Academic Journal
Experimental Substantiation of Cultural Technologies Introduction into Manufacturing of Anti-Rabies Immunoglobulin
| Τίτλος: | Experimental Substantiation of Cultural Technologies Introduction into Manufacturing of Anti-Rabies Immunoglobulin |
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| Συγγραφείς: | E. G. Abramova, S. V. Generalov, Zh. V. Matveeva, I. M. Zhulidov, A. K. Nikiforov, A. V. Komissarov |
| Πηγή: | Проблемы особо опасных инфекций, Vol 0, Iss 2, Pp 95-101 (2016) |
| Στοιχεία εκδότη: | Russian Research Anti-Plague Institute Microbe, 2016. |
| Έτος έκδοσης: | 2016 |
| Θεματικοί όροι: | cell culture, вирус бешенства, бешенство, rabies, культура клеток, Infectious and parasitic diseases, RC109-216, производственный регламент, immunization, ультрафильтрация, 3. Good health, ultra-filtration, стандартная операционная процедура, 03 medical and health sciences, 0302 clinical medicine, антирабический иммуноглобулин, иммунизация, rabies virus, фармакопейная статья, anti-rabies immunoglobulin, standard operational procedure, master formula, pharmacopoeial monograph |
| Περιγραφή: | The review provides information on the major outcomes of research and development work, performed within the frames of the Federal Target Program “National system of chemical and biological safety” (2009-2014), aimed at elaboration and introduction of cultural techniques into the manufacturing of anti-rabies immunoglobulin. Described are the key phases in methodology engineering, deployed for the large-scale cultivation of fixed rabies virus, concentration of cultural liquid, quantitation of rabies virus using PCR, and immunization of producers. Obtained pilot batches of the enhanced anti-rabies immunoglobulin, complying with normative requirements to commercial formulations, testify to the effectiveness of the developed biotechnological and methodological procedures, as well as of the designed engineering-manufacturing project documentation. |
| Τύπος εγγράφου: | Article Other literature type |
| ISSN: | 0370-1069 |
| DOI: | 10.21055/0370-1069-2016-2-95-101 |
| Σύνδεσμος πρόσβασης: | https://journal.microbe.ru/jour/article/download/315/312 https://doaj.org/article/969aa94ab177438d92e6d3519d78b72a https://journal.microbe.ru/jour/article/view/315/312 https://cyberleninka.ru/article/n/eksperimentalnoe-obosnovanie-vnedreniya-kulturalnyh-tehnologiy-v-proizvodstvo-antirabicheskogo-immunoglobulina https://journal.microbe.ru/jour/article/download/315/312 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....adc28a4d0debae809c3e1958372899a9 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 03701069 |
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| DOI: | 10.21055/0370-1069-2016-2-95-101 |