Academic Journal
Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy
| Title: | Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy |
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| Authors: | Maartje Klaver, Daan van Velzen, Christel de Blok, Nienke Nota, Chantal Wiepjes, Justine Defreyne, Thomas Schreiner, Alessandra Fisher, Jos Twisk, Jaap Seidell, Guy T’Sjoen, Martin den Heijer, Renée de Mutsert |
| Source: | J Clin Endocrinol Metab Klaver, M, van Velzen, D, de Blok, C, Nota, N, Wiepjes, C, Defreyne, J, Schreiner, T, Fisher, A, Twisk, J, Seidell, J, t'Sjoen, G, den Heijer, M & de Mutsert, R 2022, 'Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy', The Journal of clinical endocrinology and metabolism, vol. 107, no. 1, pp. e153-e164. https://doi.org/10.1210/clinem/dgab616 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM |
| Publisher Information: | The Endocrine Society, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Adult, Male, Hormone Replacement Therapy, visceral fat, Hormone Replacement Therapy/adverse effects, Obesity/physiopathology, Intra-Abdominal Fat, Transgender Persons, Body Mass Index, lipids, Young Adult, Transgender Persons/statistics & numerical data, SDG 3 - Good Health and Well-being, Risk Factors, insulin resistance, Medicine and Health Sciences, Humans, Obesity, Prospective Studies, Cardiovascular Diseases/etiology, Online Only Articles, Adiposity, hormone therapy, Cardiometabolic Risk Factors, Prognosis, transgender, 3. Good health, Cardiovascular Diseases, Female, Intra-Abdominal Fat/physiopathology, Insulin Resistance, Follow-Up Studies |
| Description: | Introduction Excess visceral fat increases the risk of type 2 diabetes and cardiovascular disease and is influenced by sex hormones. Our aim was to investigate changes in visceral fat and the ratio of visceral fat to total body fat (VAT/TBF) and their associations with changes in lipids and insulin resistance after 1 year of hormone therapy in trans persons. Methods In 179 trans women and 162 trans men, changes in total body and visceral fat estimated with dual-energy X-ray absorptiometry before and after 1 year of hormone therapy were related to lipids and insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR)] with linear regression analysis. Results In trans women, total body fat increased by 4.0 kg (95% CI 3.4, 4.7), while the amount of visceral fat did not change (−2 grams; 95% CI −15, 11), albeit with a large range from −318 to 281, resulting in a decrease in the VAT/TBF ratio of 17% (95% CI 15, 19). In trans men, total body fat decreased with 2.8 kg (95% CI 2.2, 3.5), while the amount of visceral fat did not change (3 g; 95% CI −10, 16; range −372, 311), increasing the VAT/TBF ratio by 14% (95% CI 10, 17). In both groups, VAT/TBF was not associated with changes in blood lipids or HOMA-IR. Conclusions Hormone therapy in trans women and trans men resulted in changes in VAT/TBF, mainly due to changes in total body fat and were unrelated to changes in cardiometabolic risk factors, which suggests that any unfavorable cardiometabolic effects of hormone therapy are not mediated by changes in visceral fat or VAT/TBF. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab616 |
| Access URL: | https://academic.oup.com/jcem/article-pdf/107/1/e153/41819420/dgab616.pdf https://pubmed.ncbi.nlm.nih.gov/34415999 https://hdl.handle.net/1871.1/f3d8f3f6-00b7-4995-a16e-01ff9d471f70 https://research.vu.nl/en/publications/f3d8f3f6-00b7-4995-a16e-01ff9d471f70 https://doi.org/10.1210/clinem/dgab616 https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgab616/40348538/dgab616.pdf https://www.ncbi.nlm.nih.gov/pubmed/34415999 https://pubmed.ncbi.nlm.nih.gov/34415999/ https://research.vumc.nl/en/publications/9e1cf853-2152-4ad2-a2b0-b1be39f14fe4 https://hdl.handle.net/1887/3572060 https://pure.amsterdamumc.nl/en/publications/6ca9fb7f-6a6b-41af-9781-845f690c65fc https://doi.org/10.1210/clinem/dgab616 http://doi.org/10.1210/clinem/dgab616 https://biblio.ugent.be/publication/01GT1XNV9VTXRW06Z47D4MT9Q6/file/01GT1XPMGCC8CHZY8MXTMG3SZC http://hdl.handle.net/1854/LU-01GT1XNV9VTXRW06Z47D4MT9Q6 https://biblio.ugent.be/publication/01GT1XNV9VTXRW06Z47D4MT9Q6 |
| Rights: | CC BY NC ND CC BY |
| Accession Number: | edsair.doi.dedup.....6fde1ef24b3f92bb6592bb0080227dbe |
| Database: | OpenAIRE |
| ISSN: | 19457197 0021972X |
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| DOI: | 10.1210/clinem/dgab616 |