Academic Journal
FGF-23 and sFRP-4 in Chronic Kidney Disease and Post-Renal Transplantation
| Τίτλος: | FGF-23 and sFRP-4 in Chronic Kidney Disease and Post-Renal Transplantation |
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| Συγγραφείς: | Karen Wiesen, Alex J. Brown, John Vassiliadis, Susan C. Schiavi, Sangeeta Pande, Cynthia S. Ritter, Eduardo Slatapolsky, Marcos Rothstein, Rajesh Kumar |
| Πηγή: | Nephron Physiology. 104:p23-p32 |
| Στοιχεία εκδότη: | S. Karger AG, 2006. |
| Έτος έκδοσης: | 2006 |
| Θεματικοί όροι: | Male, Hypophosphatemia, Kidney Transplantation, Phosphates, 3. Good health, Fibroblast Growth Factors, Fibroblast Growth Factor-23, 03 medical and health sciences, Kidney Tubules, Postoperative Complications, 0302 clinical medicine, Parathyroid Hormone, Proto-Oncogene Proteins, Humans, Kidney Failure, Chronic, Female |
| Περιγραφή: | Background: The phosphatonins fibroblast growth factor-23 (FGF-23) and FRP-4 are inhibitors of tubular phosphate reabsorption that may play a role in the hyperphosphatemia associated with chronic kidney disease (CKD) or in the hypophosphatemia associated with renal transplants. Methods: Plasma FGF-23, FRP-4, phosphorus and parathyroid hormone were measured in patients at all stages of CKD. Phosphate regulation of FGF-23 and secreted frizzled related protein-4 (sFRP-4) was examined in end-stage renal disease patients in the presence and absence of therapeutic phosphate binder usage. In renal transplant patients, plasma FGF-23, sFRP-4 and phosphorus concentrations were determined before and 4–5 days after transplantation. Results: Plasma FGF-23 correlated with creatinine clearance (r2 = –0.584, p < 0.0001) and plasma phosphorus (r2 = 0.347, p < 0.001) in CKD patients and with plasma phosphorus (r2 = 0.448, p < 0.001) in end-stage renal disease patients. Phosphate binder withdrawal increased FGF-23 levels. In kidney transplant patients, dramatic decreases in FGF-23 (–88.8 ± 5.4%) and phosphorus (–64 ± 10.2%) were observed by 4–5 days post-transplantation. In patients with post-transplant hypophosphatemia, FGF-23 levels correlated inversely with plasma phosphorus (r2 = 0.661, p < 0.05). sFRP-4 levels did not change with creatinine clearance or hyperphosphatemia in CKD or end-stage renal disease patients, and no relation was noted between post-transplant sFRP-4 levels and hypophosphatemia. Conclusions: In CKD, FGF-23 levels rose with decreasing creatinine clearance rates and increasing plasma phosphorus levels, and rapidly decreased post-transplantation suggesting FGF-23 is cleared by the kidney. Residual FGF-23 may contribute to the hypophosphatemia in post-transplant patients. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1660-2137 |
| DOI: | 10.1159/000093277 |
| Σύνδεσμος πρόσβασης: | https://europepmc.org/articles/pmc4446726?pdf=render https://pubmed.ncbi.nlm.nih.gov/16691036 https://mayoclinic.pure.elsevier.com/en/publications/fgf-23-and-sfrp-4-in-chronic-kidney-disease-and-post-renal-transp https://pubmed.ncbi.nlm.nih.gov/16691036/ http://europepmc.org/articles/PMC4446726 https://www.ncbi.nlm.nih.gov/pubmed/16691036 |
| Rights: | URL: https://www.karger.com/Services/SiteLicenses |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....824dd0d285bc52b82c25483a7c4e6c83 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 16602137 |
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| DOI: | 10.1159/000093277 |