Academic Journal
Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum
| Title: | Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum |
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| Authors: | Indrit Bègue, Janis Brakowski, Erich Seifritz, Alain Dagher, Philippe N. Tobler, Matthias Kirschner, Stefan Kaiser |
| Contributors: | University of Zurich, Bègue, Indrit |
| Source: | Schizophrenia Research. 246:85-94 |
| Publisher Information: | Elsevier BV, 2022. |
| Publication Year: | 2022 |
| Subject Terms: | cerebellum, Apathy, apathy, functional neuroimaging, psychosis spectrum, Biological psychiatry, 2738 Psychiatry and Mental Health, Psychosis spectrum, Cerebellum / diagnostic imaging, 03 medical and health sciences, Cognition, 0302 clinical medicine, 10007 Department of Economics, Mesencephalon, Cerebellum, Humans, Functional neuroimaging, Psychotic Disorders / diagnostic imaging, Magnetic Resonance Imaging, 330 Economics, 3. Good health, psychiatry and mental health, Psychotic Disorders, 616.89, 2803 Biological Psychiatry, Apathy / physiology |
| Description: | Negative symptoms in the psychosis continuum are linked to impairments in reward processing and cognitive function. Processes at the interface of reward processing and cognition and their relation to negative symptoms remain little studied, despite evidence suggestive of integration in mechanisms and neural circuitry. Here, we investigated brain activation during reward-dependent modulation of working memory (WM) and their relationship to negative symptoms in subclinical and early stages of the psychosis continuum. We included 27 persons with high schizotypal personality traits and 23 patients with first episode psychosis as well as 27 healthy controls. Participants underwent functional magnetic resonance imaging while performing an established 2-back WM task with two reward levels (5 CHF vs. no reward), which allowed us to assess common reward-cognition regions through whole-brain conjunction analyses and to investigate relations with clinical scores of negative symptoms. As expected for behavior, reward facilitated performance while cognitive load diminished it. At the neural level, the conjunction of high reward and high cognitive load contrasts across the psychosis continuum showed increased hemodynamic activity in the thalamus and the cerebellar vermis. During high cognitive load, more severe apathy but not diminished expression in the psychosis continuum was associated with reduced activity in right lateral orbitofrontal cortex, midbrain, posterior vermal cerebellum, caudate and lateral parietal cortex. Our results suggest that hypoactivity in the cerebellar vermis and the cortical-striatal-midbrain-circuitry in the psychosis continuum relates to apathy possibly via impaired flexible cognitive resource allocation for effective goal pursuit. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; 1_s2.0_S0920996422002444_main.pdf - application/pdf |
| Language: | English |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2022.06.010 |
| DOI: | 10.1101/2022.02.09.479617 |
| DOI: | 10.5167/uzh-219957 |
| Access URL: | https://www.biorxiv.org/content/biorxiv/early/2022/02/10/2022.02.09.479617.full.pdf https://pubmed.ncbi.nlm.nih.gov/35728420 https://archive-ouverte.unige.ch/unige:166144 https://doi.org/10.1016/j.schres.2022.06.010 https://www.zora.uzh.ch/id/eprint/219957/ https://doi.org/10.5167/uzh-219957 |
| Rights: | CC BY CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....8abdb30d41b0628d3bd48f7fd4992423 |
| Database: | OpenAIRE |
| ISSN: | 09209964 |
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| DOI: | 10.1016/j.schres.2022.06.010 |