Academic Journal
Low adherence to recommended use of neoadjuvant chemotherapy for muscle-invasive bladder cancer
| Τίτλος: | Low adherence to recommended use of neoadjuvant chemotherapy for muscle-invasive bladder cancer |
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| Συγγραφείς: | Lisa M. C. van Hoogstraten, Calvin C. O. Man, J. Alfred Witjes, Richard P. Meijer, Sasja F. Mulder, Tineke J. Smilde, Theodora M. Ripping, Lambertus A. Kiemeney, Katja K. H. Aben, Joost L. Boormans, Catharina A. Goossens-Laan, Antoine G. van der Heijden, Michiel S. van der Heijden, Sipke Helder, Tom J. N. Hermans, Maarten C. C. M. Hulshof, Anna M. Leliveld, Geert J. L. H. van Leenders, Reindert J. A. van Moorselaar, Juus L. Noteboom, Jorg R. Oddens, Theo M. de Reijke, Bas W. G. van Rhijn, Joep G. H. van Roermund, Guus W. J. Venderbosch, Bart P. Wijsman |
| Πηγή: | World J Urol BlaZIB Study Group 2023, 'Low adherence to recommended use of neoadjuvant chemotherapy for muscle-invasive bladder cancer', World Journal of Urology, vol. 41, no. 7, pp. 1837-1845. https://doi.org/10.1007/s00345-023-04443-7 World Journal of Urology, 41, 7, pp. 1837-1845 |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2023. |
| Έτος έκδοσης: | 2023 |
| Θεματικοί όροι: | Radboudumc 15: Urological cancers Urology, Radboudumc 15: Urological cancers Health Evidence, Bladder carcinoma, Muscles, Urinary Bladder, Radboud University Medical Center, Guideline adherence, Variation in healthcare, Cystectomy, Neoadjuvant chemotherapy, Neoadjuvant Therapy, 3. Good health, MIBC, Radical cystectomy, SDG 3 - Good Health and Well-being, Urinary Bladder Neoplasms, Chemotherapy, Adjuvant, Radboudumc 0: Other Research Medical Oncology, Humans, Original Article, Neoplasm Invasiveness, Radboudumc 15: Urological cancers Primary and Community Care, Muscle-invasive bladder cancer, Retrospective Studies |
| Περιγραφή: | Purpose To evaluate guideline adherence and variation in the recommended use of neoadjuvant chemotherapy (NAC) and the effects of this variation on survival in patients with non-metastatic muscle-invasive bladder cancer (MIBC). Patients and methods In this nationwide, Netherlands Cancer Registry-based study, we identified 1025 patients newly diagnosed with non-metastatic MIBC between November 2017 and November 2019 who underwent radical cystectomy. Patients with ECOG performance status 0–1 and creatinine clearance ≥ 50 mL/min/1.73 m2 were considered NAC-eligible. Interhospital variation was assessed using case-mix adjusted multilevel analysis. A Cox proportional hazards model was used to evaluate the association between hospital specific probability of using NAC and survival. All analyses were stratified by disease stage (cT2 versus cT3-4a). Results In total, of 809 NAC-eligible patients, only 34% (n = 277) received NAC. Guideline adherence for NAC in cT2 was 26% versus 55% in cT3-4a disease. Interhospital variation was 7–57% and 31–62%, respectively. A higher hospital specific probability of NAC might be associated with a better survival, but results were not statistically significant (HRcT2 = 0.59, 95% CI 0.33–1.05 and HRcT3-4a = 0.71, 95% CI 0.25–2.04). Conclusion Guideline adherence regarding NAC use is low and interhospital variation is large, especially for patients with cT2-disease. Although not significant, our data suggest that survival of patients diagnosed in hospitals more inclined to give NAC might be better. Further research is warranted to elucidate the underlying mechanism. As literature clearly shows the potential survival benefit of NAC in patients with cT3-4a disease, better guideline adherence might be pursued. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-023-04443-7 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/37258902 https://pure.eur.nl/en/publications/a50784b4-6fde-41ea-a3e8-d0b8abccb3c6 https://doi.org/10.1007/s00345-023-04443-7 https://www.scopus.com/pages/publications/85160726683 https://research.vumc.nl/en/publications/cf0cf922-7eb6-4267-aff4-92739cd320d5 https://doi.org/10.1007/s00345-023-04443-7 https://pure.amsterdamumc.nl/en/publications/b4ba773c-5829-48c7-b287-f117853c18dd https://doi.org/10.1007/s00345-023-04443-7 https://repository.ubn.ru.nl//bitstream/handle/2066/294939/294939.pdf https://hdl.handle.net/2066/294939 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....3d6b82f2d87c4fa623719d353a0c1e5b |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14338726 |
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| DOI: | 10.1007/s00345-023-04443-7 |