Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Effect of Dietary Anti-Urease Immunoglobulin Y onHelicobacter pyloriInfection in Mongolian Gerbils. |
| Συγγραφείς: |
Nomura, Sachiko, Suzuki, Hidekazu, Masaoka, Tatsuhiro, Kurabayashi, Kumiko, Ishii, Hiromasa, Kitajima, Masaki, Nomoto, Kikuo, Hibi, Toshifumi |
| Πηγή: |
Helicobacter; Feb2005, Vol. 10 Issue 1, p43-52, 10p |
| Θεματικοί όροι: |
Gerbils, Helicobacter pylori infections, Immunoglobulins, Gastritis, Peptic ulcer, Gastrointestinal diseases |
| Περίληψη: |
Helicobacter pyloriis known to be a major pathogenic factor in the development of gastritis, peptic ulcer disease and gastric cancer. Recently, chicken egg yolk immunoglobulin Y (IgY) has been recognized as an inexpensive antibody source for passive immunization against gastrointestinal infections. The present study was designed to investigate the effect of anti-urease IgY onH. pyloriinfection in Mongolian gerbils.H. pylori-infected Mongolian gerbils were administered a diet containing anti-urease IgY, with or without famotidine (F). After 10 weeks, bacterial culture and measurement of the gastric mucosal myeloperoxidase (MPO) activity were performed. In a second experiment, another group of gerbils was started on a diet containing F + IgY a week prior toH. pyloriinoculation. After 9 weeks, these animals were examined.In theH. pylori-infected gerbils, there were no significant differences in the level ofH. pyloricolonization among the different dietary and control groups. However, the MPO activity was significantly decreased in theH. pylorigroup administered the F + IgY diet compared with that in theH. pylorigroup administered the IgY, F, or control diet. Furthermore, in the gerbils administered the F + IgY diet prior to the bacterial inoculation, inhibition ofH. pyloricolonization and suppression of the elevated gastric mucosal MPO activity were observed.Oral administration of urease-specific IgY not only inhibitedH. pyloridisease activity inH. pylori-infected gerbils, but also preventedH. pyloricolonization in those not yet infected. These encouraging results may pave the way for a novel therapeutic and prophylactic approach in the management ofH. pylori-associated gastroduodenal disease. [ABSTRACT FROM AUTHOR] |
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| Βάση Δεδομένων: |
Complementary Index |