Academic Journal
Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs
| Τίτλος: | Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs |
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| Συγγραφείς: | Dyan Ramekers, Heval Benav, Sjaak F. L. Klis, Huib Versnel |
| Συνεισφορές: | KNO Onderzoek, Brain |
| Πηγή: | J Assoc Res Otolaryngol |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2022. |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | Spiral Ganglion/physiology, Action Potentials/physiology, Guinea Pigs, Action Potentials, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Auditory nerve, Cochlear Nerve/physiology, Journal Article, Humans, Animals, Cochlear health, Neurodegeneration, Cochlear implant, Evoked Potentials, Cochlear Nerve, Hearing loss, Cochlear Implantation, Sensory Systems, Electric Stimulation, Cochlear Implants, Cochlear Implantation/methods, Otorhinolaryngology, Evoked Potentials, Auditory/physiology, eCAP, Evoked Potentials, Auditory, Spiral Ganglion, Research Article |
| Περιγραφή: | The electrically evoked compound action potential (eCAP) is a direct measure of the responsiveness of the auditory nerve to electrical stimulation from a cochlear implant (CI). CIs offer a unique opportunity to study the auditory nerve’s electrophysiological behavior in individual human subjects over time. In order to understand exactly how the eCAP relates to the condition of the auditory nerve, it is crucial to compare changes in the eCAP over time in a controlled model of deafness-induced auditory nerve degeneration. In the present study, 10 normal-hearing young adult guinea pigs were implanted and deafened 4 weeks later, so that the effect of deafening could be monitored within-subject over time. Following implantation, but before deafening, most examined eCAP characteristics significantly changed, suggesting increasing excitation efficacy (e.g., higher maximum amplitude, lower threshold, shorter latency). Conversely, inter-phase gap (IPG) effects on these measures – within-subject difference measures that have been shown to correlate well with auditory nerve survival – did not vary for most eCAP characteristics. After deafening, we observed an initial increase in excitability (steeper slope of the eCAP amplitude growth function (AGF), lower threshold, shorter latency and peak width) which typically returned to normal-hearing levels within a week, after which a slower process, probably reflecting spiral ganglion cell loss, took place over the remaining 6 weeks (e.g., decrease in maximum amplitude, AGF slope, peak area, and IPG effect for AGF slope; increase in IPG effect for latency). Our results suggest that gradual changes in peak width and latency reflect the rate of neural degeneration, while peak area, maximum amplitude, and AGF slope reflect neural population size, which may be valuable for clinical diagnostics. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1438-7573 |
| DOI: | 10.1007/s10162-022-00864-0 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/35948695 https://dspace.library.uu.nl/handle/1874/448188 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....a5d12b8dd456fb0959039277d0fea38d |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14387573 |
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| DOI: | 10.1007/s10162-022-00864-0 |