Bibliographic Details
| Title: |
Association of serum vitamin D levels and dietary vitamin D intake with latent tuberculosis infection and long-term mortality: a population-based cohort study |
| Authors: |
Wei Hsu, Ming-Yan Jiang |
| Source: |
BMJ Nutrition, Prevention & Health, Vol, Iss |
| Publisher Information: |
BMJ, 2025. |
| Publication Year: |
2025 |
| Subject Terms: |
RC620-627, Nutritional diseases. Deficiency diseases |
| Description: |
Background Vitamin D plays a crucial role in immune function and respiratory infections, yet its association with latent tuberculosis infection (LTBI) and long-term mortality remains unclear. This study investigates the relationship between serum 25-hydroxyvitamin D levels, dietary vitamin D intake, LTBI risk and mortality. Method We analysed data from the 2011–2012 cycle of the US National Health and Nutrition Examination Survey, including 5286 adults (≥18 years) who underwent tuberculosis (TB) testing. Serum 25-hydroxyvitamin D levels were measured using high-performance liquid chromatography–tandem mass spectrometry, and dietary vitamin D intake was assessed via a 24-hour dietary recall. LTBI was defined as an induration>10 mm on the Tuberculin Skin Test or a positive QuantiFERON-TB Gold-In-Tube test. Mortality data were obtained through linkage with the National Death Index, with follow-up until 31 December 2019. Results Among 5286 participants, 708 (13.4%) had LTBI. Individuals with LTBI had significantly lower serum 25-hydroxyvitamin D levels than those without LTBI. A 10 nmol/L increase in serum 25-hydroxyvitamin D was associated with a 5% lower risk of LTBI (adjusted OR: 0.95, 95% CI: 0.92 to 0.99, p Conclusion Vitamin D deficiency was associated with an increased risk of LTBI and long-term mortality in this population-based study. Although adequate serum 25-hydroxyvitamin D levels were linked to more favourable outcomes, the role of vitamin D supplementation in individuals with TB infection remains uncertain. Further research is needed to clarify these associations and guide evidence-based supplementation strategies for TB prevention and management. |
| Document Type: |
Article |
| Language: |
English |
| ISSN: |
2516-5542 |
| DOI: |
10.1136/bmjnph-2025-001213 |
| Access URL: |
https://doaj.org/article/c744daeb4dc14e21b1f6258ea75073b4 |
| Rights: |
CC BY NC |
| Accession Number: |
edsair.doi.dedup.....0648803da1f4dd16acbc34d53e6d47cc |
| Database: |
OpenAIRE |