Academic Journal
Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology
| Title: | Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology |
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| Authors: | Hye Min Kim, Ji Hee Lee, Ja Seung Koo |
| Contributors: | Lee J.H., Kim H.M., Koo J.S., Koo, Ja Seung |
| Source: | Pathobiology. 85:311-321 |
| Publisher Information: | S. Karger AG, 2018. |
| Publication Year: | 2018 |
| Subject Terms: | 0301 basic medicine, Cancer-associated fibroblast, Receptor, ErbB-2, Intraductal, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms, Stroma, Triple Negative Breast Neoplasms/metabolism, Noninfiltrating/metabolism, Noninfiltrating/pathology, Cancer-Associated Fibroblasts/pathology, 03 medical and health sciences, Cancer-Associated Fibroblasts, Ductal, Breast/metabolism, Receptors, Tumor/metabolism, Breast/diagnosis, Biomarkers, Tumor, Humans, Breast, 0303 health sciences, Carcinoma, Carcinoma, Ductal, Breast, Ductal carcinoma in situ, Cancer-Associated Fibroblasts/metabolism, Neoplastic/genetics, Middle Aged, 3. Good health, Gene Expression Regulation, Neoplastic, Carcinoma, Intraductal, Noninfiltrating, Gene Expression Regulation, Receptors, Estrogen, Breast/pathology, Progesterone/genetics, ErbB-2/metabolism, Progesterone/metabolism, Female, Estrogen/metabolism, Triple Negative Breast Neoplasms/genetics, Receptors, Progesterone, Biomarkers, Receptor |
| Description: | Objective: The purpose of this study is to investigate the expression of cancer-associated fibroblast (CAF)-related proteins and their implication in ductal carcinoma in situ (DCIS). Methods: We constructed a tissue microarray of 223 cases of DCIS and examined immunohistochemical staining for the 7 CAF-related proteins. We classified DCIS into luminal type, human epidermal growth factor receptor-2 (HER-2) type, and triple negative breast cancer (TNBC) according to the immunohistochemical results for estrogen receptor, progesterone receptor, and HER-2. We also classified DCIS into desmoplastic, normal-like, and inflammatory type according to stromal histology. Results: There were significant differences in the expression of S100A4, podoplanin, prolyl 4-hydroxylase subunit alpha 3, NG2, and PDGFRα in stromal cells of DCIS when classified according to molecular subtype. The expression rate of all CAF-related proteins in stromal cells was higher in the HER-2 type and TNBC than in the luminal type (p < 0.001). When classified according to stromal subtype, there were significant differences in the expression of all CAF-related proteins in stromal cells, with the inflammatory stromal type showing higher expression of CAF-related proteins than other stromal types. Conclusion: The expression of CAF-related proteins in stromal cells of DCIS varies according to molecular subtype and stromal type. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000492392 |
| Access URL: | https://www.karger.com/Article/Pdf/492392 https://pubmed.ncbi.nlm.nih.gov/30223270 https://pubmed.ncbi.nlm.nih.gov/30223270/ https://ir.ymlib.yonsei.ac.kr/handle/22282913/166684 https://yonsei.pure.elsevier.com/en/publications/differential-expression-of-cancer-associated-fibroblast-related-p-2 https://www.ncbi.nlm.nih.gov/pubmed/30223270 |
| Rights: | CC BY NC ND URL: https://www.karger.com/Services/SiteLicenses |
| Accession Number: | edsair.doi.dedup.....2648431615d1f38a8fffe7825080373f |
| Database: | OpenAIRE |
| ISSN: | 14230291 10152008 |
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| DOI: | 10.1159/000492392 |