Academic Journal
Association between biological age, clinical and biochemical indicators, manifestation of cognitive disorders and health indicators in patients with arterial hypertension
| Τίτλος: | Association between biological age, clinical and biochemical indicators, manifestation of cognitive disorders and health indicators in patients with arterial hypertension |
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| Συγγραφείς: | Kolesnikova, O. V., Zaprovalna, O. E., Radchenko, A. O., Potapenko, A. V. |
| Πηγή: | Украинский терапевтический журнал; № 4 (2020); 5-15 Український терапевтичний журнал; № 4 (2020); 5-15 Ukrainian Therapeutical Journal; № 4 (2020); 5-15 |
| Στοιχεία εκδότη: | Publishing Company VIT-A-POL, 2020. |
| Έτος έκδοσης: | 2020 |
| Θεματικοί όροι: | arterial hypertension, low cardiovascular risk, biological age, assessment of cognitive dysfunction, health indicators, артериальная гипертензия, низкий кардиоваскулярный риск, биологический возраст, оценка когнитивных нарушений, показатели здоровья, артеріальна гіпертензія, низький кардіоваскулярний ризик, біологічний вік, оцінка когнітивних порушень, показники здоров'я, 3. Good health |
| Περιγραφή: | The aim of this work was to determine the association between biological age (BA), clinical and biochemical parameters, cognitive functions and subjective health assessment in patients with arterial hypertension (AH) and low-grade cardiovascular risk (CVR).Materials and methods. The examinations involved 95 patients (50 men and 45 women) with the mean age of 43.8 years — from 25 to 59.8 years. All patients were divided into 2 groups: control group consisted of patients without hypertension (n = 24) and the second (main) group included patients with grade 1 — 2 stages 1 — 2 AH with low and moderate CVR (n = 71). Each group was dived into two subgroups:: 25 — 44 years old and 45 — 60 years old patients. Clinical, biochemical and anthropometric parameters were determined in patients. BA of patients was determined using the method named after A. G. Gorelkin and B. B. Pinkhasov, cognitive dysfunction was assessed based on the results of the questionnaires, namely Montreal Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSS), and health status was estimated using European Quality of Life Questionnaire (EQ-5D).Results. Significant differences were found between patients of the main and control groups in terms of BA (p = 0.000), weight (p = 0.016), body mass index (BMI) (p = 0.02), waist circumference (WC) (p = 0.001) and thigh circumference (p = 0.013). Analysis of the parameter values distribution in patients aged from 25 to 45 years old with and without AH showed significant differences in BA (p = 0.025), weight (p = 0.009), BMI (p = 0.048), WC (p = 0.007), levels of triglyceride (TG) (p = 0.025), very low density lipoprotein cholesterol (VLDL-C) (p = 0.025), high-density lipoprotein cholesterol (HDL-C) (p = 0.000), atherogenic coefficient (AC) (p = 0.001), creatinine (p = 0.007) and MoCA results (p = 0.000). Patients in the main group aged 45 to 60 years had significant differences in the levels of total cholesterol (p = 0.002), TG (p = 0.015), VLDL-C (p = 0.042), AC (p = 0.010), and low-density lipoprotein cholesterol (LDL-C) (p = 0.042), increased alanine aminotransferase (p = 0.021), DSS (p = 0.000) compared with controls. Decrease in cognitive functions in patients with AH in comparison with controls (p |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| ISSN: | 2522-1175 1605-7295 |
| DOI: | 10.30978/utj2020-4-5 |
| Σύνδεσμος πρόσβασης: | http://utj.com.ua/article/view/221972 |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....7d6b088a3a253d64a3e4cb16e7c63820 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 25221175 16057295 |
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| DOI: | 10.30978/utj2020-4-5 |