Academic Journal
Advanced MR diffusion characterization of neural tissue using directional diffusion kurtosis analysis
| Title: | Advanced MR diffusion characterization of neural tissue using directional diffusion kurtosis analysis |
|---|---|
| Authors: | Wu, EX, Qi, L, Cheung, MM, Hui, ES |
| Source: | 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. :3941-3944 |
| Publisher Information: | IEEE, 2008. |
| Publication Year: | 2008 |
| Subject Terms: | Imaging, Three-Dimensional - methods, Models, Statistical, Phantoms, Imaging, Normal Distribution, Brain, Water, Image Interpretation, Computer-Assisted - methods, Rats, Diffusion, Brain - anatomy and histology - metabolism - pathology, 03 medical and health sciences, Diffusion Magnetic Resonance Imaging, Imaging, Three-Dimensional, 0302 clinical medicine, Water - metabolism, Body Water, Formaldehyde, Image Interpretation, Computer-Assisted, Animals, Humans |
| Description: | MR Diffusion kurtosis imaging (DKI) was proposed recently to study the deviation of water diffusion from Gaussian distribution. Mean kurtosis (MK), directionally averaged kurtosis, has been shown to be useful in assessing pathophysilogical changes. However, MK is not sensitive to kurtosis change occurring along a specific direction. Therefore, orthogonal transformation of the 4th order kurtosis tensor was introduced in the current study to compute kurtoses along the 3 eigenvector directions of the 2nd order diffusion tensor. Such axial (K( parallel)) and radial (K perpendicular) kurtoses measured the kurtoses along the directions parallel and perpendicular, respectively, to the principal diffusion direction. DKI experiments were performed in normal adult and formalin-fixed rat brain, and developmental brains. The results showed that directional kurtosis analysis revealed different information for tissue characterization. |
| Document Type: | Article Conference object |
| DOI: | 10.1109/iembs.2008.4650072 |
| Access URL: | http://www.polyu.edu.hk/ama/staff/new/qilq/hcqw1.pdf https://pubmed.ncbi.nlm.nih.gov/19163575 https://ieeexplore.ieee.org/document/4650072/ http://www.ncbi.nlm.nih.gov/pubmed/19163575 https://www.polyu.edu.hk/ama/staff/new/qilq/hcqw1.pdf https://europepmc.org/abstract/MED/19163575 https://hub.hku.hk/handle/10722/61986 https://pubmed.ncbi.nlm.nih.gov/19163575/ http://hdl.handle.net/10722/61986 |
| Accession Number: | edsair.doi.dedup.....7e6e4cbf093568ad6b58dbe67a881bbd |
| Database: | OpenAIRE |
| DOI: | 10.1109/iembs.2008.4650072 |
|---|