Academic Journal
Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma
| Title: | Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma |
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| Authors: | Cheol Keun Park, Woo Hee Jung, Ja Seung Koo |
| Contributors: | College of Medicine, Dept. of Pathology, Cheol Keun Park, Woo Hee Jung, Ja Seung Koo, Koo, Ja Seung, Jung, Woo Hee |
| Source: | Breast Cancer Research and Treatment. 159:55-69 |
| Publisher Information: | Springer Science and Business Media LLC, 2016. |
| Publication Year: | 2016 |
| Subject Terms: | Receptor, Platelet-Derived Growth Factor alpha, Lobular/pathology, Breast cancer, 0302 clinical medicine, Cancer-Associated Fibroblasts, Ductal, Breast/metabolism, Gelatinases/metabolism, Membrane Glycoproteins, Breast Neoplasms/pathology, Carcinoma, Ductal, Breast, Serine Endopeptidases, Membrane Glycoproteins/metabolism, Invasive lobular carcinoma, 3. Good health, Platelet-Derived Growth Factor alpha/metabolism, Gelatinases, Prolyl Hydroxylases/metabolism, Female, Proteoglycans, Cancer-Associated Fibroblasts/pathology, Receptor, Invasive ductal carcinoma, Cancer-associated fibroblast, S100 Calcium-Binding Protein A4/metabolism, Breast Neoplasms, Prolyl Hydroxylases, Receptor, Platelet-Derived Growth Factor beta, Serine Endopeptidases/metabolism, 03 medical and health sciences, Endopeptidases, Biomarkers, Tumor, Humans, S100 Calcium-Binding Protein A4, Tumor stroma, Antigens, Cancer-Associated Fibroblasts/metabolism, Carcinoma, Lobular/metabolism, Platelet-Derived Growth Factor beta/metabolism, Membrane Proteins, Proteoglycans/metabolism, Carcinoma, Lobular, Breast Neoplasms/metabolism, Tissue Array Analysis, Breast/pathology, Tumor/metabolism, Membrane Proteins/metabolism, Antigens/metabolism, Biomarkers |
| Description: | Cancer-associated fibroblasts (CAFs) are classified into various functional subtypes such as fibroblast activation protein-α (FAP-α), fibroblast specific protein-1 (FSP-1), platelet-derived growth factor receptor-α (PDGFR-α), and PDGFR-β. In this study, we compared the expression of CAF-related proteins in invasive lobular carcinoma (ILC) with those in invasive carcinoma of no special type (NST) and assessed the implications of the differences observed. Using tissue microarrays of 104 ILC and 524 invasive carcinoma (NST) cases, immunohistochemistry for CAF-related proteins [podoplanin, prolyl 4-hydroxylase, FAP-α, FSP-1/S100A4, PDGFR-α, PDGFR-β, and chondroitin sulfate proteoglycan (NG2)] was conducted. In invasive carcinoma (NST), tumor cells expressed a high level of PDGFR-α, whereas ILC tumor cells expressed high levels of podoplanin, prolyl 4-hydroxylase, FAP-α, and FSP-1/S100A4. In stromal cells of invasive carcinoma (NST), high expression levels of prolyl 4-hydroxylase, PDGFR-α, and NG2 were observed, whereas ILC stromal cells expressed high levels of FAP-α, FSP-1/S100A4, and PDGFR-β. In ILC, tumoral FSP-1/S100A4 positivity was associated with higher Ki-67 labeling index (p = 0.010) and non-luminal A type cancer (p = 0.014). Stromal PDGFR-α positivity was associated with lymph node metastasis (p = 0.011). On survival analysis of entire cases, tumoral FSP-1/S100A4 positivity (p = 0.002), stromal podoplanin positivity (p = 0.041), and stromal FSP-1/S100A4 negativity (p = 0.041) were associated with shorter disease-free survival; only tumoral FSP-1/S100A4 positivity (p = 0.044) was associated with shorter overall survival. In ILC, the expression of FAP-α and FSP-1/S100A4 was higher in both tumor and stromal cells than that observed in invasive carcinoma (NST). These results indicate that CAFs are a potential target in ILC treatment. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-016-3929-2 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/27469595 https://ir.ymlib.yonsei.ac.kr/handle/22282913/151955?mode=simple http://europepmc.org/abstract/MED/27469595 http://cancerres.aacrjournals.org/content/77/6_Supplement/A40 https://pubmed.ncbi.nlm.nih.gov/27469595/ https://link.springer.com/article/10.1007/s10549-016-3929-2/fulltext.html https://yonsei.pure.elsevier.com/en/publications/expression-of-cancer-associated-fibroblast-related-proteins-diffe |
| Rights: | Springer TDM CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....315caa0679b8100cdb83c5a8768f3357 |
| Database: | OpenAIRE |
| ISSN: | 15737217 01676806 |
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| DOI: | 10.1007/s10549-016-3929-2 |