Bibliographic Details
Title:
Whole-genome sequencing reveals host factors underlying critical COVID-19
Authors:
Kousathanas, Athanasios , Pairo-Castineira, Erola , Rawlik, Konrad , Stuckey, Alex , Odhams, Christopher A. , Walker, Susan , Russell, Clark D. , Malinauskas, Tomas , Wu, Yang , Millar, Jonathan , Shen, Xia , Elliott, Katherine S. , Griffiths, Fiona , Oosthuyzen, Wilna , Morrice, Kirstie , Keating, Sean , Wang, Bo , Rhodes, Daniel , Klaric, Lucija , Zechner, Marie , Parkinson, Nick , Siddiq, Afshan , Goddard, Peter , Donovan, Sally , Maslove, David , Nichol, Alistair , Semple, Malcolm G. , Zainy, Tala , Maleady-Crowe, Fiona , Todd, Linda , Salehi, Shahla , Knight, Julian , Elgar, Greg , Chan, Georgia , Arumugam, Prabhu , Patch, Christine , Rendon, Augusto , Bentley, David , Kingsley, Clare , Kosmicki, Jack A. , Horowitz, Julie E. , Baras, Aris , Abecasis, Goncalo R. , Ferreira, Manuel A. R. , Justice, Anne , Mirshahi, Tooraj , Oetjens, Matthew , Rader, Daniel J. , Ritchie, Marylyn D. , Verma, Anurag , Fowler, Tom A. , Shankar-Hari, Manu , Summers, Charlotte , Hinds, Charles , Horby, Peter , Ling, Lowell , McAuley, Danny , Montgomery, Hugh , Openshaw, Peter J. M. , Elliott, Paul , Walsh, Timothy , Tenesa, Albert , null, null , Baillie, J. Kenneth , Begg, Colin , Clohisey Hendry, Sara , Millar, Johnny , Pereira, Alexandre C. , Ponting, Chris P. , Rowan, Kathy , Aravindan, Latha , Armstrong, Ruth , Biggs, Heather , Boz, Ceilia , Brown, Adam , Clark, Richard , Coutts, Audrey , Coyle, Judy , Cullum, Louise , Das, Sukamal , Day, Nicky , Donnelly, Lorna , Duncan, Esther , Fawkes, Angie , Finernan, Paul , Fourman, Max Head , Furlong, Anita , Furniss, James , Gallagher, Bernadette , Gilchrist, Tammy , Golightly, Ailsa , Hafezi, Katarzyna , Hamilton, Debbie , Hendry, Ross , Law, Andy , Law, Dawn , Law, Rachel , Law, Sarah , Lidstone-Scott, Rebecca , Macgillivray, Louise , Maclean, Alan , Mal, Hanning , McCafferty, Sarah , Mcmaster, Ellie , Meikle, Jen , Moore, Shona C. , Murphy, Lee , Murphy, Sheena , Hellen, Mybaya , Zheng, Chenqing , Chen, Jiantao , Paterson, Trevor , Schon, Katherine , Stenhouse, Andrew , Das, Mihaela , Swets, Maaike , Szoor-McElhinney, Helen , Taneski, Filip , Turtle, Lance , Wackett, Tony , Ward, Mairi , Weaver, Jane , Wrobel, Nicola , Arbane, Gill , Bociek, Aneta , Campos, Sara , Grau, Neus , Jones, Tim Owen , Lim, Rosario , Marotti, Martina , Ostermann, Marlies , Whitton, Christopher , Alldis, Zoe , Astin-Chamberlain, Raine , Bibi, Fatima , Biddle, Jack , Blow, Sarah , Bolton, Matthew , Borra, Catherine , Bowles, Ruth , Burton, Maudrian , Choudhury, Yasmin , Collier, David , Cox, Amber , Easthope, Amy , Ebano, Patrizia , Fotiadis, Stavros , Gurasashvili, Jana , Halls, Rosslyn , Hartridge, Pippa , Kallon, Delordson , Kassam, Jamila , Lancoma-Malcolm, Ivone , Matharu, Maninderpal , May, Peter , Mitchelmore, Oliver , Newman, Tabitha , Patel, Mital , Pheby, Jane , Pinzuti, Irene , Prime, Zoe , Prysyazhna, Oleksandra , Shiel, Julian , Taylor, Melanie , Tierney, Carey , Wood, Suzanne , Zak, Anne , Zongo, Olivier , Bonner, Stephen , Hugill, Keith , Jones, Jessica , Liggett, Steven , Headlam, Evie , Bandla, Nageswar , Gellamucho, Minnie , Davies, Michelle , Thompson, Christopher , Abdelrazik, Marwa , Bakthavatsalam, Dhanalakshmi , Elhassan, Munzir , Ganesan, Arunkumar , Haldeos, Anne , Moreno-Cuesta, Jeronimo , Purohit, Dharam , Vincent, Rachel , Xavier, Kugan , Kumar, Rohit , Frater, Alasdair , Saleem, Malik , Carter, David , Jenkins, Samuel , Lamond, Zoe , Wall, Alanna , Fernandez-Roman, Jaime , Hamilton, David O. , Johnson, Emily , Johnston, Brian , Martinez, Maria Lopez , Mulla, Suleman , Shaw, David , Waite, Alicia A. C. , Waugh, Victoria , Welters, Ingeborg D. , Williams, Karen , Cavazza, Anna , Cockrell, Maeve , Corcoran, Eleanor , Depante, Maria , Finney, Clare , Jerome, Ellen , McPhail, Mark , Nayak, Monalisa , Noble, Harriet , O'Reilly, Kevin , Pappa, Evita , Saha, Rohit , Saha, Sian , Smith, John , Knighton, Abigail , Antcliffe, David , Banach, Dorota , Brett, Stephen , Coghlan, Phoebe , Fernandez, Ziortza , Gordon, Anthony , Rojo, Roceld , Arias, Sonia Sousa , Templeton, Maie , Meredith, Megan , Morris, Lucy , Ryan, Lucy , Clark, Amy , Sampson, Julia , Peters, Cecilia , Dent, Martin , Langley, Margaret , Ashraf, Saima , Wei, Shuying , Andrew, Angela , Bashyal, Archana , Davidson, Neil , Hutton, Paula , McKechnie, Stuart , Wilson, Jean , Baptista, David , Crowe, Rebecca , Fernandes, Rita , Herdman-Grant, Rosaleen , Joseph, Anna , O'Connor, Denise , Allen, Meryem , Loveridge, Adam , McKenley, India , Morino, Eriko , Naranjo, Andres , Simms, Richard , Sollesta, Kathryn , Swain, Andrew , Venkatesh, Harish , Khera, Jacyntha , Fox, Jonathan , Andrew, Gillian , Barclay, Lucy , Callaghan, Marie , Campbell, Rachael , Clark, Sarah , Hope, Dave , Marshall, Lucy , McCulloch, Corrienne , Briton, Kate , Singleton, Jo , Birch, Sophie , Brimfield, Lutece , Daly, Zoe , Pogson, David , Rose, Steve , Nown, Angela , Battle, Ceri , Brinkworth, Elaine , Harford, Rachel , Murphy, Carl , Newey, Luke , Rees, Tabitha , Williams, Marie , Arnold, Sophie , Polgarova, Petra , Stroud, Katerina , Meaney, Eoghan , Jones, Megan , Ng, Anthony , Agrawal, Shruti , Pathan, Nazima , White, Deborah , Daubney, Esther , Elston, Kay , Grauslyte, Lina , Hussain, Musarat , Phull, Mandeep , Pogreban, Tatiana , Rosaroso, Lace , Salciute, Erika , Franke, George , Wong, Joanna , George, Aparna , de Gordoa, Laura Ortiz-Ruiz , Peasgood, Emily , Phillips, Claire , Bates, Michelle , Dasgin, Jo , Gill, Jaspret , Nilsson, Annette , Scriven, James , Collins, Amy , Khaliq, Waqas , Gude, Estefania Treus , Delgado, Carlos Castro , Dawson, Deborah , Ding, Lijun , Durrant, Georgia , Ezeobu, Obiageri , Farnell-Ward, Sarah , Harrison, Abiola , Kanu, Rebecca , Leaver, Susannah , Maccacari, Elena , Manna, Soumendu , Saluzzio, Romina Pepermans , Queiroz, Joana , Samakomva, Tinashe , Sicat, Christine , Texeira, Joana , Da Gloria, Edna Fernandes , Lisboa, Ana , Rawlins, John , Mathew, Jisha , Kinch, Ashley , Hurt, William James , Shah, Nirav , Clark, Victoria , Thanasi, Maria , Yun, Nikki , Patel, Kamal , Bennett, Sara , Goodwin, Emma , Jackson, Matthew , Kent, Alissa , Tibke, Clare , Woodyatt, Wiesia , Zaki, Ahmed , Abraheem, Azmerelda , Bamford, Peter , Cawley, Kathryn , Dunmore, Charlie , Faulkner, Maria , Girach, Rumanah , Jeffrey, Helen , Jones, Rhianna , London, Emily , Nagra, Imrun , Nasir, Farah , Sainsbury, Hannah , Smedley, Clare , Patel, Tahera , Smith, Matthew , Chukkambotla, Srikanth , Kazi, Aayesha , Hartley, Janice , Dykes, Joseph , Hijazi, Muhammad , Keith, Sarah , Khan, Meherunnisa , Ryan-Smith, Janet , Springle, Philippa , Thomas, Jacqueline , Truman, Nick , Saad, Samuel , Coleman, Dabheoc , Fine, Christopher , Matt, Roseanna , Gay, Bethan , Dalziel, Jack , Ali, Syamlan , Goodchild, Drew , Harling, Rhiannan , Bhatterjee, Ravi , Goddard, Wendy , Davison, Chloe , Duberly, Stephen , Hargreaves, Jeanette , Bolton, Rachel , Davey, Miriam , Golden, David , Seaman, Rebecca , Cherian, Shiney , Cutler, Sean , Heron, Anne Emma , Roynon-Reed, Anna , Szakmany, Tamas , Williams, Gemma , Richards, Owen , Cheema, Yusuf , Brooke, Hollie , Buckley, Sarah , Suarez, Jose Cebrian , Charlesworth, Ruth , Hansson, Karen , Norris, John , Poole, Alice , Rose, Alastair , Sandhu, Rajdeep , Sloan, Brendan , Smithson, Elizabeth , Thirumaran, Muthu , Wagstaff, Veronica , Metcalfe, Alexandra , Brunton, Mark , Caterson, Jess , Coles, Holly , Frise, Matthew , Rai, Sabi Gurung , Jacques, Nicola , Keating, Liza , Tilney, Emma , Bartley, Shauna , Bhuie, Parminder , Gibson, Sian , Lyle, Amanda , McNeela, Fiona , Radhakrishnan, Jayachandran , Hughes, Alistair , Yates, Bryan , Reynolds, Jessica , Campbell, Helen , Thompsom, Maria , Dodds, Steve , Duffy, Stacey , Greer, Sandra , Shuker, Karen , Tridente, Ascanio , Khade, Reena , Sundar, Ashok , Tsinaslanidis, George , Birkinshaw, Isobel , Carter, Joseph , Howard, Kate , Ingham, Joanne , Joy, Rosie , Pearson, Harriet , Roche, Samantha , Scott, Zoe , Bancroft, Hollie , Bellamy, Mary , Carmody, Margaret , Daglish, Jacqueline , Moore, Faye , Rhodes, Joanne , Sangombe, Mirriam , Kadiri, Salma , Croft, Maria , White, Ian , Frost, Victoria , Aquino, Maia , Jha, Rajeev , Krishnamurthy, Vinodh , Lim, Lai , Lim, Li , Combes, Edward , Joefield, Teishel , Monnery, Sonja , Beech, Valerie , Trotman, Sallyanne , Almaden-Boyle, Christine , Austin, Pauline , Cabrelli, Louise , Cole, Stephen , Casey, Matt , Chapman, Susan , Whyte, Clare , Baird, Yolanda , Butler, Aaron , Chadbourn, Indra , Folkes, Linda , Fox, Heather , Gardner, Amy , Gomez, Raquel , Hobden, Gillian , Hodgson, Luke , King, Kirsten , Margarson, Michael , Martindale, Tim , Meadows, Emma , Raynard, Dana , Thirlwall, Yvette , Helm, David , Margalef, Jordi , Criste, Kristine , Cusack, Rebecca , Golder, Kim , Golding, Hannah , Jones, Oliver , Leggett, Samantha , Male, Michelle , Marani, Martyna , Prager, Kirsty , Williams, Toran , Roberts, Belinda , Salmon, Karen , Anderson, Peter , Archer, Katie , Austin, Karen , Davis, Caroline , Durie, Alison , Kelsall, Olivia , Thrush, Jessica , Vigurs, Charlie , Wild, Laura , Wood, Hannah-Louise , Tranter, Helen , Harrison, Alison , Cowley, Nicholas , McAlindon, Michael , Burtenshaw, Andrew , Digby, Stephen , Low, Emma , Morgan, Aled , Cother, Naiara , Rankin, Tobias , Clayton, Sarah , McCurdy, Alex , Ahmed, Cecilia , Baines, Balvinder , Clamp, Sarah , Colley, Julie , Haq, Risna , Hayes, Anne , Hulme, Jonathan , Hussain, Samia , Joseph, Sibet , Kumar, Rita , Maqsood, Zahira , Purewal, Manjit , Benham, Leonie , Bradshaw, Zena , Brown, Joanna , Caswell, Melanie , Cupitt, Jason , Melling, Sarah , Preston, Stephen , Slawson, Nicola , Stoddard, Emma , Warden, Scott , Deacon, Bethan , Lynch, Ceri , Pothecary, Carla , Roche, Lisa , Howe, Gwenllian Sera , Singh, Jayaprakash , Turner, Keri , Ellis, Hannah , Stroud, Natalie , Hunt, Jodie , Dearden, Joy , Dobson, Emma , Drummond, Andy , Mulcahy, Michelle , Munt, Sheila , O'Connor, Grainne , Philbin, Jennifer , Rishton, Chloe , Tully, Redmond , Winnard, Sarah , Cathcart, Susanne , Duffy, Katharine , Puxty, Alex , Puxty, Kathryn , Turner, Lynne , Ireland, Jane , Semple, Gary , Long, Kate , Whiteley, Simon , Wilby, Elizabeth , Ogg, Bethan , Cowton, Amanda , Kay, Andrea , Kent, Melanie , Potts, Kathryn , Wilkinson, Ami , Campbell, Suzanne , Brown, Ellen , Melville, Julie , Naisbitt, Jay , Joseph, Rosane , Lazo, Maria , Walton, Olivia , Neal, Alan , Alexander, Peter , Allen, Schvearn , Bradley-Potts, Joanne , Brantwood, Craig , Egan, Jasmine , Felton, Timothy , Padden, Grace , Ward, Luke , Moss, Stuart , Glasgow, Susannah , Abel, Lynn , Brett, Michael , Digby, Brian , Gemmell, Lisa , Hornsby, James , MacGoey, Patrick , O'Neil, Pauline , Price, Richard , Rodden, Natalie , Rooney, Kevin , Sundaram, Radha , Thomson, Nicola , Hopkins, Bridget , Thrasyvoulou, Laura , Willis, Heather , Clark, Martyn , Coulding, Martina , Jude, Edward , McCormick, Jacqueline , Mercer, Oliver , Potla, Darsh , Rehman, Hafiz , Savill, Heather , Turner, Victoria , Downes, Charlotte , Holding, Kathleen , Riches, Katie , Hilton, Mary , Hayman, Mel , Subramanian, Deepak , Daniel, Priya , Adanini, Oluronke , Bhatia, Nikhil , Msiska, Maines , Collins, Rebecca , Clement, Ian , Patel, Bijal , Gulati, A. , Hays, Carole , Webster, K. , Hudson, Anne , Webster, Andrea , Stephenson, Elaine , McCormack, Louise , Slater, Victoria , Nixon, Rachel , Hanson, Helen , Fearby, Maggie , Kelly, Sinead , Bridgett, Victoria , Robinson, Philip , Camsooksai, Julie , Humphrey, Charlotte , Jenkins, Sarah , Reschreiter, Henrik , Wadams, Beverley , Death, Yasmin , Bastion, Victoria , Clarke, Daphene , David, Beena , Kent, Harriet , Lorusso, Rachel , Lubimbi, Gamu , Murdoch, Sophie , Penacerrada, Melchizedek , Thomas, Alastair , Valentine, Jennifer , Vochin, Ana , Wulandari, Retno , Djeugam, Brice , Bell, Gillian , English, Katy , Katary, Amro , Wilcox, Louise , Bruce, Michelle , Connolly, Karen , Duncan, Tracy , Michael, Helen T. , Lindergard, Gabriella , Hey, Samuel , Fox, Claire , Alfonso, Jordan , Durrans, Laura Jayne , Guerin, Jacinta , Blackledge, Bethan , Harris, Jade , Hruska, Martin , Eltayeb, Ayaa , Lamb, Thomas , Hodgkiss, Tracey , Cooper, Lisa , Rothwell, Joanne , Allan, Angela , Anderson, Felicity , Kaye, Callum , Liew, Jade , Medhora, Jasmine , Scott, Teresa , Trumper, Erin , Botello, Adriana , Lankester, Liana , Nikitas, Nikitas , Wells, Colin , Stowe, Bethan , Spencer, Kayleigh , Brandwood, Craig , Smith, Lara , Birchall, Katie , Kolakaluri, Laurel , Baines, Deborah , Sukumaran, Anila , Apetri, Elena , Basikolo, Cathrine , Catlow, Laura , Charles, Bethan , Dark, Paul , Doonan, Reece , Harvey, Alice , Horner, Daniel , Knowles, Karen , Lee, Stephanie , Lomas, Diane , Lyons, Chloe , Marsden, Tracy , McLaughlan, Danielle , McMorrow, Liam , Pendlebury, Jessica , Perez, Jane , Poulaka, Maria , Proudfoot, Nicola , Slaughter, Melanie , Slevin, Kathryn , Thomas, Vicky , Walker, Danielle , Michael, Angiy , Collis, Matthew , Cosier, Tracey , Millen, Gemma , Richardson, Neil , Schumacher, Natasha , Weston, Heather , Rand, James , Baxter, Nicola , Henderson, Steven , Kennedy-Hay, Sophie , McParland, Christopher , Rooney, Laura , Sim, Malcolm , McCreath, Gordan , Akeroyd, Louise , Bano, Shereen , Bromley, Matt , Gurr, Lucy , Lawton, Tom , Morgan, James , Sellick, Kirsten , Warren, Deborah , Wilkinson, Brian , McGowan, Janet , Ledgard, Camilla , Stacey, Amelia , Pye, Kate , Bellwood, Ruth , Bentley, Michael , Bewley, Jeremy , Garland, Zoe , Grimmer, Lisa , Gumbrill, Bethany , Johnson, Rebekah , Sweet, Katie , Webster, Denise , Efford, Georgia , Convery, Karen , Fottrell-Gould, Deirdre , Hudig, Lisa , Keshet-Price, Jocelyn , Randell, Georgina , Stammers, Katie , Bokhari, Maria , Linnett, Vanessa , Lucas, Rachael , McCormick, Wendy , Ritzema, Jenny , Sanderson, Amanda , Wild, Helen , Rostron, Anthony , Roy, Alistair , Woods, Lindsey , Cornell, Sarah , Wakinshaw, Fiona , Rogerson, Kimberley , Jarmain, Jordan , Parker, Robert , Reddy, Amie , Turner-Bone, Ian , Wilding, Laura , Harding, Peter , Abernathy, Caroline , Foster, Louise , Gratrix, Andrew , Martinson, Vicky , Parkinson, Priyai , Stones, Elizabeth , Carbral-Ortega, Llucia , Bercades, Georgia , Brealey, David , Hass, Ingrid , MacCallum, Niall , Martir, Gladys , Raith, Eamon , Reyes, Anna , Smyth, Deborah , Zitter, Letizia , Benyon, Sarah , Marriott, Suzie , Park, Linda , Keenan, Samantha , Gordon, Elizabeth , Quinn, Helen , Baines, Kizzy , Cagova, Lenka , Fofano, Adama , Garner, Lucie , Holcombe, Helen , Mepham, Sue , Mitchell, Alice Michael , Mwaura, Lucy , Praman, Krithivasan , Vuylsteke, Alain , Zamikula, Julie , Purewal, Bally , Rivers, Vanessa , Bell, Stephanie , Blakemore, Hayley , Borislavova, Borislava , Faulkner, Beverley , Gendall, Emma , Goff, Elizabeth , Hayes, Kati , Thomas, Matt , Worner, Ruth , Smith, Kerry , Stephens, Deanna , Mew, Louise , Mwaura, Esther , Stewart, Richard , Williams, Felicity , Wren, Lynn , Sutherland, Sara-Beth , Bevan, Emily , Martin, Jane , Trodd, Dawn , Watson, Geoff , Wrey Brown, Caroline , Akinkugbe, Olugbenga , Bamford, Alasdair , Beech, Emily , Belfield, Holly , Bell, Michael , Davies, Charlene , Jones, Gareth A. L. , McHugh, Tara , Meghari, Hamza , O'Neill, Lauran , Peters, Mark J. , Ray, Samiran , Tomas, Ana Luisa , Burn, Iona , Hambrook, Geraldine , Manso, Katarina , Penn, Ruth , Shanmugasundaram, Pradeep , Tebbutt, Julie , Thornton, Danielle , Cole, Jade , Davies, Rhys , Duffin, Donna , Hill, Helen , Player, Ben , Thomas, Emma , Williams, Angharad , Griffin, Denise , Muchenje, Nycola , Mupudzi, Mcdonald , Partridge, Richard , Conyngham, Jo-Anna , Thomas, Rachel , Wright, Mary , Corral, Maria Alvarez , Jacob, Reni , Jones, Cathy , Denmade, Craig , Beavis, Sarah , Dale, Katie , Gascoyne, Rachel , Hawes, Joanne , Pritchard, Kelly , Stevenson, Lesley , Whileman, Amanda , Doble, Patricia , Hutter, Joanne , Pawley, Corinne , Shovelton, Charmaine , Vaida, Marius , Butcher, Deborah , O'Sullivan, Susie , Butterworth-Cowin, Nicola , Ahmad, Norfaizan , Barker, Joann , Bauchmuller, Kris , Bird, Sarah , Cawthron, Kay , Harrington, Kate , Jackson, Yvonne , Kibutu, Faith , Lenagh, Becky , Masuko, Shamiso , Mills, Gary H. , Raithatha, Ajay , Wiles, Matthew , Willson, Jayne , Newell, Helen , Lye, Alison , Nwafor, Lorenza , Jarman, Claire , Rowland-Jones, Sarah , Foote, David , Cole, Joby , Thompson, Roger , Watson, James , Hesseldon, Lisa , Macharia, Irene , Chetam, Luke , Smith, Jacqui , Ford, Amber , Anderson, Samantha , Birchall, Kathryn , Housley, Kay , Walker, Sara , Milner, Leanne , Hanratty, Helena , Trower, Helen , Phillips, Patrick , Oxspring, Simon , Donne, Ben , Jardine, Catherine , Williams, Dewi , Hay, Alasdair , Flanagan, Rebecca , Hughes, Gareth , Latham, Scott , McKenna, Emma , Anderson, Jennifer , Hull, Robert , Rhead, Kat , Cruz, Carina , Pattison, Natalie , Charnock, Rob , McFarland, Denise , Cosgrove, Denise , Ahmed, Ashar , Morris, Anna , Jakkula, Srinivas , Nune, Arvind , Ali, Asifa , Brady, Megan , Dale, Sam , Dance, Annalisa , Gledhill, Lisa , Greig, Jill , Hanson, Kathryn , Holdroyd, Kelly , Home, Marie , Kelly, Diane , Kitson, Ross , Matapure, Lear , Melia, Deborah , Mellor, Samantha , Nortcliffe, Tonicha , Pinnell, Jez , Robinson, Matthew , Shaw, Lisa , Shaw, Ryan , Thomis, Lesley , Wilson, Alison , Wood, Tracy , Bayo, Lee-Ann , Merwaha, Ekta , Ishaq, Tahira , Hanley, Sarah , Hibbert, Meg , Tetla, Dariusz , Woodford, Christopher , Durga, Latha , Kennard-Holden, Gareth , Branney, Debbie , Frankham, Jordan , Pitts, Sally , White, Nigel , Laha, Shondipon , Verlander, Mark , Williams, Alexandra , Altabaibeh, Abdelhakim , Alvaro, Ana , Gilbert, Kayleigh , Ma, Louise , Mostoles, Loreta , Parmar, Chetan , Simpson, Kathryn , Jetha, Champa , Booker, Lauren , Pratley, Anezka , Adams, Colene , Agasou, Anita , Arden, Tracie , Bowes, Amy , Boyle, Pauline , Beekes, Mandy , Button, Heather , Capps, Nigel , Carnahan, Mandy , Carter, Anne , Childs, Danielle , Donaldson, Denise , Hard, Kelly , Hurford, Fran , Hussain, Yasmin , Javaid, Ayesha , Jones, James , Jose, Sanal , Leigh, Michael , Martin, Terry , Millward, Helen , Motherwell, Nichola , Rikunenko, Rachel , Stickley, Jo , Summers, Julie , Ting, Louise , Tivenan, Helen , Tonks, Louise , Wilcox, Rebecca , Skinner, Denise , Gaylard, Jane , Mullan, Dee , Newman, Julie , Holland, Maureen , Keenan, Natalie , Lyons, Marc , Wassall, Helen , Marsh, Chris , Mahenthran, Mervin , Carter, Emma , Kong, Thomas , Blackman, Helen , Creagh-Brown, Ben , Donlon, Sinead , Michalak-Glinska, Natalia , Mtuwa, Sheila , Pristopan, Veronika , Salberg, Armorel , Smith, Eleanor , Stone, Sarah , Piercy, Charles , Verula, Jerik , Burda, Dorota , Montaser, Rugia , Harden, Lesley , Mayangao, Irving , Marriott, Cheryl , Bradley, Paul , Harris, Celia , Anderson, Susan , Andrews, Eleanor , Birch, Janine , Collins, Emma , Hammerton, Kate , O'Leary, Ryan , Clark, Michele , Purvis, Sarah , Barber, Russell , Hewitt, Claire , Hilldrith, Annette , Jackson-Lawrence, Karen , Shepardson, Sarah , Wills, Maryanne , Butler, Susan , Tavares, Silvia , Cunningham, Amy , Hindale, Julia , Arif, Sarwat , Bean, Sarah , Burt, Karen , Spivey, Michael , Demetriou, Carrie , Eckbad, Charlotte , Hierons, Sarah , Howie, Lucy , Mitchard, Sarah , Ramos, Lidia , Serrano-Ruiz, Alfredo , White, Katie , Kelly, Fiona , Cristiano, Daniele , Dormand, Natalie , Farzad, Zohreh , Gummadi, Mahitha , Liyanage, Kamal , Patel, Brijesh , Salmi, Sara , Sloane, Geraldine , Thwaites, Vicky , Varghese, Mathew , Zborowski, Anelise C. , Allan, John , Geary, Tim , Houston, Gordon , Meikle, Alistair , O'Brien, Peter , Forsey, Miranda , Kaliappan, Agilan , Nicholson, Anne , Riches, Joanne , Vertue, Mark , Allan, Elizabeth , Darlington, Kate , Davies, Ffyon , Easton, Jack , Kumar, Sumit , Lean, Richard , Menzies, Daniel , Pugh, Richard , Qiu, Xinyi , Davies, Llinos , Williams, Hannah , Scanlon, Jeremy , Davies, Gwyneth , Mackay, Callum , Lewis, Joanne , Rees, Stephanie , Oblak, Metod , Popescu, Monica , Thankachen, Mini , Higham, Andrew , Simpson, Kerry , Craig, Jayne , Baruah, Rosie , Morris, Sheila , Ferguson, Susie , Shepherd, Amy , Moore, Luke Stephen Prockter , Vizcaychipi, Marcela Paola , de Almeida Martins, Laura Gomes , Carungcong, Jaime , Ali, Inthakab Ali Mohamed , Beaumont, Karen , Blunt, Mark , Coton, Zoe , Curgenven, Hollie , Elsaadany, Mohamed , Fernandes, Kay , Mohamed Ally, Sameena , Rangarajan, Harini , Sarathy, Varun , Selvanayagam, Sivarupan , Vedage, Dave , White, Matthew , Gill, Mandy , Paul, Paul , Ratnam, Valli , Shelton, Sarah , Wynter, Inez , Carmody, Siobhain , Page, Valerie Joan , Beith, Claire Marie , Black, Karen , Clements, Suzanne , Morrison, Alan , Strachan, Dominic , Taylor, Margaret , Clarkson, Michelle , D'Sylva, Stuart , Norman, Kathryn , Auld, Fiona , Donnachie, Joanne , Edmond, Ian , Prentice, Lynn , Runciman, Nikole , Salutous, Dario , Symon, Lesley , Todd, Anne , Turner, Patricia , Short, Abigail , Sweeney, Laura , Murdoch, Euan , Senaratne, Dhaneesha , Hill, Michaela , Kannan, Thogulava , Crawley, Rikki , Crew, Abigail , Cunningham, Mishell , Daniels, Allison , Harrison, Laura , Hope, Susan , Inweregbu, Ken , Jones, Sian , Lancaster, Nicola , Matthews, Jamie , Nicholson, Alice , Wray, Gemma , Langton, Helen , Prout, Rachel , Watters, Malcolm , Novis, Catherine , Barron, Anthony , Collins, Ciara , Kaul, Sundeep , Passmore, Heather , Prendergast, Claire , Reed, Anna , Rogers, Paula , Shokkar, Rajvinder , Woodruff, Meriel , Middleton, Hayley , Polgar, Oliver , Nolan, Claire , Mahay, Kanta , Collier, Dawn , Hormis, Anil , Maynard, Victoria , Graham, Cheryl , Walker, Rachel , Knights, Ellen , Price, Alicia , Thomas, Alice , Thorpe, Chris , Behan, Teresa , Burnett, Caroline , Hatton, Jonathan , Heeney, Elaine , Mitra, Atideb , Newton, Maria , Pollard, Rachel , Stead, Rachael , Amin, Vishal , Anastasescu, Elena , Anumakonda, Vikram , Karthik, Komala , Kausar, Rizwana , Reid, Karen , Smith, Jacqueline , Imeson-Wood, Janet , Brown, Alison , Crickmore, Vikki , Debreceni, Gabor , Wilkins, Joy , Nicol, Liz , Reece-Anthony, Rosie , Birt, Mark , Ghosh, Alison , Williams, Emma , Allen, Louise , Beranova, Eva , Crisp, Nikki , Deery, Joanne , Hazelton, Tracy , Knight, Alicia , Price, Carly , Tilbey, Sorrell , Turki, Salah , Turney, Sharon , Cooper, Joshua , Finch, Cheryl , Liderth, Sarah , Quinn, Alison , Waddington, Natalia , Coventry, Tina , Fowler, Susan , MacMahon, Michael , McGregor, Amanda , Cowley, Anne , Highgate, Judith , Gregory, Jane , O'Connell, Susan , Smith, Tim , Barberis, Luigi , Gopal, Shameer , Harris, Nichola , Lake, Victoria , Metherell, Stella , Radford, Elizabeth , Daniel, Amelia , Finn, Joanne , Saha, Rajnish , White, Nikki , Donnison, Phil , Trim, Fiona , Eapen, Beena , Birch, Jenny , Bough, Laura , Goodsell, Josie , Tutton, Rebecca , Williams, Patricia , Williams, Sarah , Winter-Goodwin, Barbara , Nichol, Ailstair , Brickell, Kathy , Smyth, Michelle , Murphy, Lorna , Coetzee, Samantha , Gales, Alistair , Otahal, Igor , Raj, Meena , Sell, Craig , Hilltout, Paula , Evitts, Jayne , Tyler, Amanda , Waldron, Joanne , Beesley, Kate , Board, Sarah , Kubisz-Pudelko, Agnieszka , Lewis, Alison , Perry, Jess , Pippard, Lucy , Wood, Di , Buckley, Clare , Barry, Peter , Flint, Neil , Rekha, Patel , Hales, Dawn , Bunni, Lara , Jennings, Claire , Latif, Monica , Marshall, Rebecca , Subramanian, Gayathri , McGuigan, Peter J. , Wasson, Christopher , Finn, Stephanie , Green, Jackie , Collins, Erin , King, Bernadette , Campbell, Andy , Smuts, Sara , Duffield, Joseph , Smith, Oliver , Mallon, Lewis , Watkins, Claire , Botfield, Liam , Butler, Joanna , Dexter, Catherine , Fletcher, Jo , Garg, Atul , Kuravi, Aditya , Ranga, Poonam , Virgilio, Emma , Belagodu, Zakaula , Fuller, Bridget , Gherman, Anca , Olufuwa, Olumide , Paramsothy, Remi , Stuart, Carmel , Oakley, Naomi , Kamundi, Charlotte , Tyl, David , Collins, Katy , Silva, Pedro , Taylor, June , King, Laura , Coates, Charlotte , Crowley, Maria , Wakefield, Phillipa , Beadle, Jane , Johnson, Laura , Sargeant, Janet , Anderson, Madeleine , Brady, Ailbhe , Chan, Rebekah , Little, Jeff , McIvor, Shane , Prady, Helena , Whittle, Helen , Mathew, Bijoy , Attwood, Ben , Parsons, Penny , Ward, Geraldine , Bremmer, Pamela , Joe, West , Tracy, Baird , Jim, Ruddy , Davies, Ellie , Sathe, Sonia , Dennis, Catherine , McGregor, Alastair , Parris, Victoria , Srikaran, Sinduya , Sukha, Anisha , Clarke, Noreen , Whiteside, Jonathan , Mascarenhas, Mairi , Donaldson, Avril , Matheson, Joanna , Barrett, Fiona , O'Hara, Marianne , Okeefe, Laura , Bradley, Clare , Eastgate-Jackson, Christine , Filipe, Helder , Martin, Daniel , Maharajh, Amitaa , Garcia, Sara Mingo , Pakou, Glykeria , De Neef, Mark , Dent, Kathy , Horsley, Elizabeth , Akhtar, Muhammad Nauman , Pearson, Sandra , Potoczna, Dorota , Spencer, Sue , Clapham, Melanie , Harper, Rosemary , Poultney, Una , Rice, Polly , Mutch, Rachel , Armstrong, Lisa , Bates, Hayley , Dooks, Emma , Farquhar, Fiona , Hairsine, Brigid , McParland, Chantal , Packham, Sophie , Bi, Rehana , Scholefield, Barney , Ashton, Lydia , George, Linsha , Twiss, Sophie , Wright, David , Chablani, Manish , Kirkby, Amy , Netherton, Kimberley , Davies, Kim , O'Brien, Linda , Omar, Zohra , Perkins, Emma , Lewis, Tracy , Sutherland, Isobel , Burns, Karen , Chandler, Ben , Elliott, Kerry , Mallinson, Janine , Turnbull, Alison , Gondo, Prisca , Hadebe, Bernard , Kayani, Abdul , Masunda, Bridgett , Anderson, Taya , Hawcutt, Dan , O'Malley, Laura , Rad, Laura , Rogers, Naomi , Saunderson, Paula , Allison, Kathryn Sian , Afolabi, Deborah , Whitbread, Jennifer , Jones, Dawn , Dore, Rachael , Halkes, Matthew , Mercer, Pauline , Thornton, Lorraine , Dawson, Joy , Garrioch, Sweyn , Tolson, Melanie , Aldridge, Jonathan , Kapoor, Ritoo , Loader, David , Castle, Karen , Humphreys, Sally , Tampsett, Ruth , Mackintosh, Katherine , Ayers, Amanda , Harrison, Wendy , North, Julie , Allibone, Suzanne , Genetu, Roman , Kasipandian, Vidya , Patel, Amit , Mac, Ainhi , Murphy, Anthony , Mahjoob, Parisa , Nazari, Roonak , Worsley, Lucy , Fagan, Andrew , Bemand, Thomas , Black, Ethel , Dela Rosa, Arnold , Howle, Ryan , Jhanji, Shaman , Baikady, Ravishankar Rao , Tatham, Kate Colette , Thomas, Benjamin , Bell, Dina , Boyle, Rosalind , Douglas, Katie , Glass, Lynn , Lee, Emma , Lennon, Liz , Rattray, Austin , Taylor, Abigail , Hughes, Rachel Anne , Thomas, Helen , Rees, Alun , Duskova, Michaela , Phipps, Janet , Brooks, Suzanne , Edwards, Michelle , Quaid, Sheena , Watson, Ekaterina , Brayne, Adam , Fisher, Emma , Hunt, Jane , Jackson, Peter , Kaye, Duncan , Love, Nicholas , Parkin, Juliet , Tuckey, Victoria , van Koutrik, Lynne , Carter, Sasha , Andrew, Benedict , Findlay, Louise , Adams, Katie , Service, Jen , Williams, Alison , Cheyne, Claire , Saunderson, Anne , Moultrie, Sam , Odam, Miranda , Hall, Kathryn , Mapfunde, Isheunesu , Willis, Charlotte , Lyon, Alex , Sri-Chandana, Chunda , Scherewode, Joslan , Stephenson, Lorraine , Marsh, Sarah , Hardy, John , Houlden, Henry , Moncur, Eleanor , Tariq, Ambreen , Tucci, Arianna , Hobrok, Maria , Loosley, Ronda , McGuinness, Heather , Tench, Helen , Wolf-Roberts, Rebecca , Irvine, Val , Shelley, Benjamin , Gorman, Claire , Gupta, Abhinav , Timlick, Elizabeth , Brady, Rebecca , Milligan, Barry , Bellini, Arianna , Bryant, Jade , Mayer, Anton , Pickard, Amy , Roe, Nicholas , Sowter, Jason , Howlett, Alex , Fidler, Katy , Tagliavini, Emma , Donnelly, Kevin , Shelton, Janie F. , Shastri, Anjali J. , Ye, Chelsea , Weldon, Catherine H. , Filshtein-Sonmez, Teresa , Coker, Daniella , Symons, Antony , Esparza-Gordillo, Jorge , Aslibekyan, Stella , Auton, Adam , Pathak, Gita A. , Karjalainen, Juha , Stevens, Christine , Andrews, Shea J. , Kanai, Masahiro , Cordioli, Mattia , Polimanti, Renato , Pirinen, Matti , Harerimana, Nadia , Veerapen, Kumar , Wolford, Brooke , Nguyen, Huy , Solomonson, Matthew , Liao, Rachel G. , Chwialkowska, Karolina , Trankiem, Amy , Balaconis, Mary K. , Hayward, Caroline , Richmond, Anne , Campbell, Archie , Morris, Marcela , Fawns-Ritchie, Chloe , Glessner, Joseph T. , Shaw, Douglas M. , Chang, Xiao , Polikowski, Hannah , Petty, Lauren E. , Chen, Hung-Hsin , Wanying, Zhu , Hakonarson, Hakon , Porteous, David J. , Below, Jennifer , North, Kari , McCormick, Joseph B. , Timmers, Paul R. H. J. , Wilson, James F. , D'Mellow, Kenton , Kerr, Shona M. , Niemi, Mari E. K. , Nkambul, Lindokuhle , von Hohenstaufen, Kathrin Aprile , Sobh, Ali , Eltoukhy, Madonna M. , Yassen, Amr M. , Hegazy, Mohamed A. F. , Okasha, Kamal , Eid, Mohammed A. , Moahmed, Hanteera S. , Shahin, Doaa , El-Sherbiny, Yasser M. , Elhadidy, Tamer A. , Abd Elghafar, Mohamed S. , El-Jawhari, Jehan J. , Mohamed, Attia A. S. , Elnagdy, Marwa H. , Samir, Amr , Abdel-Aziz, Mahmoud , Khafaga, Walid T. , El-Lawaty, Walaa M. , Torky, Mohamed S. , El-shanshory, Mohamed R. , Batini, Chiara , Lee, Paul H. , Shrine, Nick , Williams, Alexander T. , Tobin, Martin D. , Guyatt, Anna L. , John, Catherine , Packer, Richard J. , Ali, Altaf , Free, Robert C. , Wang, Xueyang , Wain, Louise V. , Hollox, Edward J. , Venn, Laura D. , Bee, Catherine E. , Adams, Emma L. , Niavarani, Ahmadreza , Sharififard, Bahareh , Aliannejad, Rasoul , Amirsavadkouhi, Ali , Naderpour, Zeinab , Tadi, Hengameh Ansari , Aleagha, Afshar Etemadi , Ahmadi, Saeideh , Moghaddam, Seyed Behrooz Mohseni , Adamsara, Alireza , Saeedi, Morteza , Abdollahi, Hamed , Hosseini, Abdolmajid , Chariyavilaskul, Pajaree , Chamnanphon, Monpat , Suttichet, Thitima B. , Shotelersuk, Vorasuk , Pongpanich, Monnat , Phokaew, Chureerat , Chetruengchai, Wanna , Jantarabenjakul, Watsamon , Putchareon, Opass , Torvorapanit, Pattama , Puthanakit, Thanyawee , Suchartlikitwong, Pintip , Hirankarn, Nattiya , Nilaratanakul, Voraphoj , Sodsai, Pimpayao , Brumpton, Ben M. , Hveem, Kristian , Willer, Cristen , Zhou, Wei , Rogne, Tormod , Solligard, Erik , Åsvold, Bjørn Olav , Abedalthagafi, Malak , Alaamery, Manal , Alqahtani, Saleh , Barakeh, Duna , Al Harthi, Fawz , Alsolm, Ebtehal , Safieh, Leen Abu , Alowayn, Albandary M. , Alqubaishi, Fatimah , Al Mutairi, Amal , Mangul, Serghei , Alshareef, Abdulraheem , Sawaji, Mona , Almutairi, Mansour , Aljawini, Nora , Albesher, Nour , Arabi, Yaseen M. , Mahmoud, Ebrahim S. , Khattab, Amin K. , Halawani, Roaa T. , Alahmadey, Ziab Z. , Albakri, Jehad K. , Felemban, Walaa A. , Suliman, Bandar A. , Hasanato, Rana , Al-Awdah, Laila , Alghamdi, Jahad , AlZahrani, Deema , AlJohani, Sameera , Al-Afghani, Hani , Alrashed, May , AlDhawi, Nouf , AlBardis, Hadeel , Alkwai, Sarah , Alswailm, Moneera , Almalki, Faisal , Albeladi, Maha , Almohammed, Iman , Barhoush, Eman , Albader, Anoud , Massadeh, Salam , AlMalik, Abdulaziz , Alotaibi, Sara , Alghamdi, Bader , Jung, Junghyun , Fawzy, Mohammad S. , Lee, Yunsung , Magnus, Per , Trogstad, Lill-Iren S. , Helgeland, Øyvind , Harris, Jennifer R. , Mangino, Massimo , Spector, Tim D. , Duncan, Emma , Smieszek, Sandra P. , Przychodzen, Bartlomiej P. , Polymeropoulos, Christos , Polymeropoulos, Vasilios , Polymeropoulos, Mihael H. , Fernandez-Cadenas, Israel , Perez-Tur, Jordi , Llucià-Carol, Laia , Cullell, Natalia , Muiño, Elena , Cárcel-Márquez, Jara , DeDiego, Marta L. , Iglesias, Lara Lloret , Planas, Anna M. , Soriano, Alex , Rico, Veronica , Agüero, Daiana , Bedini, Josep L. , Lozano, Francisco , Domingo, Carlos , Robles, Veronica , Ruiz-Jaén, Francisca , Márquez, Leonardo , Gomez, Juan , Coto, Eliecer , Albaiceta, Guillermo M. , García-Clemente, Marta , Dalmau, David , Arranz, Maria J. , Dietl, Beatriz , Serra-Llovich, Alex , Soler, Pere , Colobrán, Roger , Martín-Nalda, Andrea , Martínez, Alba Parra , Bernardo, David , Rojo, Silvia , Fiz-López, Aida , Arribas, Elisa , de la Cal-Sabater, Paloma , Segura, Tomás , González-Villa, Esther , Serrano-Heras, Gemma , Martí-Fàbregas, Joan , Jiménez-Xarrié, Elena , de Felipe Mimbrera, Alicia , Masjuan, Jaime , García-Madrona, Sebastian , Domínguez-Mayoral, Anna , Villalonga, Joan Montaner , Menéndez-Valladares, Paloma , Chasman, Daniel I. , Buring, Julie E. , Ridker, Paul M. , Franco, Giulianini , Sesso, Howard D. , Manson, JoAnn E. , Glessner, Joseph R. , Medina-Gomez, Carolina , Uitterlinden, Andre G. , Ikram, M. Arfan , Kristiansson, Kati , Koskelainen, Sami , Perola, Markus , Donner, Kati , Kivinen, Katja , Palotie, Aarno , Ripatti, Samuli , Ruotsalainen, Sanni , Kaunisto, Mari , Nakanishi, Tomoko , Butler-Laporte, Guillaume , Forgetta, Vincenzo , Morrison, David R. , Ghosh, Biswarup , Laurent, Laetitia , Belisle, Alexandre , Henry, Danielle , Abdullah, Tala , Adeleye, Olumide , Mamlouk, Noor , Kimchi, Nofar , Afrasiabi, Zaman , Rezk, Nardin , Vulesevic, Branka , Bouab, Meriem , Guzman, Charlotte , Petitjean, Louis , Tselios, Chris , Xue, Xiaoqing , Schurr, Erwin , Afilalo, Jonathan , Afilalo, Marc , Oliveira, Maureen , Brenner, Bluma , Lepage, Pierre , Ragoussis, Jiannis , Auld, Daniel , Brassard, Nathalie , Durand, Madeleine , Chassé, Michaël , Kaufmann, Daniel E. , Lathrop, G. Mark , Mooser, Vincent , Richards, J. Brent , Li, Rui , Adra, Darin , Rahmouni, Souad , Georges, Michel , Moutschen, Michel , Misset, Benoit , Darcis, Gilles , Guiot, Julien , Guntz, Julien , Azarzar, Samira , Gofflot, Stéphanie , Beguin, Yves , Claassen, Sabine , Malaise, Olivier , Huynen, Pascale , Meuris, Christelle , Thys, Marie , Jacques, Jessica , Léonard, Philippe , Frippiat, Frederic , Giot, Jean-Baptiste , Sauvage, Anne-Sophie , von Frenckell, Christian , Belhaj, Yasmine , Lambermont, Bernard , Pigazzini, Sara , Nkambule, Lindokuhle , Daya, Michelle , Shortt, Jonathan , Rafaels, Nicholas , Wicks, Stephen J. , Crooks, Kristy , Barnes, Kathleen C. , Gignoux, Christopher R. , Chavan, Sameer , Laisk, Triin , Läll, Kristi , Lepamets, Maarja , Mägi, Reedik , Esko, Tõnu , Reimann, Ene , Milani, Lili , Alavere, Helene , Metsalu, Kristjan , Puusepp, Mairo , Metspalu, Andres , Naaber, Paul , Laane, Edward , Pesukova, Jaana , Peterson, Pärt , Kisand, Kai , Tabri, Jekaterina , Allos, Raili , Hensen, Kati , Starkopf, Joel , Ringmets, Inge , Tamm, Anu , Kallaste, Anne , Bochud, Pierre-Yves , Rivolta, Carlo , Bibert, Stéphanie , Quinodoz, Mathieu , Kamdar, Dhryata , Boillat, Noémie , Nussle, Semira Gonseth , Albrich, Werner , Suh, Noémie , Neofytos, Dionysios , Erard, Véronique , Voide, Cathy , de Cid, Rafael , Galván-Femenía, Iván , Blay, Natalia , Carreras, Anna , Cortés, Beatriz , Farré, Xavier , Sumoy, Lauro , Moreno, Victor , Mercader, Josep Maria , Guindo-Martinez, Marta , Torrents, David , Kogevinas, Manolis , Garcia-Aymerich, Judith , Castaño-Vinyals, Gemma , Dobaño, Carlota , Renieri, Alessandra , Mari, Francesca , Fallerini, Chiara , Daga, Sergio , Benetti, Elisa , Baldassarri, Margherita , Fava, Francesca , Frullanti, Elisa , Valentino, Floriana , Doddato, Gabriella , Giliberti, Annarita , Tita, Rossella , Amitrano, Sara , Bruttini, Mirella , Croci, Susanna , Meloni, Ilaria , Mencarelli, Maria Antonietta , Rizzo, Caterina Lo , Pinto, Anna Maria , Beligni, Giada , Tommasi, Andrea , Di Sarno, Laura , Palmieri, Maria , Carriero, Miriam Lucia , Alaverdian, Diana , Busani, Stefano , Bruno, Raffaele , Vecchia, Marco , Belli, Mary Ann , Picchiotti, Nicola , Sanarico, Maurizio , Gori, Marco , Furini, Simone , Mantovani, Stefania , Ludovisi, Serena , Mondelli, Mario Umberto , Castelli, Francesco , Quiros-Roldan, Eugenia , Antoni, Melania Degli , Zanella, Isabella , Vaghi, Massimo , Rusconi, Stefano , Siano, Matteo , Montagnani, Francesca , Emiliozzi, Arianna , Fabbiani, Massimiliano , Rossetti, Barbara , Bargagli, Elena , Bergantini, Laura , D'Alessandro, Miriana , Cameli, Paolo , Bennett, David , Anedda, Federico , Marcantonio, Simona , Scolletta, Sabino , Franchi, Federico , Mazzei, Maria Antonietta , Guerrini, Susanna , Conticini, Edoardo , Cantarini, Luca , Frediani, Bruno , Tacconi, Danilo , Spertilli, Chiara , Feri, Marco , Donati, Alice , Scala, Raffaele , Guidelli, Luca , Spargi, Genni , Corridi, Marta , Nencioni, Cesira , Croci, Leonardo , Bandini, Maria , Caldarelli, Gian Piero , Piacentini, Paolo , Desanctis, Elena , Cappelli, Silvia , Canaccini, Anna , Verzuri, Agnese , Anemoli, Valentina , Ognibene, Agostino , Pancrazzi, Alessandro , Lorubbio, Maria , D'Arminio Monforte, Antonella , Miraglia, Federica Gaia , Girardis, Massimo , Venturelli, Sophie , Cossarizza, Andrea , Antinori, Andrea , Vergori, Alessandra , Gabrieli, Arianna , Riva, Agostino , Francisci, Daniela , Schiaroli, Elisabetta , Paciosi, Francesco , Scotton, Pier Giorgio , Andretta, Francesca , Panese, Sandro , Scaggiante, Renzo , Gatti, Francesca , Parisi, Saverio Giuseppe , Baratti, Stefano , Della Monica, Matteo , Piscopo, Carmelo , Capasso, Mario , Russo, Roberta , Andolfo, Immacolata , Iolascon, Achille , Fiorentino, Giuseppe , Carella, Massimo , Castori, Marco , Merla, Giuseppe , Squeo, Gabriella Maria , Aucella, Filippo , Raggi, Pamela , Marciano, Carmen , Perna, Rita , Bassetti, Matteo , Di Biagio, Antonio , Sanguinetti, Maurizio , Masucci, Luca , Valente, Serafina , Mandalà, Marco , Giorli, Alessia , Salerni, Lorenzo , Zucchi, Patrizia , Parravicini, Pierpaolo , Menatti, Elisabetta , Trotta, Tullio , Giannattasio, Ferdinando , Coiro, Gabriella , Lena, Fabio , Coviello, Domenico A. , Mussini, Cristina , Martinelli, Enrico , Mancarella, Sandro , Tavecchia, Luisa , Crotti, Lia , Gabbi, Chiara , Rizzi, Marco , Maggiolo, Franco , Ripamonti, Diego , Bachetti, Tiziana , La Rovere, Maria Teresa , Sarzi-Braga, Simona , Bussotti, Maurizio , Ceri, Stefano , Pinoli, Pietro , Raimondi, Francesco , Biscarini, Filippo , Stella, Alessandra , Zguro, Kristina , Capitani, Katia , Suardi, Claudia , Dei, Simona , Parati, Gianfranco , Ravaglia, Sabrina , Artuso, Rosangela , Bottà, Giordano , Di Domenico, Paolo , Rancan, Ilaria , Perrella, Antonio , Bianchi, Francesco , Romani, Davide , Bergomi, Paola , Catena, Emanuele , Colombo, Riccardo , Tanfoni, Marco , Vincenti, Antonella , Ferri, Claudio , Grassi, Davide , Pessina, Gloria , Tumbarello, Mario , Di Pietro, Massimo , Sabrina, Ravaglia , Luchi, Sauro , Barbieri, Chiara , Acquilini, Donatella , Andreucci, Elena , Segala, Francesco Vladimiro , Tiseo, Giusy , Falcone, Marco , Lista, Mirjam , Poscente, Monica , De Vivo, Oreste , Petrocelli, Paola , Guarnaccia, Alessandra , Baroni, Silvia , Smith, Albert V. , Boughton, Andrew P. , Li, Kevin W. , LeFaive, Jonathon , Annis, Aubrey , Justice, Anne E. , Chittoor, Geetha , Josyula, Navya Shilpa , Leader, Joseph B. , Carey, Dave J. , Gass, Matthew C. , Cantor, Michael N. , Yadav, Ashish , van Heel, David A. , Hunt, Karen A. , Mason, Dan , Huang, Qin Qin , Finer, Sarah , Trivedi, Bhavi , Griffiths, Christopher J. , Martin, Hilary C. , Wright, John , Trembath, Richard C. , Soranzo, Nicole , Zhao, Jing Hua , Butterworth, Adam S. , Danesh, John , Di Angelantonio, Emanuele , Franke, Lude , Boezen, Marike , Deelen, Patrick , Claringbould, Annique , Lopera, Esteban , Warmerdam, Robert , Vonk, Judith M. , van Blokland, Irene , Lanting, Pauline , Ori, Anil P. S. , Zöllner, Sebastian , Wang, Jiongming , Beck, Andrew , Peloso, Gina , Ho, Yuk-Lam , Sun, Yan V. , Huffman, Jennifer E. , O'Donnell, Christopher J. , Cho, Kelly , Tsao, Phil , Gaziano, J. Michael , Nivard, Michel , de Geus, Eco , Bartels, Meike , Jan Hottenga, Jouke , Weiss, Scott T. , Karlson, Elizabeth W. , Smoller, Jordan W. , Green, Robert C. , Feng, Yen-Chen Anne , Mercader, Josep , Murphy, Shawn N. , Meigs, James B. , Woolley, Ann E. , Perez, Emma F. , Rader, Daniel , Li, Binglan , Verma, Shefali S. , Lucas, Anastasia , Bradford, Yuki , Zeberg, Hugo , Frithiof, Robert , Hultström, Michael , Lipcsey, Miklos , Nkambul, Lindo , Tardif, Nicolas , Rooyackers, Olav , Grip, Jonathan , Maricic, Tomislav , Karczewski, Konrad J. , Atkinson, Elizabeth G. , Tsuo, Kristin , Baya, Nikolas , Turley, Patrick , Gupta, Rahul , Callier, Shawneequa , Walters, Raymond K. , Palmer, Duncan S. , Sarma, Gopal , Cheng, Nathan , Lu, Wenhan , Bryant, Sam , Churchhouse, Claire , Cusick, Caroline , Goldstein, Jacqueline I. , King, Daniel , Seed, Cotton , Finucane, Hilary , Martin, Alicia R. , Satterstrom, F. Kyle , Wilson, Daniel J. , Armstrong, Jacob , Rudkin, Justine K. , Band, Gavin , Earle, Sarah G. , Lin, Shang-Kuan , Arning, Nicolas , Crook, Derrick W. , Wyllie, David H. , O'Connell, Anne Marie , Spencer, Chris C. A. , Koelling, Nils , Caulfield, Mark J. , Scott, Richard H. , Fowler, Tom , Moutsianas, Loukas , Pasko, Dorota , Ball, Catherine A. , Hong, Eurie L. , Rand, Kristin , Girshick, Ahna , Guturu, Harendra , Baltzell, Asher Haug , Roberts, Genevieve , Park, Danny , Coignet, Marie , McCurdy, Shannon , Knight, Spencer , Partha, Raghavendran , Rhead, Brooke , Zhang, Miao , Berkowitz, Nathan , Gaddis, Michael , Noto, Keith , Ruiz, Luong , Pavlovic, Milos , Sloofman, Laura G. , Charney, Alexander W. , Beckmann, Noam D. , Schadt, Eric E. , Jordan, Daniel M. , Thompson, Ryan C. , Gettler, Kyle , Abul-Husn, Noura S. , Ascolillo, Steven , Buxbaum, Joseph D. , Chaudhary, Kumardeep , Cho, Judy H. , Itan, Yuval , Kenny, Eimear E. , Belbin, Gillian M. , Sealfon, Stuart C. , Sebra, Robert P. , Salib, Irene , Collins, Brett L. , Levy, Tess , Britvan, Bari , Keller, Katherine , Tang, Lara , Peruggia, Michael , Hiester, Liam L. , Niblo, Kristi , Aksentijevich, Alexandra , Labkowsky, Alexander , Karp, Avrohom , Zlatopolsky, Menachem , Preuss, Michael , Loos, Ruth J. F. , Nadkarni, Girish N. , Do, Ron , Hoggart, Clive , Choi, Sam , Underwood, Slayton J. , O'Reilly, Paul , Huckins, Laura M. , Zyndorf, Marissa , Daly, Mark J. , Neale, Benjamin M. , Ganna, Andrea , Vitart, Veronique , Yang, Jian , Bretherick, Andrew D. , Hendry, Sara Clohisey
Contributors:
Department of Health & Social Care (UK), Medical Research Council (UK), Roslin Institute, Pérez-Tur, Jordi [0000-0002-9111-1712], Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72 ], National Institute for Health Research, UKRI MRC COVID-19 Rapid Response Call, UK Research and Innovation, investigators, GenOMICC, investigators, 23andMe, Initiative, COVID-19 Human Genetics, Rahmouni, Souad, DARCIS, Gilles, LAMBERMONT, Bernard, DSpace at Cambridge pro (8.1), University of Aberdeen.Aberdeen Centre for Evaluation, Kousathanas, Athanasio, Pairo-Castineira, Erola, Rawlik, Konrad, Stuckey, Alex, Odhams, Christopher A, Walker, Susan, Russell, Clark D, Malinauskas, Toma, Wu, Yang, Millar, Jonathan, Shen, Xia, Elliott, Katherine S, Griffiths, Fiona, Oosthuyzen, Wilna, Morrice, Kirstie, Keating, Sean, Wang, Bo, Rhodes, Daniel, Klaric, Lucija, Zechner, Marie, Parkinson, Nick, Siddiq, Afshan, Goddard, Peter, Donovan, Sally, Maslove, David, Nichol, Alistair, Semple, Malcolm G, Zainy, Tala, Maleady-Crowe, Fiona, Todd, Linda, Salehi, Shahla, Knight, Julian, Elgar, Greg, Chan, Georgia, Arumugam, Prabhu, Patch, Christine, Rendon, Augusto, Bentley, David, Kingsley, Clare, Kosmicki, Jack A, Horowitz, Julie E, Baras, Ari, Abecasis, Goncalo R, Ferreira, Manuel A R, Justice, Anne, Mirshahi, Tooraj, Oetjens, Matthew, Rader, Daniel J, Ritchie, Marylyn D, Verma, Anurag, Fowler, Tom A, Shankar-Hari, Manu, Summers, Charlotte, Hinds, Charle, Horby, Peter, Ling, Lowell, Mcauley, Danny, Montgomery, Hugh, Openshaw, Peter J M, Elliott, Paul, Walsh, Timothy, Tenesa, Albert, Genomicc, Investigator, Renieri, A., Mari, F., Fallerini, C., Daga, S., Benetti, E., Baldassarri, M., Fava, F., Frullanti, E., Valentino, F., Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Mencarelli, Ma., Lo Rizzo, C., Pinto, Am., Beligni, G., Di Sarno, L., Palmieri, M., Carriero, M. L., Alaverdian, D., Picchiotti, N., Gori, M., Montagnani, F., Fabbiani, M., Rossetti, B., Bargagli, E., Bergantini, L., D’Alessandro, M., Cameli, P., Bennett, D., Anedda, F., Marcantonio, S., Scolletta, S.
