Academic Journal
High levels of domestic transmission and drug resistance -analysis of national surveillance data for shigellosis, the Netherlands, 2018 to 2024.
| Τίτλος: | High levels of domestic transmission and drug resistance -analysis of national surveillance data for shigellosis, the Netherlands, 2018 to 2024. |
|---|---|
| Συγγραφείς: | van der Putten B; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.; ECDC Fellowship Programme, Public Health Microbiology path (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden., Sauskojus H; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.; ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden., Meijs A; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Notermans D; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Lanzl M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Franz E; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., van den Beld M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Pijnacker R; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands. |
| Συλλογικό Έργο: | ISIS-AR study group; The members of the ISIS-AR group are listed under Acknowledgements. |
| Πηγή: | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2026 Oct; Vol. 31 (41). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: European Centre for Disease Prevention and Control (ECDC) Country of Publication: Sweden NLM ID: 100887452 Publication Model: Print Cited Medium: Internet ISSN: 1560-7917 (Electronic) Linking ISSN: 1025496X NLM ISO Abbreviation: Euro Surveill Subsets: MEDLINE |
| Imprint Name(s): | Publication: Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC) Original Publication: Saint-Maurice : Hôpital national de Saint-Maurice |
| Ιατρικοί όροι (MeSH): | Dysentery, Bacillary*/epidemiology , Dysentery, Bacillary*/transmission , Dysentery, Bacillary*/drug therapy , Dysentery, Bacillary*/microbiology , Shigella*/isolation & purification , Shigella*/genetics , Shigella*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Population Surveillance* , Drug Resistance, Bacterial*, Netherlands/epidemiology ; Humans ; Male ; Incidence ; Female ; Adult ; Middle Aged ; Aged ; Adolescent ; Child, Preschool ; Infant ; Young Adult ; Microbial Sensitivity Tests ; Child ; Infant, Newborn ; Drug Resistance, Multiple, Bacterial |
| Περίληψη: | BACKGROUNDAntimicrobial resistance (AMR) among Shigella species is increasing, which is concerning. Strengthening surveillance is key to obtaining accurate, timely and actionable data on shigellosis.AIMWe aimed to describe Dutch national shigellosis surveillance data from 2018 to 2024, spanning the implementation of national genomic surveillance in 2022.METHODSWe described notified shigellosis cases and used logistic regression models to analyse associations between shigellosis and age, sex, year of infection, province, MSM (men who have sex with men) association, travel status, severity of disease and Shigella species.RESULTSIn 2018-2024, 3,020 shigellosis cases were notified. Incidence of shigellosis decreased during the COVID-19 pandemic years 2020-2021 but returned to pre-pandemic incidence in 2023 and 2024. Most cases were males (n = 1,887; 62.5%). Of the 1,731 cases with available data, 732 (42.3%) reported recent contact with MSM, representing 24.2% of all shigellosis cases. The proportion of extensive drug resistant (XDR) isolates increased from 2018 (1/58) to 2023 (24/109; 22.0%) (p < 0.001). Cases were more likely to be part of a cluster if they reported a recent MSM contact (p < 0.001) or harboured an XDR isolate (p < 0.001). Cases with recent MSM contact were more likely to harbour an XDR strain (p < 0.001).CONCLUSIONImplementation of genomic surveillance facilitated detection of clusters, provided more timely data on AMR and allowed for more detailed analyses of risk factors for Shigella transmission. Continued intervention efforts promoting hygiene and raising awareness on shigellosis and AMR are important to curb the increase of XDR shigellosis. |
| References: | Epidemiol Infect. 2024 Oct 22;152:e130. (PMID: 39434376) Antimicrob Agents Chemother. 2020 Sep 21;64(10):. (PMID: 32718957) Microorganisms. 2021 Apr 06;9(4):. (PMID: 33917583) Genome Res. 2020 Jan;30(1):138-152. (PMID: 31809257) Lancet Microbe. 2022 Jul;3(7):e481. (PMID: 35779565) Am J Infect Control. 2025 Apr;53(4):524-526. (PMID: 39667596) Lancet Infect Dis. 2023 Jun;23(6):732-739. (PMID: 36731481) Emerg Infect Dis. 2025 Jul;31(7):1394-1405. (PMID: 40562732) Antimicrob Agents Chemother. 2020 Nov 17;64(12):. (PMID: 33020158) Aust N Z J Public Health. 2019 Feb;43(1):41-45. (PMID: 30516310) Microb Genom. 2023 Apr;9(4):. (PMID: 37022322) Int J Antimicrob Agents. 2021 Sep;58(3):106378. (PMID: 34157402) Nat Commun. 2023 Apr 8;14(1):1983. (PMID: 37031199) J Antimicrob Chemother. 2020 Jul 1;75(7):1820-1823. (PMID: 32221592) Euro Surveill. 2017 Nov;22(46):. (PMID: 29162208) J Infect Dis. 2025 Jun 2;231(5):1176-1185. (PMID: 39611769) Lancet Glob Health. 2019 Mar;7(3):e321-e330. (PMID: 30784633) Epidemiol Infect. 2013 Aug;141(8):1625-39. (PMID: 23013659) Lancet. 2018 Feb 24;391(10122):801-812. (PMID: 29254859) mBio. 2021 Jan 26;12(1):. (PMID: 33500335) Lancet Infect Dis. 2023 Jun;23(6):740-750. (PMID: 36731480) Microb Genom. 2025 Mar;11(3):. (PMID: 40048496) Nat Commun. 2023 Jan 28;14(1):462. (PMID: 36709320) Epidemiol Infect. 2024 Oct 04;152:e115. (PMID: 39363593) J Antimicrob Chemother. 2021 Dec 24;77(1):89-97. (PMID: 34673959) |
| Contributed Indexing: | Keywords: Shigellosis; antimicrobial resistance; surveillance; the Netherlands; whole-genome sequencing |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20261016 Date Completed: 20261016 Latest Revision: 20261019 |
| Update Code: | 20261019 |
| PubMed Central ID: | PMC13675696 |
| DOI: | 10.2807/1560-7917.ES.2026.31.41.2600075 |
| PMID: | 42885490 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1560-7917 |
|---|---|
| DOI: | 10.2807/1560-7917.ES.2026.31.41.2600075 |