Bibliographic Details
| Title: |
Keyora Framework of Phospholipids, Choline, Phosphatidylcholine, Phospholipid-Bound Omega-3s, and Astaxanthin: Cognitive, Cardiometabolic, Hepatic, Ocular, Reproductive, and Anti-Inflammatory Support |
| Authors: |
Jin, Xu |
| Publisher Information: |
OSF, 2025. |
| Publication Year: |
2025 |
| Subject Terms: |
Eye Diseases, Mitochondrial protection, Joint recovery, Sports Sciences, Diseases, Choline, Male Urogenital Diseases, Medicine and Health Sciences, Pregnancy nutrition, Nutritional Epidemiology, Inflammation resolution, Immunology and Infectious Disease, Neuroscience and Neurobiology, Mental and Social Health, Life Sciences, Other Neuroscience and Neurobiology, Lipids, Immunoprophylaxis and Therapy, Chemicals and Drugs, Phospholipid, DPA-PC, Immune System Diseases, Cardiovascular Diseases, ChoBioavailabilityline, Community Health, DHA-PC, Menopause, Dietetics and Clinical Nutrition, Human and Clinical Nutrition, Anti-thrombotic effect, Endothelial repair, Digestive System Diseases, Gallstone prevention, Other Nutrition, Dry eye, Substance Abuse and Addiction, Krill oil, Endocrine System Diseases, Phospholipid-bound Omega-3s, Specialized pro-resolving mediators, Alternative and Complementary Medicine, Muscle protection, Blood-brain barrier penetration, NAFLD, Other Medicine and Health Sciences, Nutrition, International and Community Nutrition, Astaxanthin, EPA-PC, Atherosclerosis, Synaptic function, Phosphatidylcholine, Reverse cholesterol transport, Nutritional and Metabolic Diseases, Dyslipidemia, Other Life Sciences, Angiogenesis, Nervous System Diseases |
| Description: |
This project, grounded in the Keyora Phospholipid–Omega Framework, investigates the integrative role of phospholipid-bound omega-3 fatty acids - via Antarctic krill oil, phosphatidylcholine-conjugated EPA/DHA, and docosapentaenoic acid (DPA) - in the regulation of cognitive, cardiovascular, metabolic, and systemic health. Unlike traditional triglyceride or ethyl ester forms, phospholipid-bound omega-3s exhibit superior absorption, direct membrane incorporation, and efficient blood–brain barrier penetration, ensuring enhanced bioavailability and targeted delivery. Mechanistically, these lipids provide broad physiological benefits: 1. Neurocognitive Support: DHA-PC crosses the blood–brain barrier to sustain synaptic integrity, neurotransmission, and mood stability, while DPA improves cerebral microcirculation and contributes to neuroinflammation resolution. 2. Cardiovascular and Metabolic Regulation: EPA/DHA-PC improve lipid profiles, reduce triglycerides, inhibit LDL oxidation, and modulate vascular tone. DPA provides unique angiogenic and antithrombotic effects, supporting endothelial repair and reverse cholesterol transport. 3. Hepatic Function: Phosphatidylcholine enables VLDL assembly and triglyceride export, preventing fatty liver progression and maintaining bile acid homeostasis. 4. Anti-inflammatory and Antioxidant Defense: Omega-3-derived specialized pro-resolving mediators and DPA-exclusive lipid mediators accelerate inflammation resolution, while astaxanthin enhances mitochondrial resilience and suppresses oxidative stress. 5. Reproductive and Systemic Health: Omega-3 phospholipids and DPA improve sperm motility, support female hormonal balance and fetal neurodevelopment, and enhance resilience in high-demand physical and cognitive states. Together, this phospholipid–omega-3–astaxanthin matrix addresses three major nutritional gaps of modern diets - insufficient choline, low omega-3 intake, and inadequate antioxidant defense. Its multi-dimensional benefits span cognition, cardiovascular and hepatic health, immune modulation, reproductive capacity, ocular protection, and recovery, offering a safe and highly bioavailable strategy for long-term health optimization across diverse populations |
| Document Type: |
Article |
| Language: |
English |
| DOI: |
10.17605/osf.io/z8mwc |
| Rights: |
CC BY |
| Accession Number: |
edsair.doi...........3c655ef0f89f2e952838e17c5b22ea69 |
| Database: |
OpenAIRE |