Academic Journal
Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients
| Τίτλος: | Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients |
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| Συγγραφείς: | Timothy Lawn, Alessio Giacomel, Daniel Martins, Mattia Veronese, Matthew Howard, Federico E. Turkheimer, Ottavia Dipasquale |
| Πηγή: | Commun Biol Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024) |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Adult, Male, Bipolar Disorder, Attention Deficit Disorder with Hyperactivity/physiopathology, Nerve Net/physiopathology, QH301-705.5, Mental Disorders/physiopathology, Models, Neurological, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Models, Humans, Biology (General), Brain/physiopathology, Mental Disorders, Brain, Bipolar Disorder/physiopathology, Middle Aged, Schizophrenia/physiopathology, Magnetic Resonance Imaging, Attention Deficit Disorder with Hyperactivity, Neurological, Schizophrenia, Female, Nerve Net |
| Περιγραφή: | Advanced methods such as REACT have allowed the integration of fMRI with the brain’s receptor landscape, providing novel insights transcending the multiscale organisation of the brain. Similarly, normative modelling has allowed translational neuroscience to move beyond group-average differences and characterise deviations from health at an individual level. Here, we bring these methods together for the first time. We used REACT to create functional networks enriched with the main modulatory, inhibitory, and excitatory neurotransmitter systems and generated normative models of these networks to capture functional connectivity deviations in patients with schizophrenia, bipolar disorder (BPD), and ADHD. Substantial overlap was seen in symptomatology and deviations from normality across groups, but these could be mapped into a common space linking constellations of symptoms through to underlying neurobiology transdiagnostically. This work provides impetus for developing novel biomarkers that characterise molecular- and systems-level dysfunction at the individual level, facilitating the transition towards mechanistically targeted treatments. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-024-06391-3 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38839931 https://doaj.org/article/3b40dbfe1683459db0a08df6dbdcf850 https://hdl.handle.net/11577/3523938 https://doi.org/10.1038/s42003-024-06391-3 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....619ae533b1fc0baa08577b8e14807639 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 23993642 |
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| DOI: | 10.1038/s42003-024-06391-3 |