Academic Journal
Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum
| Τίτλος: | Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum |
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| Συγγραφείς: | Tine Pooters, Ilse Gantois, Ben Vermaercke, Rudi D’Hooge |
| Συνεισφορές: | Neurology |
| Πηγή: | Behavioural Brain Research. 298:134-141 |
| Στοιχεία εκδότη: | Elsevier BV, 2016. |
| Έτος έκδοσης: | 2016 |
| Θεματικοί όροι: | Exploratory Behavior/physiology, Spatial Memory/physiology, 0301 basic medicine, Memory Disorders, Learning Disabilities, Motor Activity/physiology, Motor Activity, Neuropsychological Tests, Spatial Navigation/physiology, Memory Disorders/physiopathology, Mice, Inbred C57BL, Neostriatum, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Maze Learning/physiology, Rotarod Performance Test, Neostriatum/physiopathology, Exploratory Behavior, Animals, Female, Maze Learning, Learning Disorders/physiopathology, Spatial Memory, Spatial Navigation |
| Περιγραφή: | Dorsal striatum has been shown to contribute to spatial learning and memory, but the role of striatal subregions in this important aspect of cognitive functioning remains unclear. Moreover, the spatial-cognitive mechanisms that underlie the involvement of these regions in spatial navigation have scarcely been studied. We therefore compared spatial learning and memory performance in mice with lesions in dorsomedial (DMS) and dorsolateral striatum (DLS) using the hidden-platform version of the Morris water maze (MWM) task. Compared to sham-operated controls, animals with DMS damage were impaired during MWM acquisition training. These mice displayed delayed spatial learning, increased thigmotaxis, and increased search distance to the platform, in the absence of major motor dysfunction, working memory defects or changes in anxiety or exploration. They failed to show a preference for the target quadrant during probe trials, which further indicates that spatial reference memory was impaired in these animals. Search strategy analysis moreover demonstrated that DMS-lesioned mice were unable to deploy cognitively advanced spatial search strategies. Conversely, MWM performance was barely affected in animals with lesions in DLS. In conclusion, our results indicate that DMS and DLS display differential functional involvement in spatial learning and memory. Our results show that DMS, but not DLS, is crucial for the ability of mice to acquire spatial information and their subsequent deployment of spatial search strategies. These data clearly identify DMS as a crucial brain structure for spatial learning and memory, which could explain the occurrence of neurocognitive impairments in brain disorders that affect the dorsal striatum. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2015.11.001 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/26548360 https://www.ncbi.nlm.nih.gov/pubmed/26548360 http://www.sciencedirect.com/science/article/pii/S0166432815302722 https://www.research.ed.ac.uk/portal/en/publications/inability-to-acquire-spatial-information-and-deploy-spatial-search-strategies-in-mice-with-lesions-in-dorsomedial-striatum(985873d8-28a5-4043-b5e9-732248b54569)/export.html http://www.research.ed.ac.uk/portal/en/publications/inability-to-acquire-spatial-information-and-deploy-spatial-search-strategies-in-mice-with-lesions-in-dorsomedial-striatum(985873d8-28a5-4043-b5e9-732248b54569)/export.html https://pubmed.ncbi.nlm.nih.gov/26548360/ https://core.ac.uk/display/34645800 https://biblio.vub.ac.be/vubir/inability-to-acquire-spatial-information-and-deploy-spatial-search-strategies-in-mice-with-lesions-in-dorsomedial-striatum(ea965720-7901-4e9e-90f3-9c4db384a9e4).html https://hdl.handle.net/20.500.14017/ea965720-7901-4e9e-90f3-9c4db384a9e4 https://doi.org/10.1016/j.bbr.2015.11.001 |
| Rights: | Elsevier TDM |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....6c1cdfe329bf8c094931068e56ff92eb |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 01664328 |
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| DOI: | 10.1016/j.bbr.2015.11.001 |