Academic Journal
PRO-INFLAMMATORY PHENOTYPE OF PERIVASCULAR ASTROCYTES AND CD133+ ENDOTHELIAL PROGENITOR CELLS IN MURINE MODEL OF ALZHEIMER’S DISEASE
| Τίτλος: | PRO-INFLAMMATORY PHENOTYPE OF PERIVASCULAR ASTROCYTES AND CD133+ ENDOTHELIAL PROGENITOR CELLS IN MURINE MODEL OF ALZHEIMER’S DISEASE |
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| Συγγραφείς: | Yuliya K. Komleva, Olga L. Lopatina, Anatoliy I. Chernykh, Yana V. Gorina, A. B. Salmina, Svetlana I. Paschenko |
| Πηγή: | Фундаментальная и клиническая медицина, Vol 3, Iss 1, Pp 6-15 (2018) |
| Στοιχεία εκδότη: | Kemerovo State Medical University, 2018. |
| Έτος έκδοσης: | 2018 |
| Θεματικοί όροι: | 0301 basic medicine, Medicine (General), 0303 health sciences, 03 medical and health sciences, R5-920, perivascular astrocytes, периваскулярная астроглия, инфламмасомы nlrp3, alzheimer's disease, nlrp3 inflammasomes, моделирование болезни альцгеймера у мышей, клетки-предшественники эндотелиоцитов, endothelial progenitor cells |
| Περιγραφή: | Aim. To study the expression of NLRP3 in perivascular astrocytes and CD133+ endothelial progenitor cells in mice with amyloid-induced neurodegeneration.Materials and Methods. Ten days following intrahippocampal injection of Aβ1-42, male CD1 mice (4 months, weight 25-30 g) were sacrificed with the further immunohistochemical examination of the NLRP3 expression in S100 beta + and CD133+ cells using confocal microscopy. Results. We detected an increased number of S100beta + cells upon the administration of β-amyloid to the hippocampus. Moreover, a strong colocalization of S100beta and NLRP3 in the dentate gyrus of both groups was revealed indicative of neuroinflammation. CD133 immunostaining did not identify any differences in CD133+ cells between mice with Alzheimer’s disease and sham-treated mice, yet there was a notable reduction in CD133+ cell count after intrahippocampal injection of β-amyloid. Conclusion. Neuroinflammation induced by β-amyloid is associated with the formation of NL-RP3 inflammasomes and decreased neovascularization capacity. |
| Τύπος εγγράφου: | Article Other literature type |
| ISSN: | 2500-0764 |
| DOI: | 10.23946/2500-0764-2018-3-1-6-15 |
| Σύνδεσμος πρόσβασης: | https://doaj.org/article/3218c5435efb41149bf6b30126a2826b |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....6ee5ef1ece3f6e6a6918c1bc6b8b2f27 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 25000764 |
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| DOI: | 10.23946/2500-0764-2018-3-1-6-15 |