Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Effects of Coenzyme Q10 on Rat Liver Cells under Conditions of Metabolic Stress. |
| Συγγραφείς: |
Vasiliev, A. V., Martinova, E. A., Sharanova, N. V., Gapparov, M. M. |
| Πηγή: |
Bulletin of Experimental Biology & Medicine; Feb2011, Vol. 150 Issue 4, p416-419, 4p, 4 Charts, 2 Graphs |
| Θεματικοί όροι: |
Coenzymes, Liver cells, Metabolic syndrome, Psychological stress, Rats |
| Περίληψη: |
Under conditions of metabolic stress induced in Wistar rats by 5-day starvation with subsequent refeeding, supplementation with coenzyme Q10 in doses of 10 and 100 μg/kg of body weight resulted in significant increase in liver weight after the experiment. Percent ratio of liver cell populations was changed, which was detected by flow cytometry. In addition, specific effects of low dose of coenzyme Q10 (10 mg/kg body weight) on hepatocytes was observed, which manifested in increased number of mitoses and percentage of S-phase cells, enhanced expression of D1 and Rb-protein expression, and reduced percent of apoptotic hepatocytes. Adaptive effects of coenzyme Q10 are associated with enhanced expression of Hsp25, Hsp70, and Hsp90 in hepatocytes during metabolic stress. [ABSTRACT FROM AUTHOR] |
|
Copyright of Bulletin of Experimental Biology & Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Βάση Δεδομένων: |
Complementary Index |