Academic Journal
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
| Τίτλος: | Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment |
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| Συγγραφείς: | CAPURON L, PAGNONI, Giuseppe, DEMETRASHVILI M, WOOLWINE BJ, NEMEROFF CB, BERNS GS, MILLER AH |
| Πηγή: | Biological Psychiatry. 58:190-196 |
| Στοιχεία εκδότη: | Elsevier BV, 2005. |
| Έτος έκδοσης: | 2005 |
| Θεματικοί όροι: | Adult, Male, Brain Mapping, Interferon-alpha, Middle Aged, Neuropsychological Tests, Antiviral Agents, Gyrus Cinguli, Hepatitis C, Magnetic Resonance Imaging, 3. Good health, Oxygen, 03 medical and health sciences, 0302 clinical medicine, Space Perception, Ribavirin, immunity, brain, fmri, cognitive, psychomotor slowing, interferon, psychoneuroimmunology, neuroimaging, anterior cingulate, Reaction Time, Humans, Attention, Female, Photic Stimulation |
| Περιγραφή: | There has been increasing interest in the role of immunologic processes, notably cytokines, in the development of behavioral alterations, especially in medically ill patients. Interferon (IFN)-alpha is notorious for causing behavioral symptoms, including depression, fatigue, and cognitive dysfunction, and has been used to investigate the effects of cytokines on the brain.In the present study we assessed the effects of low-dose IFN-alpha on brain activity, using functional magnetic resonance imaging during a task of visuospatial attention in patients infected with hepatitis C virus (HCV).Despite endorsing symptoms of impaired concentration and fatigue, IFN-alpha-treated patients (n = 10) exhibited task performance and activation of parietal and occipital brain regions similar to that seen in HCV-infected control subjects (n = 11). Interestingly, however, in contrast to control subjects, IFN-alpha-treated patients exhibited significant activation in the dorsal part of the anterior cingulate cortex (ACC), which highly correlated with the number of task-related errors. No such correlation was found in control subjects.Consistent with the role of the ACC in conflict monitoring, ACC activation during IFN-alpha administration suggests that cytokines might increase processing conflict or reduce the threshold for conflict detection, thereby signaling the need to exert greater mental effort to maintain performance. Such alterations in ACC activity might in turn contribute to cytokine-induced behavioral changes. |
| Τύπος εγγράφου: | Article |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2005.03.033 |
| Σύνδεσμος πρόσβασης: | https://europepmc.org/articles/pmc1366492?pdf=render https://pubmed.ncbi.nlm.nih.gov/16084839 https://core.ac.uk/display/53978063 http://www.ccnl.emory.edu/greg/ACC%20Interferon%20Biol%20Psych.pdf https://open.library.emory.edu/publications/emory:ts423/ https://miami.pure.elsevier.com/en/publications/anterior-cingulate-activation-and-error-processing-during-interfe https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366492/ https://iris.unimore.it/handle/11380/609284 https://hdl.handle.net/11380/609284 https://doi.org/10.1016/j.biopsych.2005.03.033 |
| Rights: | Elsevier TDM |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....705c167cd0e70118df0768e504dd20ce |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 00063223 |
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| DOI: | 10.1016/j.biopsych.2005.03.033 |