Academic Journal
The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression
| Τίτλος: | The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression |
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| Συγγραφείς: | Flinkenflügel, Kira, Gruber, Marius, Meinert, Susanne, Thiel, Katharina, Winter, Alexandra, Goltermann, Janik, Usemann, Paula, Brosch, Katharina, Stein, Frederike, Thomas-Odenthal, Florian, Wroblewski, Adrian, Pfarr, Julia-Katharina, David, Friederike S., Beins, Eva C., Grotegerd, Dominik, Hahn, Tim, Leehr, Elisabeth J., Dohm, Katharina, Bauer, Jochen, Forstner, Andreas J., Nöthen, Markus M., Jamalabadi, Hamidreza, Straube, Benjamin, Alexander, Nina, Jansen, Andreas, Witt, Stephanie H., Rietschel, Marcella, Nenadić, Igor, van den Heuvel, Martijn P., Kircher, Tilo, Repple, Jonathan, Dannlowski, Udo |
| Πηγή: | Mol Psychiatry Molecular psychiatry 29, 3151-3159 (2024). doi:10.1038/s41380-024-02577-7 Molecular Psychiatry |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, Adult, 0301 basic medicine, Multifactorial Inheritance, Female [MeSH], Multifactorial Inheritance/genetics [MeSH], 59/57, Adult [MeSH], Humans [MeSH], Nerve Net/physiopathology [MeSH], Depressive Disorder, Major/metabolism [MeSH], Depressive Disorder, Major/genetics [MeSH], Middle Aged [MeSH], Processing Speed [MeSH], 692/699/476/1414, Article, Brain/physiopathology [MeSH], Depressive Disorder, Major/physiopathology [MeSH], Male [MeSH], Nerve Net/metabolism [MeSH], Nerve Net/diagnostic imaging [MeSH], Brain/metabolism [MeSH], Magnetic Resonance Imaging/methods [MeSH], Tumor Necrosis Factor-alpha/metabolism [MeSH], 631/378, article, Neuropsychological Tests [MeSH], Neuropsychological Tests, Magnetic Resonance Imaging/methods, Nerve Net/metabolism, 03 medical and health sciences, 0302 clinical medicine, Brain/metabolism, Humans, Multifactorial Inheritance/genetics, Processing Speed, Tumor Necrosis Factor-alpha/metabolism, Depressive Disorder, Depressive Disorder, Major, Tumor Necrosis Factor-alpha, Brain, Major/genetics, Middle Aged, Magnetic Resonance Imaging, Female, Nerve Net |
| Περιγραφή: | Reduced processing speed is a core deficit in major depressive disorder (MDD) and has been linked to altered structural brain network connectivity. Ample evidence highlights the involvement of genetic-immunological processes in MDD and specific depressive symptoms. Here, we extended these findings by examining associations between polygenic scores for tumor necrosis factor-α blood levels (TNF-α PGS), structural brain connectivity, and processing speed in a large sample of MDD patients. Processing speed performance of n = 284 acutely depressed, n = 177 partially and n = 198 fully remitted patients, and n = 743 healthy controls (HC) was estimated based on five neuropsychological tests. Network-based statistic was used to identify a brain network associated with processing speed. We employed general linear models to examine the association between TNF-α PGS and processing speed. We investigated whether network connectivity mediates the association between TNF-α PGS and processing speed. We identified a structural network positively associated with processing speed in the whole sample. We observed a significant negative association between TNF-α PGS and processing speed in acutely depressed patients, whereas no association was found in remitted patients and HC. The mediation analysis revealed that brain connectivity partially mediated the association between TNF-α PGS and processing speed in acute MDD. The present study provides evidence that TNF-α PGS is associated with decreased processing speed exclusively in patients with acute depression. This association was partially mediated by structural brain connectivity. Using multimodal data, the current findings advance our understanding of cognitive dysfunction in MDD and highlight the involvement of genetic-immunological processes in its pathomechanisms. |
| Τύπος εγγράφου: | Article Other literature type |
| Γλώσσα: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-024-02577-7 |
| DOI: | 10.34734/fzj-2024-03555 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38693319 https://research.vu.nl/en/publications/3ca947ed-9539-4dfc-bc88-7e6616c75d05 https://doi.org/10.1038/s41380-024-02577-7 https://hdl.handle.net/1871.1/3ca947ed-9539-4dfc-bc88-7e6616c75d05 https://juser.fz-juelich.de/record/1026976 https://repository.publisso.de/resource/frl:6521043 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....a0868a4505fce42c55be085c38cf1366 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14765578 13594184 |
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| DOI: | 10.1038/s41380-024-02577-7 |