Academic Journal
Visualization of maturation of the corpus callosum during childhood and adolescence using T2 relaxometry
| Τίτλος: | Visualization of maturation of the corpus callosum during childhood and adolescence using T2 relaxometry |
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| Συγγραφείς: | Seung Koo Lee, Dong I. Kim, Dong J. Kim, Eung Yeop Kim, Hae-Jeong Park, Xavier Golay, Donghyun Kim, Jinna Kim, Eunhye Yoo |
| Συνεισφορές: | Eung Y. Kim, Dong-Hyun Kim, Dong I. Kim, Jinna Kim, Dong J. Kim, Seung-Koo Lee, Xavier Golay, Hae-Jeong Park, Eunhye Yoo, Kim, Dong Ik, Kim, Dong Joon, Kim, Eung Yeop, Kim, Jinna, Park, Hae Jeong, Yoo, Eun Hye, Lee, Seung Koo |
| Πηγή: | International Journal of Developmental Neuroscience. 25:409-414 |
| Στοιχεία εκδότη: | Wiley, 2007. |
| Έτος έκδοσης: | 2007 |
| Θεματικοί όροι: | Adult, Male, Corpus Callosum/anatomy & histology, Aging, Aging/physiology, Adolescent, Corpus callosum, Nerve Fibers, Myelinated, Human development, Corpus Callosum, 03 medical and health sciences, Nerve Fibers, Magnetic resonance imaging, 0302 clinical medicine, Neural Pathways, Humans, Preschool, Magnetic Resonance Imaging/methods, Child, Retrospective Studies, Corpus Callosum/growth & development, Cerebral Cortex, Sex Characteristics, Anthropometry, Anthropometry/methods, Neural Pathways/anatomy & histology, Cerebral Cortex/anatomy & histology, Magnetic Resonance Imaging, Neural Pathways/growth & development, 3. Good health, Cerebral Cortex/growth & development, Child, Preschool, Myelinated/physiology, Female |
| Περιγραφή: | Previous studies have shown that maturation of the white matter in terms of its relative signal intensity changes on MRI is almost complete at 2–3 years of age. We hypothesized that quantitative analysis may show maturation of the white matter during childhood and adolescence. In the present study we performed multi‐echo T2 relaxometry in 33 healthy subjects (girls, 15; boys, 18) aged 3–15 years. T2 relaxation times of the genu and splenium were measured. In healthy subjects, the T2 relaxation times were significantly correlated with age in both girls (r = 0.611, p = .016) and boys (r = 0.721, p = .001) in the splenium, but not in the genu (p > .05). To further confirm genu‐to‐splenium signal intensity ratio changes, a total of 389 brain MRIs were retrospectively selected from the patients who had normal results (189 girls/women, 200 boys/men; age range, 3–20 years). The genu‐to‐splenium signal intensity ratio was obtained from the T2‐weighted images. In patients with normal MRI, the genu‐to‐splenium signal intensity ratio was significantly decreased with age (p < .001) by 16 years. The T2 relaxation times gradually increase in the splenium during childhood and adolescence, suggestive of maturation. |
| Τύπος εγγράφου: | Article |
| Περιγραφή αρχείου: | 409~414 |
| Γλώσσα: | English |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2007.05.005 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/17964752 https://www.sciencedirect.com/science/article/pii/S0736574807000743 http://discovery.ucl.ac.uk/92331/ https://www.ncbi.nlm.nih.gov/pubmed/17964752 https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.ijdevneu.2007.05.005 https://onlinelibrary.wiley.com/doi/abs/10.1016/j.ijdevneu.2007.05.005 https://jhu.pure.elsevier.com/en/publications/visualization-of-maturation-of-the-corpus-callosum-during-childho-4 |
| Rights: | Wiley Online Library User Agreement CC BY NC ND |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....9df2559bb5e5cc3da41f652723aabeb0 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 1873474X 07365748 |
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| DOI: | 10.1016/j.ijdevneu.2007.05.005 |