Academic Journal
Incidence of brain injuries in a large cohort of very preterm and extremely preterm infants at term-equivalent age: results of a single tertiary neonatal care center over 10 years
| Τίτλος: | Incidence of brain injuries in a large cohort of very preterm and extremely preterm infants at term-equivalent age: results of a single tertiary neonatal care center over 10 years |
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| Συγγραφείς: | Drommelschmidt, Karla, Mayrhofer, Thomas, Hüning, Britta, Stein, Anja, Foldyna, Borek, Schweiger, Bernd, Felderhoff-Müser, Ursula, Sirin, Selma |
| Συνεισφορές: | University of Zurich, Sirin, Selma |
| Πηγή: | Eur Radiol |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, 2. Zero hunger, Incidence, Medizin, Infant, Newborn, 610 Medicine & health, Gestational Age, Infant, Premature, Diseases, Infant, Newborn [MeSH], Female [MeSH], Infant, Premature [MeSH], Preterm infants, Brain Injuries/diagnostic imaging [MeSH], Brain, Humans [MeSH], Tertiary Care Centers [MeSH], Infant, Extremely Premature [MeSH], Incidence [MeSH], Retrospective Studies [MeSH], Infant, Premature, Diseases/epidemiology [MeSH], Male [MeSH], Infant, Premature, Diseases/diagnostic imaging [MeSH], Magnetic resonance imaging, Magnetic Resonance Imaging/methods [MeSH], Magnetic Resonance, Brain Injuries/epidemiology [MeSH], Brain injuries, Gestational Age [MeSH], Magnetic Resonance Imaging, 3. Good health, Tertiary Care Centers, 10036 Medical Clinic, Infant, Extremely Premature, Brain Injuries, 2741 Radiology, Nuclear Medicine and Imaging, Humans, Female, Infant, Premature, Retrospective Studies |
| Περιγραφή: | Objectives Cerebral magnetic resonance imaging (cMRI) at term-equivalent age (TEA) can detect brain injury (BI) associated with adverse neurological outcomes in preterm infants. This study aimed to assess BI incidences in a large, consecutive cohort of preterm infants born Methods We retrospectively analyzed cMRIs at TEA of VPT and EPT infants born at a large tertiary center (2009–2018). We recorded and compared the incidences of BI, severe BI, intraventricular hemorrhage (IVH), periventricular hemorrhagic infarction (PVHI), cerebellar hemorrhage (CBH), cystic periventricular leukomalacia (cPVL), and punctate white matter lesions (PWML) between VPTs, EPTs, and across weeks of gestation. Results We included 507 preterm infants (VPT, 335/507 (66.1%); EPT, 172/507 (33.9%); mean gestational age (GA), 28 + 2 weeks (SD 2 + 2 weeks); male, 52.1%). BIs were found in 48.3% of the preterm infants (severe BI, 12.0%) and increased with decreasing GA. IVH, PVHI, CBH, cPVL, and PWML were seen in 16.8%, 0.8%, 10.5%, 3.4%, and 18.1%, respectively. EPT vs. VPT infants suffered more frequently from BI (59.3% vs. 42.7%, p p = 0.001), IVH (31.9% vs. 9.0%, p p Conclusion Brain injuries are common cMRI findings among preterm infants with a higher incidence of EPT compared to VPT infants. These results may serve as reference values for clinical management and research. Clinical relevance statement Our results with regard to gestational age might provide valuable clinical insights, serving as a key reference for parental advice, structured follow-up planning, and enhancing research and management within the Neonatal Intensive Care Unit. Key Points • Brain injury is a common cMRI finding in preterm infants seen in 48.3% individuals. • Extremely preterm compared to very preterm infants have higher brain injury incidences driven by brain injuries such as intraventricular and cerebellar hemorrhage. • Reference incidence values are crucial for parental advice and structured follow-up planning. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | s00330_024_10592_z__1_.pdf - application/pdf |
| Γλώσσα: | English |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-024-10592-z |
| DOI: | 10.5167/uzh-260221 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38279057 https://repository.publisso.de/resource/frl:6524632 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....64c56819c1dcf64c3f571d6d0baec067 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14321084 |
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| DOI: | 10.1007/s00330-024-10592-z |