Bibliographic Details
| Title: |
Deep Brain Stimulation of Bilateral Centromedian Thalamic Nuclei in Pediatric Patients with Lennox-Gastaut Syndrome: An Institutional Experience |
| Authors: |
David Bonda, Katherine A. Kelly, Scott Boop, Abdullah H. Feroze, Stephanie C. Randle, Mike Bindschadler, Ahmad Marashly, James Owens, Jason Lockrow, Xiuhua Bozarth, Edward Novotny, Seth Friedman, Hannah E. Goldstein, Benjamin L. Grannan, Sharon Durfy, Jeffrey G. Ojemann, Andrew L. Ko, Jason S. Hauptman |
| Source: |
World Neurosurgery. 185:e631-e639 |
| Publisher Information: |
Elsevier BV, 2024. |
| Publication Year: |
2024 |
| Subject Terms: |
Male, Young Adult, Drug Resistant Epilepsy, Treatment Outcome, Adolescent, Lennox Gastaut Syndrome, Intralaminar Thalamic Nuclei, Deep Brain Stimulation, Humans, Female, Child, Retrospective Studies |
| Description: |
Surgical management of pediatric patients with nonlesional, drug-resistant epilepsy, including patients with Lennox-Gastaut syndrome (LGS), remains a challenge given the lack of resective targets in most patients and shows seizure freedom rates 60% reduction in seizure frequency after surgery, 1 patient experienced 10% reduction, and 1 patient showed no change. No children reported worsening seizure symptoms after surgery.Our study contributes to the sparse literature describing CMTN DBS for children with drug-resistant epilepsy from LGS. Our results suggest that CMTN DBS is a safe and effective therapeutic modality that should be considered as an alternative or adjuvant therapy for this challenging patient population. Further studies with larger patient populations are warranted. |
| Document Type: |
Article |
| Language: |
English |
| ISSN: |
1878-8750 |
| DOI: |
10.1016/j.wneu.2024.02.099 |
| Access URL: |
https://pubmed.ncbi.nlm.nih.gov/38403017 |
| Rights: |
Elsevier TDM |
| Accession Number: |
edsair.doi.dedup.....a0d055b2787dfd2a4a71e16128f4b9d0 |
| Database: |
OpenAIRE |