Academic Journal
Lambda-cyhalothrin and male reproductive dysfunction: neurotoxicity, hypogonadism, erectile dysfunction, and infertility.
| Τίτλος: | Lambda-cyhalothrin and male reproductive dysfunction: neurotoxicity, hypogonadism, erectile dysfunction, and infertility. |
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| Συγγραφείς: | Cretu AM; Origyn Fertility Center, Iași, Romania.; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iași, Romania., Kamar AAM; Department Biology, Faculty of Biology, Doctoral School, Alexandru Ioan Cuza University, Iași, Romania., Ciobica A; Origyn Fertility Center, Iași, Romania.; Department Biology, Faculty of Biology, Alexandru Ioan Cuza University (UAIC), Iași, Romania., Puia D; Origyn Fertility Center, Iași, Romania.; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iași, Romania.; Department of Urology, 'Dr. C.I. Parhon' Clinical Hospital, Iași, Romania., Doroftei M; Origyn Fertility Center, Iași, Romania.; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iași, Romania., Doroftei B; Origyn Fertility Center, Iași, Romania.; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iași, Romania.; Spitalul Clinic de Obstetrică și Ginecologie 'Cuza Vodă', Iași, Romania. |
| Πηγή: | Frontiers in public health [Front Public Health] 2026 Oct 02; Vol. 14, pp. 1956109. Date of Electronic Publication: 2026 Oct 02 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Editorial Office |
| Ιατρικοί όροι (MeSH): | Pyrethrins*/toxicity , Pyrethrins*/adverse effects , Infertility, Male*/chemically induced , Nitriles*/toxicity , Nitriles*/adverse effects , Erectile Dysfunction*/chemically induced , Insecticides*/toxicity , Insecticides*/adverse effects , Hypogonadism*/chemically induced , Neurotoxicity Syndromes*/etiology, Environmental Exposure/adverse effects ; Male ; Humans ; Animals |
| Περίληψη: | Lambda-cyhalothrin is one of the most widely used type II pyrethroid insecticides in agriculture, public health programs, and domestic pest control. Although their acute toxicity in humans is generally considered low, concerns have been raised regarding their potential effects on male reproductive function. Male infertility affects a substantial proportion of couples worldwide, and environmental exposures have been proposed as contributing factors. This review critically examines the available evidence linking lambda-cyhalothrin exposure to male reproductive dysfunction. Experimental studies have reported adverse effects on neurotoxicity, reproductive hormone regulation, testicular function, spermatogenesis, and sperm quality following lambda-cyhalothrin exposure. Human studies have identified associations between urinary pyrethroid metabolites and reduced semen quality, altered reproductive hormones, and sperm DNA damage. However, the available epidemiological evidence remains limited and heterogeneous. Current findings indicate that lambda-cyhalothrin may adversely affect male reproductive function through neurotoxicity, endocrine disruption, oxidative stress, impaired testicular function, and sperm damage. While the biological plausibility of these effects is supported by experimental data, the extent of their contribution to infertility in exposed human populations remains uncertain. Unlike previous reviews, this review proposes an integrated neuroendocrine framework linking central, autonomic, and peripheral neurotoxicity with hypothalamic-pituitary-gonadal axis dysfunction, hypogonadism, erectile dysfunction, and male infertility following lambda-cyhalothrin exposure. This integrated perspective highlights important evidence gaps and may guide future experimental, occupational, epidemiological, and clinical research. (Copyright © 2026 Cretu, Kamar, Ciobica, Puia, Doroftei and Doroftei.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: endocrine disruption; erectile dysfunction; lambda-cyhalothrin; male hypogonadism; male infertility; neurotoxicity |
| Substance Nomenclature: | 0 (Pyrethrins) V0V73PEB8M (cyhalothrin) 0 (Nitriles) 0 (Insecticides) |
| Entry Date(s): | Date Created: 20261017 Date Completed: 20261017 Latest Revision: 20261017 |
| Update Code: | 20261018 |
| PubMed Central ID: | PMC13674087 |
| DOI: | 10.3389/fpubh.2026.1956109 |
| PMID: | 42890696 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2296-2565 |
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| DOI: | 10.3389/fpubh.2026.1956109 |