Academic Journal
Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients
| Title: | Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients |
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| Authors: | BIOLO, GIANNI, STULLE M., BIANCO F., MENGOZZI G., BARAZZONI, ROCCO, VASILE A., PANZETTA G., GUARNIERI, GIANFRANCO |
| Contributors: | Biolo, Gianni, Stulle, M., Bianco, F., Mengozzi, G., Barazzoni, Rocco, Vasile, A., Panzetta, G., Guarnieri, Gianfranco |
| Source: | Nephrology Dialysis Transplantation. 23:991-997 |
| Publisher Information: | Oxford University Press (OUP), 2007. |
| Publication Year: | 2007 |
| Subject Terms: | Insulin action, Male, 0301 basic medicine, 0303 health sciences, L-carnitine supplementation, glucose metabolism, Proteins, protein metabolism, haemodialysis patients, Middle Aged, 3. Good health, 03 medical and health sciences, Glucose, Double-Blind Method, Leucine, Renal Dialysis, Carnitine, Injections, Intravenous, Humans, Insulin, Kidney Failure, Chronic, Female, Insulin Resistance, Aged |
| Description: | Impaired protein anabolism and insulin resistance are characteristic features of maintenance haemodialysis patients. We have used a randomised, matched-paired, double-blind, placebo-controlled experimental design to determine the capability of intravenous L-carnitine supplementation to modify insulin resistance and protein catabolism in non-diabetic patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis treatment.L-carnitine (20 mg x kg(-1)) (n = 9) or placebo (n = 10) were given intravenously at the end of seven consecutive dialysis sessions. Whole-body protein and glucose metabolism were assessed on interdialytic days by the L[1-(13)C]leucine and the [2,2-(2)H(2)]glucose kinetic models in the postabsorptive state and during euglicemic hyperinsulinemic clamp studies at baseline and at the end of the treatment period.L-carnitine supplementation was associated with lower (P < 0.05) rates of leucine oxidation (-11 +/- 12%) and appearance from proteolysis (-6 +/- 2%) during the clamp studies than after placebo supplementation. The rates of glucose appearance in the postabsorptive state did not change significantly in the patients receiving L-carnitine treatment. Insulin-mediated glucose disappearance was improved by L-carnitine only in those patients (n = 5) (+18 +/- 3%, P < 0.05 vs placebo group, n = 5) with greater baseline insulin resistance, selected according to the median value of insulin sensitivity before treatment.L-carnitine supplementation was associated with protein-sparing effects in maintenance haemodialysis patients during hyperinsulinemia. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfm664 |
| Access URL: | https://academic.oup.com/ndt/article-pdf/23/3/991/7626361/gfm664.pdf https://pubmed.ncbi.nlm.nih.gov/18045815 http://hdl.handle.net/11368/1844959 https://academic.oup.com/ndt/article/23/3/991/1830011 https://paperity.org/p/41555325/insulin-action-on-glucose-and-protein-metabolism-during-l-carnitine-supplementation-in https://www.ncbi.nlm.nih.gov/pubmed/18045815 https://hdl.handle.net/11368/1844959 |
| Accession Number: | edsair.doi.dedup.....8a2f5b7405d8414f1ed68d63c4daead1 |
| Database: | OpenAIRE |
| ISSN: | 14602385 09310509 |
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| DOI: | 10.1093/ndt/gfm664 |