Academic Journal
The correlation of urea and creatinine concentrations in sweat and saliva with plasma during hemodialysis: an observational cohort study: an observational cohort study
| Τίτλος: | The correlation of urea and creatinine concentrations in sweat and saliva with plasma during hemodialysis: an observational cohort study: an observational cohort study |
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| Συγγραφείς: | Sophie Adelaars, Constantijn J.A.M. Konings, Lieke Cox, Eva Boonen, Massimo Mischi, R. Arthur Bouwman, Daan van de Kerkhof |
| Πηγή: | Clinical Chemistry and Laboratory Medicine (CCLM). 62:1118-1125 |
| Στοιχεία εκδότη: | Walter de Gruyter GmbH, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, Adult, Urea/analysis, Biomarkers/analysis, Sweat/chemistry, Kidney Failure, Cohort Studies, hemodialysis at home, Renal Dialysis, Humans, Urea, Saliva, Sweat, Aged, biosensors for sweat analysis, Saliva/chemistry, Creatinine/blood, Middle Aged, continuous monitoring, diagnostics of urea in sweat and saliva, Chronic/therapy, 3. Good health, non-invasive monitoring, Creatinine, Kidney Failure, Chronic, Female, Biomarkers |
| Περιγραφή: | Objectives Urea and creatinine concentrations in plasma are used to guide hemodialysis (HD) in patients with end-stage renal disease (ESRD). To support individualized HD treatment in a home situation, there is a clinical need for a non-invasive and continuous alternative to plasma for biomarker monitoring during and between cycles of HD. In this observational study, we therefore established the correlation of urea and creatinine concentrations between sweat, saliva and plasma in a cohort of ESRD patients on HD. Methods Forty HD patients were recruited at the Dialysis Department of the Catharina Hospital Eindhoven. Sweat and salivary urea and creatinine concentrations were analyzed at the start and at the end of one HD cycle and compared to the corresponding plasma concentrations. Results A decrease of urea concentrations during HD was observed in sweat, from 27.86 mmol/L to 12.60 mmol/L, and saliva, from 24.70 mmol/L to 5.64 mmol/L. Urea concentrations in sweat and saliva strongly correlated with the concentrations in plasma (ρ 0.92 [p Conclusions The results illustrate a proof of principle of urea measurements in sweat and saliva to monitor HD adequacy in a non-invasive and continuous manner. Biosensors enabling urea monitoring in sweat or saliva could fill in a clinical need to enable at-home HD for more patients and thereby decrease patient burden. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2023-1285 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38253354 https://research.tue.nl/en/publications/00bd62b9-b233-4d36-b0b4-e28b71c26e98 https://doi.org/10.1515/cclm-2023-1285 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....2bd098bdbad7bda5d55ee2c44f5c8306 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14374331 14346621 |
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| DOI: | 10.1515/cclm-2023-1285 |