Academic Journal
Transfusion-Transmitted Hepatitis E Virus Infection in France
| Title: | Transfusion-Transmitted Hepatitis E Virus Infection in France |
|---|---|
| Authors: | Gallian, Pierre, Pouchol, Elodie, Djoudi, Rachid, Lhomme, Sébastien, Mouna, Lina, Gross, Sylvie, Bierling, Philippe, Assal, Azzedine, Kamar, Nassim, Mallet, Vincent, Roque-Afonso, Anne-Marie, Izopet, Jacques, Tiberghien, Pierre |
| Contributors: | CCSD, Accord Elsevier, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement Français du Sang La Plaine Saint-Denis (EFS), Laboratoire Virologie CHU Toulouse, Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Virologie Villejuif, Hôpital Paul Brousse, Etablissement Français du Sang (EFS) Créteil, Etablissement Français du Sang Nouvelle Aquitaine Bordeaux (EFS Bordeaux Nouvelle Aquitaine), Département de Néphrologie et Transplantation d'organes CHU Toulouse, Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Paris Descartes, Sorbonne Paris Cité, Physiopathologie du système immunitaire (Inserm U1223), Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie médicale CHU Cochin, Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC) |
| Source: | Transfusion Medicine Reviews. 33:146-153 |
| Publisher Information: | Elsevier BV, 2019. |
| Publication Year: | 2019 |
| Subject Terms: | Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], MESH: Blood Donors / statistics & numerical data, Blood Donors, Severity of Illness Index, MESH: Risk Factors, Risk Factors, MESH: Child, 80 and over, Child, MESH: Blood Safety / statistics & numerical data, MESH: Aged, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Aged, 80 and over, MESH: France / epidemiology, MESH: Middle Aged, Middle Aged, Hepatitis E, 3. Good health, [SDV] Life Sciences [q-bio], MESH: Transfusion Reaction / diagnosis, MESH: Young Adult, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Acute Disease, MESH: Acute Disease, Female, France, Transfusion-transmitted infection, Adult, Adolescent, Blood Safety, MESH: Hepatitis E / diagnosis, Young Adult, 03 medical and health sciences, MESH: Severity of Illness Index, Hepatitis E virus, Humans, Aged, Retrospective Studies, MESH: Adolescent, MESH: Hepatitis E / epidemiology, MESH: Humans, MESH: Chronic Disease, MESH: Hepatitis E / transmission, MESH: Transfusion Reaction / epidemiology, Transfusion Reaction, MESH: Adult, MESH: Retrospective Studies, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Chronic Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female |
| Description: | There is growing concern regarding the risk of transfusion- transmitted (TT) hepatitis E. Since the first described case in 2006, several TT hepatitis E have been reported to the French hemovigilance network. We performed a retrospective analysis of all cases of TT hepatitis E reported between 2006 and 2016. Transfusion-transmitted hepatitis E with high imputability according to phylogenetic analysis occurred in 23 patients aged 8 to 88 years and involved mostly solid organ recipients (n = 9) or patients with malignant hematological diseases (n = 9, including 4 hematopoietic allograft recipients). Involved blood products were plasma (n = 7), among which 6 had undergone pathogen reduction with solvent/detergent (n = 4) or amotosalen + ultra-violet A (UVA) (n = 2 from 1 donation) treatments, red blood concentrates (n = 7), apheresis platelets concentrates (n = 3) and whole blood pooled platelets concentrates (n = 6), among which one had underwent amotosalen + UVA treatment. Median hepatitis E virus (HEV) RNA dose infused was 5.79 [4.36-10.10] log IU. HEV infection progressed to chronic hepatitis E in 14 (61%) immunocompromised patients, 2 of whom had advanced liver fibrosis at diagnosis. Chronic hepatitis E patients cleared HEV with ribavirin treatment (n = 10), after immunosuppressive drug reduction (n = 3), or spontaneously (n = 1). One additional organ transplant recipient with associated co-morbidities died with ongoing HEV infection and multiple organ failure. The other 8 (34.8%) patients with TT hepatitis E cleared HEV within 6 months with ribavirin treatment (n = 3), reduced immunosuppression (n = 1) or spontaneously (n = 4). Red cells, platelets, and plasma transfusions may be associated with TT hepatitis E that can evolve to chronic hepatitis E in immunocompromised patients. Hepatitis E virus has emerged in France as a clinically significant TT infection risk. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0887-7963 |
| DOI: | 10.1016/j.tmrv.2019.06.001 |
| Access URL: | https://www.sciencedirect.com/science/article/am/pii/S0887796319300343 https://pubmed.ncbi.nlm.nih.gov/31327668 https://www.sciencedirect.com/science/article/pii/S0887796319300343 https://europepmc.org/article/MED/31327668 https://www.ncbi.nlm.nih.gov/pubmed/31327668 https://pubmed.ncbi.nlm.nih.gov/31327668/ https://hal.science/hal-02227820v1/document https://hal.science/hal-02227820v1 https://doi.org/10.1016/j.tmrv.2019.06.001 |
| Rights: | Elsevier TDM CC BY NC |
| Accession Number: | edsair.doi.dedup.....40d57f5e6ff5366564ec63210907258c |
| Database: | OpenAIRE |
| ISSN: | 08877963 |
|---|---|
| DOI: | 10.1016/j.tmrv.2019.06.001 |