Academic Journal
Automated segmentation for cortical thickness of the medial perirhinal cortex
| Τίτλος: | Automated segmentation for cortical thickness of the medial perirhinal cortex |
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| Συγγραφείς: | Henzen, N.A., Abdulkadir, A., Reinhardt, J., Blatow, M., Kressig, R.W., Krumm, S. |
| Πηγή: | Sci Rep Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025) Scientific reports, vol. 15, no. 1, pp. 14903 |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Male, Adult, Science, 616.8: Neurologie und Krankheiten des Nervensystems, 006: Spezielle Computerverfahren, Article, Perirhinal cortex, Alzheimer Disease, Image Processing, Computer-Assisted, Humans, Entorhinal Cortex, Cognitive Dysfunction, Aged, Perirhinal Cortex, Entorhinal cortex, Aged, 80 and over, Female, Alzheimer Disease/pathology, Alzheimer Disease/diagnostic imaging, Magnetic Resonance Imaging/methods, Cognitive Dysfunction/pathology, Cognitive Dysfunction/diagnostic imaging, Perirhinal Cortex/diagnostic imaging, Perirhinal Cortex/pathology, Middle Aged, Entorhinal Cortex/pathology, Entorhinal Cortex/diagnostic imaging, Image Processing, Computer-Assisted/methods, Alzheimer's disease, Deep learning, Semantic segmentation, Structural MRI, Magnetic Resonance Imaging, Medicine |
| Περιγραφή: | Alzheimer's disease (AD) is characterized by a progressive spread of neurofibrillary tangles (NFT), beginning in the medial perirhinal cortex (mPRC), advancing to the entorhinal cortex (ERC), and subsequently involving the hippocampus, lateral perirhinal cortex (lPRC), and the rest of the brain. Given the close relationship between NFT accumulation and neuronal loss, the mPRC reflects a promising structural marker for early diagnosis of AD. However, only limited tools that automatically measure the cortical thickness of the mPRC are currently available. Utilizing the nnU-Net framework, we trained models on structural MRI of 126 adults, with manually segmented labels as ground truth. These models were then applied to an independent dataset of 103 adults (comprising patients with Alzheimer's dementia, amnestic mild cognitive impairment (aMCI), and healthy controls). High agreement was observed between manual and automated measurements of cortical thickness. Furthermore, we found significant atrophy in the Alzheimer's dementia group in the mPRC, ERC, and lPRC compared to healthy controls. Comparison of the aMCI group and healthy controls revealed significant differences in the ERC only. The results underscore the utility of our automated segmentation tool in advancing Alzheimer's research. Nicolas A. Henzen and Ahmed Abdulkadir contributed equally. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-98399-w |
| DOI: | 10.48620/88573 |
| DOI: | 10.21256/zhaw-33298 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/40295570 https://doaj.org/article/29f97b4e385a410c961e7f3de8d75044 https://serval.unil.ch/notice/serval:BIB_B96D71A9752A https://serval.unil.ch/resource/serval:BIB_B96D71A9752A.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B96D71A9752A3 |
| Rights: | CC BY NC ND |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....2c1f2cd2136d724cf2995863420dd82a |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-025-98399-w |