Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Metabolic flux control enhances intracellular biosynthesis of fumagillin derivatives in human cells. |
| Συγγραφείς: |
Matsuda, Shinya1 (AUTHOR) |
| Πηγή: |
Bioscience, Biotechnology & Biochemistry. Jul2026, Vol. 90 Issue 7, p919-922. 4p. |
| Θεματικοί όροι: |
Cytochrome P-450, Biosynthesis, Metabolites, Natural products, Cytotoxins, Endothelial cells, Human cell culture, Metabolic flux analysis |
| Περίληψη: |
Intracellular biosynthesis of natural products in human cells represents a promising strategy for functional drug delivery. Here, we engineered the production of fumagillin metabolites in human cells expressing fungal cytochrome P450 Fma-P450. In endothelial-derived EA.hy926 cells, metabolic flux optimization enhanced metabolite production and enabled detection of cytotoxic activity. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: |
Supplemental Index |