Academic Journal
The neural signature of psychomotor disturbance in depression
| Τίτλος: | The neural signature of psychomotor disturbance in depression |
|---|---|
| Συγγραφείς: | Florian Wüthrich, Stephanie Lefebvre, Vijay A. Mittal, Stewart A. Shankman, Nina Alexander, Katharina Brosch, Kira Flinkenflügel, Janik Goltermann, Dominik Grotegerd, Tim Hahn, Hamidreza Jamalabadi, Andreas Jansen, Elisabeth J. Leehr, Susanne Meinert, Igor Nenadić, Robert Nitsch, Frederike Stein, Benjamin Straube, Lea Teutenberg, Katharina Thiel, Florian Thomas-Odenthal, Paula Usemann, Alexandra Winter, Udo Dannlowski, Tilo Kircher, Sebastian Walther |
| Πηγή: | Mol Psychiatry Wüthrich, Florian; Lefebvre, Stephanie; Mittal, Vijay A; Shankman, Stewart A; Alexander, Nina; Brosch, Katharina; Flinkenflügel, Kira; Goltermann, Janik; Grotegerd, Dominik; Hahn, Tim; Jamalabadi, Hamidreza; Jansen, Andreas; Leehr, Elisabeth J; Meinert, Susanne; Nenadić, Igor; Nitsch, Robert; Stein, Frederike; Straube, Benjamin; Teutenberg, Lea; Thiel, Katharina; ... (2024). The neural signature of psychomotor disturbance in depression. Molecular psychiatry, 29(2), pp. 317-326. Nature Publishing Group 10.1038/s41380-023-02327-1 <http://dx.doi.org/10.1038/s41380-023-02327-1> |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2023. |
| Έτος έκδοσης: | 2023 |
| Θεματικοί όροι: | Male, Adult, Depressive Disorder, Major, Brain Mapping, Depression, Motor Cortex, Brain, 610 Medicine & health, Female [MeSH], 692/53, Adult [MeSH], Humans [MeSH], Nerve Net/physiopathology [MeSH], Depression/physiopathology [MeSH], Middle Aged [MeSH], Neural Pathways/physiopathology [MeSH], 59/36, 692/699/476/1414, Article, Brain/physiopathology [MeSH], Depressive Disorder, Major/physiopathology [MeSH], Male [MeSH], Psychomotor Disorders/etiology [MeSH], Motor Cortex/physiopathology [MeSH], Psychomotor Agitation/physiopathology [MeSH], Brain Mapping/methods [MeSH], Psychomotor Disorders/physiopathology [MeSH], Magnetic Resonance Imaging/methods [MeSH], article, Middle Aged, Magnetic Resonance Imaging, Neural Pathways, Humans, Female, Psychomotor Disorders, Nerve Net, Psychomotor Agitation |
| Περιγραφή: | Up to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time understanding of its pathophysiology is limited. In this study, we capitalized on a large sample of patients to examine the neural correlates of PmD in depression. This study included 820 healthy participants and 699 patients with remitted (n = 402) or current (n = 297) depression. Patients were further categorized as having psychomotor retardation, agitation, or no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between nodes of the cerebral motor network between the groups, including primary motor cortex, supplementary motor area, sensory cortex, superior parietal lobe, caudate, putamen, pallidum, thalamus, and cerebellum. Additionally, we examined network topology of the motor network using graph theory. Among the currently depressed 55% had PmD (15% agitation, 29% retardation, and 11% concurrent agitation and retardation), while 16% of the remitted patients had PmD (8% retardation and 8% agitation). When compared with controls, currently depressed patients with PmD showed higher thalamo-cortical and pallido-cortical connectivity, but no network topology alterations. Currently depressed patients with retardation only had higher thalamo-cortical connectivity, while those with agitation had predominant higher pallido-cortical connectivity. Currently depressed patients without PmD showed higher thalamo-cortical, pallido-cortical, and cortico-cortical connectivity, as well as altered network topology compared to healthy controls. Remitted patients with PmD showed no differences in single connections but altered network topology, while remitted patients without PmD did not differ from healthy controls in any measure. We found evidence for compensatory increased cortico-cortical resting-state functional connectivity that may prevent psychomotor disturbance in current depression, but may perturb network topology. Agitation and retardation show specific connectivity signatures. Motor network topology is slightly altered in remitted patients arguing for persistent changes in depression. These alterations in functional connectivity may be addressed with non-invasive brain stimulation. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-023-02327-1 |
| DOI: | 10.48350/189714 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38036604 https://boris.unibe.ch/189714/ https://repository.publisso.de/resource/frl:6501755 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....a5ac5c0a720fd4194eda0f9958002cc4 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14765578 13594184 |
|---|---|
| DOI: | 10.1038/s41380-023-02327-1 |