Academic Journal
Dopamine Modulates Auditory Responses in the Inferior Colliculus in a Heterogeneous Manner
| Τίτλος: | Dopamine Modulates Auditory Responses in the Inferior Colliculus in a Heterogeneous Manner |
|---|---|
| Συγγραφείς: | Gittelman, Joshua X, Perkel, David J, Portfors, Christine V |
| Πηγή: | Journal of the Association for Research in Otolaryngology. 14:719-729 |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2013. |
| Έτος έκδοσης: | 2013 |
| Θεματικοί όροι: | 0301 basic medicine, Dopamine - physiology, Auditory Pathways, Consciousness, Dopamine, Dopamine Agents, Action Potentials, Auditory Pathways - drug effects, Inferior Colliculi - drug effects, Mice, 03 medical and health sciences, Auditory Pathways - physiology, 0302 clinical medicine, Dopamine - pharmacology, Receptors, Reaction Time, Animals, Action Potentials - physiology, Action Potentials - drug effects, Evoked Potentials, Electrodes, Reaction Time - physiology, Inferior Colliculi - physiology, Receptors, Dopamine D2, Inbred CBA, Iontophoresis, Inferior Colliculi, Auditory - drug effects, Reaction Time - drug effects, Dopamine Agents - pharmacology, Auditory - physiology, Acoustic Stimulation, Evoked Potentials, Auditory, Mice, Inbred CBA, Female, Dopamine D2 - physiology |
| Περιγραφή: | Perception of complex sounds such as speech is affected by a variety of factors, including attention, expectation of reward, physiological state, and/or disorders, yet the mechanisms underlying this modulation are not well understood. Although dopamine is commonly studied for its role in reward-based learning and in disorders, multiple lines of evidence suggest that dopamine is also involved in modulating auditory processing. In this study, we examined the effects of dopamine application on neuronal response properties in the inferior colliculus (IC) of awake mice. Because the IC contains dopamine receptors and nerve terminals immunoreactive for tyrosine hydroxylase, we predicted that dopamine would modulate auditory responses in the IC. We recorded single-unit responses before, during, and after the iontophoretic application of dopamine using piggyback electrodes. We examined the effects of dopamine on firing rate, timing, and probability of bursting. We found that application of dopamine affected neural responses in a heterogeneous manner. In more than 80 % of the neurons, dopamine either increased (32 %) or decreased (50 %) firing rate, and the effects were similar on spontaneous and sound-evoked activity. Dopamine also either increased or decreased first spike latency and jitter in almost half of the neurons. In 3/28 neurons (11 %), dopamine significantly altered the probability of bursting. The heterogeneous effects of dopamine observed in the IC of awake mice were similar to effects observed in other brain areas. Our findings indicate that dopamine differentially modulates neural activity in the IC and thus may play an important role in auditory processing. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1438-7573 1525-3961 |
| DOI: | 10.1007/s10162-013-0405-0 |
| Σύνδεσμος πρόσβασης: | https://europepmc.org/articles/pmc3767870?pdf=render https://pubmed.ncbi.nlm.nih.gov/23835945 |
| Rights: | Springer TDM |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....26eaa65c95ebee9a916b2ea6c87bbcf7 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14387573 15253961 |
|---|---|
| DOI: | 10.1007/s10162-013-0405-0 |