Academic Journal
Association between recent real‐life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes: Findings from the Hypo‐RESOLVE clamp study: Findings from the Hypo-RESOLVE clamp study
| Title: | Association between recent real‐life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes: Findings from the Hypo‐RESOLVE clamp study: Findings from the Hypo-RESOLVE clamp study |
|---|---|
| Authors: | Cecilie H. Svensson, Therese W. Fabricius, Clementine Verhulst, Cees J. Tack, Peter L. Kristensen, Bastiaan E. de Galan, Ulrik Pedersen‐Bjergaard |
| Source: | Svensson, C H, Fabricius, T W, Verhulst, C, Tack, C J, Kristensen, P L, de Galan, B E, Pedersen-Bjergaard, U & the Hypo-RESOLVE consortium 2025, ' Association between recent real-life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes : Findings from the Hypo-RESOLVE clamp study ', Diabetes, Obesity and Metabolism, vol. 27, no. 10, pp. 5455-5463 . https://doi.org/10.1111/dom.16587 |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | type 1 diabetes, continuous glucose monitoring, hyperinsulinaemic-hypoglycaemic clamp, cognitive decline, cognitive function, hypoglycaemia |
| Description: | AimsCognitive decline during hypoglycaemia poses a risk for severe hypoglycaemia among people with type 1 diabetes, as it may compromise the ability to self‐treat and recover. Antecedent hypoglycaemia has been associated with blunted counterregulatory responses to subsequent hypoglycaemia, but whether hypoglycaemia‐induced cognitive dysfunction is subject to such a process of habituation is unclear. We investigated the association between recent real‐life exposure to hypoglycaemia recorded by continuous glucose monitoring (CGM) and cognitive function during a hypoglycaemic clamp.Materials and MethodsForty‐two people with type 1 diabetes were given open intermittently scanned CGM (Freestyle Libre 1®) to record real‐life hypoglycaemia for a week before participating in a hyperinsulinaemic‐euglycaemic‐hypoglycaemic clamp (mean ± SD) (2.8 ± 0.1 mmol/L). We assessed cognitive function at baseline and during hypoglycaemia using four validated tests: Paced Auditory Serial Addition Test (PASAT) and three subtasks of Test of Attentional Performance (TAP)—Alertness, Verbal Flexibility, and Working Memory.ResultsHypoglycaemia exposure (glucose p 1c and hypoglycaemia awareness status in linear regression analyses.ConclusionsOur findings indicate that recent real‐life CGM‐recorded hypoglycaemia is not associated with cognitive decline during clamped hypoglycaemia in people with type 1 diabetes. This suggests that cognitive decline during hypoglycaemia is not susceptible to habituation. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1463-1326 1462-8902 |
| DOI: | 10.1111/dom.16587 |
| Access URL: | https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/322945 https://doi.org/10.1111/dom.16587 https://cris.maastrichtuniversity.nl/en/publications/25433e5b-327e-4894-8c49-6b014efcd77a https://doi.org/10.1111/dom.16587 https://curis.ku.dk/ws/files/483934644/Diabetes_Obesity_Metabolism_-_2025_-_Svensson_-_Association_between_recent_real_life_exposure_to_hypoglycaemia_and.pdf |
| Rights: | CC BY NC |
| Accession Number: | edsair.doi.dedup.....52aaea5016f4effe09cfda75133a57d7 |
| Database: | OpenAIRE |
| ISSN: | 14631326 14628902 |
|---|---|
| DOI: | 10.1111/dom.16587 |