Academic Journal
The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies
| Title: | The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies |
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| Authors: | Nahuel Paesano, Violeta Catalá, Larisa Tcholakian, Xavier Alomar, Miguel Barranco, Enric Trilla, Juan Morote |
| Contributors: | Institut Català de la Salut, [Paesano N, Catalá V, Tcholakian L, Alomar X, Barranco M] Creu Blanca Clinic Barcelona, Catalunya, Spain. [Trilla E, Morote J] Servei d’Urologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Department of Surgery, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Source: | Int Braz J Urol Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona International Brazilian Journal of Urology, Vol 50, Iss 3, Pp 296-308 (2024) |
| Publisher Information: | FapUNIFESP (SciELO), 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Image-Guided Biopsy, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Prostate, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Prostatic Neoplasms, Pròstata - Càncer - Imatgeria, Magnetic Resonance Imaging, Diseases of the genitourinary system. Urology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata, DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms, Humans, Pròstata - Biòpsia, Original Article, RC870-923, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Image-Guided Biopsy, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia guiada por imágenes, Retrospective Studies |
| Description: | To evaluate the effectiveness of mapping-targeted biopsies (MTB) on the index lesion for the detection of clinically significant prostate cancer (csPCa) in transperineal fusion-image prostate biopsies.A retrospective analysis was conducted on 309 men with suspected PCa who underwent prostate biopsies at the Creu Blanca reference center in Barcelona, Spain. The Prostate Imaging-Reporting and Data System (PI-RADS v.2.1) of the magnetic resonance images (MRI) were reclassified by an expert radiologist reading of pre-biopsy biparametric MRI used for segmentation of suspected lesions. Transperineal MTB of suspicious lesions and 12-core systematic biopsies were performed using the Artemis™ platform. CsPCa was defined as International Society of Urological Pathology grade group ≥ 2.CsPCa was detected in 192 men (62.1%), with detection rates of 6.3% for PI-RADS 2, 26.8% for PI-RADS 3, 87.3% for PI-RADS 4, and 93.1% for PI-RADS 5. MTB of the index lesion identified 185 csPCa (96.3%). CsPCa was detected solely in systematic biopsies in three cases (1.6%), while an additional four cases (2.1%) were identified only in the second suspected lesion. A predictive model for csPCa detection in MTB of the index lesion was developed, with an AUC of 0.918 (95% CI 0.887-0.950).This model had the potential to avoid 23.3% of prostate biopsies without missing additional csPCa cases. MTB of the index lesion was highly effective for identifying csPCa in fusion transperineal prostate biopsies. A developed predictive model successfully reduced the need for almost one quarter of biopsies without missing csPCa cases. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| ISSN: | 1677-6119 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2023.0558 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38446907 https://hdl.handle.net/11351/12569 https://doaj.org/article/0cfd9d77f698472d9917f7a6071c4479 https://ddd.uab.cat/record/306826 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....0e66d2c45e21908dac414b61092c5003 |
| Database: | OpenAIRE |
| ISSN: | 16776119 16775538 |
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| DOI: | 10.1590/s1677-5538.ibju.2023.0558 |