Academic Journal
Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats.
| Τίτλος: | Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats. |
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| Συγγραφείς: | Hybertson BM; Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, USA. HYBERTSO@ESSEX.HSC.COLORADO.EDU, Leff JA, Beehler CJ, Barry PC, Repine JE |
| Πηγή: | Free radical biology & medicine [Free Radic Biol Med] 1995 Mar; Vol. 18 (3), pp. 537-42. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print Cited Medium: Print ISSN: 0891-5849 (Print) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| Ιατρικοί όροι (MeSH): | Lung Injury*, Vitamin E/*administration & dosage , Vitamin E Deficiency/*complications, Free Radicals/metabolism ; Interleukin-1/toxicity ; Lung/drug effects ; Lung/metabolism ; Peroxidase/metabolism ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/prevention & control ; Vitamin E/pharmacokinetics ; Vitamin E Deficiency/drug therapy ; Vitamin E Deficiency/metabolism ; Adult ; Aerosols ; Animals ; Diet ; Humans ; Male ; Oxidation-Reduction ; Rats ; Rats, Sprague-Dawley |
| Περίληψη: | We hypothesized that alterations in lung vitamin E levels would impact the development of acute oxidative lung injury. We found that dietary induced deficiency of vitamin E diminished lung tissue levels of vitamin E and increased lung leak following intratracheal administration of interleukin-1 (IL-1) to rats. Conversely, rats administered vitamin E directly to the lungs as an inhaled aerosol (0.3-3 microns particles) formed by supercritical fluid aerosolization (SFA) had increased lung tissue vitamin E levels and decreased IL-1 induced lung leak compared to control rats. Lung myeloperoxidase (MPO) activities, reflecting neutrophil concentrations, were increased in rats given IL-1 intratracheally compared to rats given saline intratracheally but were not different for control or vitamin E depleted rats. Lung MPO activities in rats given IL-1 intratracheally were slightly higher in SFA vitamin E treated rats than in control rats. Our results suggest that vitamin E levels affect susceptibility to IL-1 induced, neutrophil-dependent lung injury. We speculate that supercritical fluid aerosol (SFA) delivery of vitamin E can rapidly increase lung vitamin E levels and decrease acute oxidative lung injury. |
| Grant Information: | HL 07085 United States HL NHLBI NIH HHS; SCOR 40784 United States SC NCI NIH HHS |
| Substance Nomenclature: | 0 (Aerosols) 0 (Free Radicals) 0 (Interleukin-1) 1406-18-4 (Vitamin E) EC 1.11.1.7 (Peroxidase) |
| Entry Date(s): | Date Created: 19950301 Date Completed: 19970708 Latest Revision: 20201209 |
| Update Code: | 20260130 |
| DOI: | 10.1016/0891-5849(94)00180-r |
| PMID: | 9101244 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 0891-5849 |
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| DOI: | 10.1016/0891-5849(94)00180-r |