The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019: a systematic analysis for the Global Burden of Disease Study 2019
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:
The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019: a systematic analysis for the Global Burden of Disease Study 2019
GBD 2019 Adolescent Young Adult Cancer Collaborators, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), RUN, HUS Comprehensive Cancer Center, University of Helsinki, Współautorami artykułu są członkowie GBD 2019 Adolescent Young Adult Cancer Collaborators w liczbie 729, Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick’s Foundation, National Cancer Institute (NCI), National Institutes of Health, ACU Research Bank, Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division, Statistics Program, Elysia M Alvarez, Lisa M Force, Rixing Xu, Kelly Compton, Dan Lu, Hannah Jacqueline Henrikson, Jonathan M Kocarnik, James D Harvey, Alyssa Pennini, Frances E Dean, Weijia Fu, Martina T Vargas, Theresa H M Keegan, Hany Ariffin, Ronald D Barr, Yana Arturovna Erdomaeva, D Sanjeeva Gunasekera, Yetunde O John-Akinola, Tyler G Ketterl, Tezer Kutluk, Marcio Henrique Malogolowkin, Prashant Mathur, Venkatraman Radhakrishnan, Lynn Ann Gloeckler Ries, Carlos Rodriguez-Galindo, Garik Barisovich Sagoyan, Iyad Sultan, Behzad Abbasi, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Michael Abdelmasseh, Sherief Abd-Elsalam, Amir Abdoli, Haimanot Abebe, Aidin Abedi, Hassan Abidi, Hassan Abolhassani, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Basavaprabhu Achappa, Juan Manuel Acuna, Isaac Akinkunmi Adedeji, Oyelola A Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Muhammad Sohail Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Sepideh Ahmadi, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Yusra Ahmed Salih, Wajeeha Aiman, Gizachew Taddesse Akalu, Hanadi Al Hamad, Fares Alahdab, Abdulhadi A AlAmodi, Fahad Mashhour Alanezi, Turki M Alanzi, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Yosef Alemayehu, Fadwa Naji Alhalaiqa, Robert Kaba Alhassan, Saqib Ali, Gianfranco Alicandro, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sunitha Alluri, Nihad A Almasri, Sadeq Ali Al-Maweri, Sami Almustanyir, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Edward Kwabena Ameyaw, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Fereshteh Ansari, Alireza Ansari-Moghaddam, Davood Anvari, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Muhammad Arshad, Judie Arulappan, Armin Aryannejad, Zatollah Asemi, Mohammad Asghari Jafarabadi, Mohammad Reza Atashzar, Prince Atorkey, Alok Atreya, Sameh Attia, 2019 Adolescent Young Adult Cancer Collaborators, Gbd, D'Amico, Emanuele, Elysia, M Alvarez, Lisa, M Force, Rixing, Xu, Compton, Kelly, Dan, Lu, Jonathan, M Kocarnik, James, D Harvey, Pennini, Alyssa, Frances, E Dean, Weijia, Fu, Martina, T Varga, Theresa H, M Keegan, Ariffin, Hany, Ronald, D Barr, Yetunde, O John-Akinola, Tyler, G Ketterl, Kutluk, Tezer, Mathur, Prashant, Radhakrishnan, Venkatraman, Rodriguez-Galindo, Carlo, Sultan, Iyad, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdoli, Amir, Abebe, Haimanot, Abedi, Aidin, Abidi, Hassan, Abolhassani, Hassan, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Oyelola, A Adegboye, Shailesh, M Advani, Ahadinezhad, Bahman, Ahmad, Sajjad, Ahmadi, Sepideh, Aiman, Wajeeha, Alahdab, Fare, Abdulhadi, A AlAmodi, Turki, M Alanzi, Alemayehu, Yosef, Ali, Saqib, Alicandro, Gianfranco, Alipour, Vahid, Alkhayyat, Motasem, Alluri, Sunitha, Nihad, A Almasri, Almustanyir, Sami, Rajaa, M Al-Raddadi, Alvis-Guzman, Nelson, Amini, Saeed, Amu, Hubert, Ancuceanu, Robert, Andrei, Tudorel, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Anvari, Davood, Arabloo, Jalal, Arab-Zozani, Morteza, Arshad, Muhammad, Arulappan, Judie, Aryannejad, Armin, Asemi, Zatollah, Atorkey, Prince, Atreya, Alok, Attia, Sameh, M Alvarez, Elysia, M Force, Lisa, Xu, Rixing, Lu, Dan, Jacqueline Henrikson, Hannah, M Kocarnik, Jonathan, D Harvey, Jame, E Dean, France, Fu, Weijia, T Vargas, Martina, M Keegan, Theresa H, D Barr, Ronald, Arturovna Erdomaeva, Yana, Sanjeeva Gunasekera, D, O John-Akinola, Yetunde, G Ketterl, Tyler, Henrique Malogolowkin, Marcio, Ann Gloeckler Ries, Lynn, Barisovich Sagoyan, Garik, Abubaker Ali, Hiwa, Manuel Acuna, Juan, Akinkunmi Adedeji, Isaac, A Adegboye, Oyelola, Estiningtyas Sakilah Adnani, Qorinah, M Advani, Shailesh, Sohail Afzal, Muhammad, Aghaie Meybodi, Mohamad, Opoku Ahinkorah, Bright, Beshir Ahmed, Muktar, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Taddesse Akalu, Gizachew, Al Hamad, Hanadi, A AlAmodi, Abdulhadi, Mashhour Alanezi, Fahad, M Alanzi, Turki, Zeleke Alem, Adugnaw, Tsegaye Alem, Dejene, Naji Alhalaiqa, Fadwa, Kaba Alhassan, Robert, Mohamed Aljunid, Syed, A Almasri, Nihad, Ali Al-Maweri, Sadeq, M Al-Raddadi, Rajaa, Kwabena Ameyaw, Edward, Liliana Andrei, Catalina, Edward Anyasodor, Anayochukwu, Mamo Argaw, Ayele, Asghari Jafarabadi, Mohammad, Reza Atashzar, Mohammad
Πηγή:
Lancet Oncol LANCET ONCOLOGY r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu GBD 2019 Adolescent Young Adult Cancer Collaborators 2022, 'The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019', Lancet Oncology, vol. 23, no. 1, pp. 27-52. https://doi.org/10.1016/S1470-2045(21)00581-7 The Lancet Oncology, vol 23, iss 1
In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults.Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults.There were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9-15·6] per 100 000 person-years) and middle SDI (13·6 [12·6-14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9-25·2) DALYs to the global burden of disease, of which 2·7% (1·9-3·6) came from YLDs and 97·3% (96·4-98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally.Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts.Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute.