Academic Journal
Site-Specific Analysis of the Incidence Rate of Enterotoxigenic Escherichia coli Infection Elucidates an Association with Childhood Stunting, Wasting, and Being Underweight: A Secondary Analysis of the MAL-ED Birth Cohort
| Τίτλος: | Site-Specific Analysis of the Incidence Rate of Enterotoxigenic Escherichia coli Infection Elucidates an Association with Childhood Stunting, Wasting, and Being Underweight: A Secondary Analysis of the MAL-ED Birth Cohort |
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| Συγγραφείς: | Md. Ahshanul Haque, Sabiha Nasrin, Parag Palit, Rina Das, Barbie Zaman Wahid, Md. Amran Gazi, Mustafa Mahfuz, Abu Syed Golam Faruque, Tahmeed Ahmed |
| Πηγή: | Am J Trop Med Hyg |
| Στοιχεία εκδότη: | American Society of Tropical Medicine and Hygiene, 2023. |
| Έτος έκδοσης: | 2023 |
| Θεματικοί όροι: | FOS: Health sciences, Tanzania, Pediatrics, Cohort Studies, Endocrinology, Underweight, Child, Asymptomatic Infections, Pathogenesis and Virulence of Escherichia coli, Internal medicine, Escherichia coli Infections, Growth Disorders, Body mass index, Water Science and Technology, Environmental planning, 2. Zero hunger, Nutrition and Dietetics, Waterborne Disease Outbreaks and Pathogen Transport, Geography, Incidence, Incidence (geometry), Physics, Cohort, Life Sciences, bacterial invasion, 3. Good health, Asymptomatic, Physical Sciences, Medicine, Birth Cohort, Human and Clinical Nutrition, Research Article, and Biochemical Nutrition, Other Nutrition, Nursing, Environmental Enteropathy, Genetic, Thinness, Biochemistry, Genetics and Molecular Biology, Health Sciences, Humans, Enterotoxigenic Escherichia coli, Nutrition, Maternal and Child Nutrition in Developing Countries, Malnutrition, Molecular, Infant, Optics, Maternal and Child Undernutrition, Overweight, Wasting, Intestinal Diseases, Environmental Science, Malnutrition Impacts |
| Περιγραφή: | Asymptomatic infection by fecal enteropathogens is a major contributor to childhood malnutrition. Here, we investigated the incidence rate of asymptomatic infection by enterotoxigenic Escherichia coli (ETEC) and assessed its association with childhood stunting, wasting, and being underweight among children under 2 years of age. The Malnutrition and Enteric Disease birth cohort study included 1,715 children who were followed from birth to 24 months of age from eight distinct geographic locations including Bangladesh, Brazil, India, Peru, Tanzania, Pakistan, Nepal, and South Africa. The TaqMan array card assay was used to determine the presence of ETEC in the nondiarrheal stool samples collected from these children. Poisson regression was used to estimate the incidence rate, and multiple generalized estimating equations with binomial family, logit link function, and exchangeable correlation were used to analyze the association between asymptomatic ETEC infection and anthropometric indicators such as stunting, wasting, and being underweight. The site-specific incidence rates of asymptomatic ETEC infections per 100 child-months were also higher at the study locations in Tanzania (54.81 [95% CI: 52.64, 57.07]) and Bangladesh (46.75 [95% CI: 44.75, 48.83]). In the Bangladesh, India, and Tanzania sites, the composite indicator of anthropometric failure was significantly associated with asymptomatic ETEC infection. Furthermore, a significant association between asymptomatic heat-stable toxin ETEC infections and childhood stunting, wasting, and being underweight was found in only the Bangladesh and Tanzania sites. |
| Τύπος εγγράφου: | Article Conference object Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.22-0659 |
| DOI: | 10.60692/7139t-93f87 |
| DOI: | 10.60692/r6dzz-mtt41 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/37011892 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....5a1da641e805ddfc497f2bebd5d3fdfe |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.22-0659 |