Source:
Naturehttps://doi.org/10.1038/s41586-022-04576-6 https://doi.org/10.1038/s41586-022-04576-6 https://doi.org/10.1038/s41586-022-04576-6
Publisher Information:
Springer Science and Business Media LLC, 2022.
Publication Year:
2022
Subject Terms:
FUT2 gene , genetic association , Supplementary Data , Genetics & genetic processes , BCL11A gene , intensive care unit , PATHWAY , Génétique & processus génétiques , transcriptomics , Fucosyltransferase , genetics , Phospholipid Transfer Proteins , membrane , pathophysiology , virus replication , whole genome sequencing , 0303 health sciences , Human/genetics , C-Type , covid genetics , ASSOCIATION , 16. Peace & justice , cohort analysis , Fucosyltransferases , GenOMICC Investigators , Life sciences , GenOMICC investigators , COVID-19/genetics , Host-Pathogen Interactions/genetics , 3. Good health , Cell Surface , PC_20004 , Science & Technology - Other Topics , Infectious diseases , MC_PC_19025 , disease severity , interferon signaling , CD209 gene , E-Selectin , MC_PC_1905 , Human , mutational analysis , Respiratory distress syndrome , ATP-Binding Cassette Transporter , Critical Illness , factor analysis , ICAM5 gene , Receptors, Cell Surface , 23andMe investigators , Article , 03 medical and health sciences , critically ill patient , SDG 3 - Good Health and Well-being , 204979/Z/16/Z , critical illness , Humans , human , procedures , genome , Blood Coagulation , 23andMe , BBS/E/D/30002275 , Science & Technology , Factor VIII , BBS/E/D/10002070 , SARS-CoV-2/pathogenicity , UK Research and Innovation (UKRI) , mucin 1 , major clinical study , SIGNAL , Critical Illness/mortality , Cell Adhesion Molecule , Nerve Tissue Protein , genetic variation , Biotechnology and Biological Sciences Research Council (BBSRC) , ATP-Binding Cassette Transporters , cell adhesion molecule , transcriptome , Cell Adhesion Molecules , 0301 basic medicine , Galactoside 2-alpha-L-fucosyltransferase , Genome-wide association studies , Covid-19 Human Genetics Initiative , 223164/Z/21/Z , name=General , Lectins , Receptors , genetic variability , Genetics research , TOOL , Wellcome Trust , intensive care , Multidisciplinary , Genome , disseminated intravascular clotting , Critical Care , Genome-Wide Association Study , Interleukin-10 Receptor beta Subunit , Lectins, C-Type , Mucin-1 , Nerve Tissue Proteins , Repressor Proteins , SARS-CoV-2 , COVID-19 , Genome, Human , Host-Pathogen Interactions , Whole Genome Sequencing , PLSCR1 gene , Host-Pathogen Interaction , Multidisciplinary Sciences , female , blood clotting factor 8 , Genome-Wi , Sciences du vivant , Critical Illne , leukocyte , SELE gene , General Science & Technology , ATP11A gene , IL10RB gene , Mendelian randomization analysis , MUC1 gene , QH426 Genetics , R Medicine , DENDRITIC CELLS , blood clotting , Phospholipid Transfer Protein , CD209 antigen , coronavirus disease 2019 , antigen , disease prevalence , male , LINKAGE , pneumonia , controlled study , General , gene , QH426 , National Institute for Health Research (NIHR) , MRNO2995X , genome-wide association study , BBS/E/D/20002172 , Repressor Protein , Medical Research Council (MRC) , ONTOLOGY , COVID-19 Human Genetics Initiative , cell differentiation , Genome, Human/genetics , gene expression , MC_PC_20029 , genetic predisposition , bone marrow cell
Description:
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
Document Type:
Article
File Description:
application/pdf; application/zip; text/xml; 97 - +; text; STAMPA
Language:
English
ISSN:
1476-4687
DOI:
10.1038/s41586-022-04576-6
DOI:
10.17863/cam.81812
DOI:
10.17863/cam.86318
DOI:
10.13039/501100000265
DOI:
10.13039/501100000276
Access URL:
https://www.nature.com/articles/s41586-022-04576-6_reference.pdf https://pubmed.ncbi.nlm.nih.gov/35255492 https://ddd.uab.cat/record/284470 https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15353 http://hdl.handle.net/10261/288775 http://livrepository.liverpool.ac.uk/3151780/1/manuscript.pdf https://irep.ntu.ac.uk/id/eprint/46862/1/1584825_El-Sherbiny.pdf https://research.manchester.ac.uk/en/publications/6da4642f-f5f8-499a-b196-72d4f3e7b9f8 https://doi.org/10.1038/s41586-022-04576-6 https://hdl.handle.net/11588/986156 https://pure.eur.nl/en/publications/8906f68a-7516-459d-a48b-c59515928759 https://doi.org/10.1038/s41586-022-04576-6 https://research.rug.nl/en/publications/f7cfd8bf-ac8d-4fc2-9d97-e776c12fc305 https://doi.org/10.1038/s41586-022-04576-6 https://hdl.handle.net/11370/f7cfd8bf-ac8d-4fc2-9d97-e776c12fc305 http://hdl.handle.net/10044/1/96351 https://ddd.uab.cat/record/284470 https://hdl.handle.net/10807/231799 https://doi.org/10.1038/s41586-022-04576-6 https://pure.qub.ac.uk/en/publications/9ae8c785-b143-4390-8c3a-12346481e7b7 https://hdl.handle.net/20.500.11820/8b1d3897-21b1-4dd3-bd26-f7291559786d https://www.pure.ed.ac.uk/ws/files/256453474/s41586_022_04576_6_reference.pdf https://hdl.handle.net/11567/1112675 https://doi.org/10.1038/s41586-022-04576-6 https://hdl.handle.net/11697/189172 https://doi.org/10.1038/s41586-022-04576-6 https://discovery-pp.ucl.ac.uk/id/eprint/10146723 /http://bura.brunel.ac.uk/handle/2438/26025
Rights:
CC BYhttp://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 / (http://creativecommons.org/licenses/by/4.0 /) .
Accession Number:
edsair.doi.dedup.....935b3ec637928030f77e4b5a0147df18
Database:
OpenAIRE