they may fail to heal the damage and circulating immune cells will be summoned leading to chronic inflammation and abnormal wound healing, i.e., subretinal or intraretinal fibrosis, a sight-threatening condition frequently observed in rhematogenous retinal detachment, age-related macular degeneration and recurrent uveoretinitis. Here, we discussed the principles of subretinal wound healing with a strong focus on the conditions whereby the damage is beyond the healing capacity of the retinal defense system and highlighted the roles of circulating immune cells in subretinal wound healing and fibrosis. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2022.916719 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/35755781 https://hdl.handle.net/11351/8797 https://doaj.org/article/fe56faf95ab54777a97d082f3b5e4eea https://pure.qub.ac.uk/en/publications/38ab5d0a-ca5c-4446-ad4a-465de8db15cf |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....b05bdae28af62b9cc30fa3ba90fbabd5 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 16625102 |
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| DOI: | 10.3389/fncel.2022.916719 |