Academic Journal
Metabolic flux control enhances intracellular biosynthesis of fumagillin derivatives in human cells.
| Τίτλος: | Metabolic flux control enhances intracellular biosynthesis of fumagillin derivatives in human cells. |
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| Συγγραφείς: | Matsuda, Shinya1 (AUTHOR) |
| Πηγή: | Bioscience, Biotechnology & Biochemistry. Jul2026, Vol. 90 Issue 7, p919-922. 4p. |
| Θεματικοί όροι: | Cytochrome P-450, Biosynthesis, Metabolites, Natural products, Cytotoxins, Endothelial cells, Human cell culture, Metabolic flux analysis |
| Περίληψη: | Intracellular biosynthesis of natural products in human cells represents a promising strategy for functional drug delivery. Here, we engineered the production of fumagillin metabolites in human cells expressing fungal cytochrome P450 Fma-P450. In endothelial-derived EA.hy926 cells, metabolic flux optimization enhanced metabolite production and enabled detection of cytotoxic activity. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: | Supplemental Index |
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