Conference
Conditions of AgNPs/flavin mononucleotide complex formation as a tool to tune optical properties of this complex
| Title: | Conditions of AgNPs/flavin mononucleotide complex formation as a tool to tune optical properties of this complex |
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| Authors: | Dushina, Anastasiya, Stepanov, Maxim, Arzhanov, Artem, Khaydukov, Evgeniy, Generalova, Alla |
| Publisher Information: | St. Petersburg State Polytechnical University Journal. Physics and Mathematics, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | optical properties, silver nanoparticles, рибофлавин, lumichrome, наночастицы серебра, оптические свойства, люмихром, фотодеградация, riboflavin, photodegradation, flavin mononucleotide, флавинмононуклеотид |
| Description: | Recently, photodynamic therapy has been considered as one of the promising alternatives to classical antimicrobial therapy based on antibiotics, which has become less effective due to bacterial resistance. Flavin mononucleotide (FMN), a vitamin B2 derivative, is a biocompatible, affordable drug with attractive photodynamic properties, including the generation of reactive oxygen species (ROS) that can target and disrupt bacteria. The integration of silver nanoparticles, known for their antibacterial properties, could affect photochemical processes and potentially enhance the antimicrobial effectiveness of FMN. This study shows the results of an investigation into the conditions for the formation of a complex between silver nanoparticles and FMN, as well as the influence of nano-sized silver on the photodegradation of FMN under light irradiation. This work presents the development of a method aimed at preparation of FMN-silver nanoparticles complex. The influence of silver nanoparticles on the fluorescent properties of FMN and the dynamics of its photodegradation was evaluated. Фотодинамическая терапия на основе флавинмононуклеотида (ФМН) рассматривается как перспективная альтернатива антибиотикам, поскольку ФМН является доступным лекарственным средством с привлекательными фотосенсибилизирующими свойствами. Добавление наночастиц серебра, известных своими антибактериальными свойствами, может повлиять на протекание фотохимических процессов и потенциально усилить противомикробную эффективность ФМН. В данной работе представлены результаты исследования условий формирования комплекса наночастиц серебра и ФМН, а также влияния наноразмерного серебра на фотодеградацию ФМН. |
| Document Type: | Conference object |
| Language: | English |
| DOI: | 10.18721/jpm.173.261 |
| Accession Number: | edsair.doi...........c15b659c5845d1f7c15fa343b365ae08 |
| Database: | OpenAIRE |
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