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Comparative RP-HPTLC Lipophilicity Analysis of Bioactive 1,3,4-Thiadiazole-Resorcinol Conjugates.

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Τίτλος: Comparative RP-HPTLC Lipophilicity Analysis of Bioactive 1,3,4-Thiadiazole-Resorcinol Conjugates.
Συγγραφείς: Paw B; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego St. 4, 20-090 Lublin, Poland., Studziński M; Department of Physical Chemistry, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland., Stec S; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego St. 4, 20-090 Lublin, Poland., Barańska K; Independent Radiopharmacy Unit, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland., Malinowska I; Department of Physical Chemistry, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland., Matysiak J; Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland.
Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Sep 25; Vol. 27 (19). Date of Electronic Publication: 2026 Sep 25.
Τύπος έκδοσης: Journal Article; Comparative Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI, [2000-
Ιατρικοί όροι (MeSH): Thiadiazoles*/chemistry , Resorcinols*/chemistry , Chromatography, Reverse-Phase*/methods, Chromatography, Thin Layer/methods ; Chromatography, High Pressure Liquid/methods ; Hydrophobic and Hydrophilic Interactions
Περίληψη: The behavior of bioactive 1,3,4-thiadiazoles of anticancer potency and cholinesterases (ChEs) inhibitors was examined by high-performance thin-layer chromatography (HPTLC) in a reversed phase (RP) system. The chromatographic systems consisted of C-18 or C-8-bonded silica as the stationary phase and binary mixtures of water with methanol, acetonitrile, acetone, or dioxane as the mobile phase. The lipophilicity parameters RMw (the RM value of a solute extrapolated to pure water as the mobile phase) were determined based on the linear relationship between compound retention and water content in the mobile phase. RMw parameters obtained from various chromatographic systems were analyzed both in relation to each other and compared with other lipophilicity parameters, including log kw values obtained by RP-18 HPLC and computationally calculated log P. Descriptive, correlation and principal component analyses were applied. The applicability of the HPTLC method for assessing the lipophilicity of 1,3,4-thiadiazole-resorcinol conjugates was demonstrated based on the log kw values determined by HPLC according to the OECD-recommended procedure and described previously. The correlation coefficients (r) between the RMw parameters for these systems and log kw (C-18) is ≥0.81, whereas for the C-8 stationary phases RMw versus log kw is ≥0.95. Taking into account the results of descriptive and correlation analysis, the C18 stationary phase with methanol as the organic modifier and the C8 stationary phase with methanol or dioxan as the organic modifier were found to be the most suitable chromatographic systems for lipophilicity determination of bioactive compounds.
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Contributed Indexing: Keywords: 1,3,4-thiadiazole-resorcinols; HPTLC; RP-18; RP-8; correlation analysis; lipophilicity; organic modifier
Substance Nomenclature: 0 (Thiadiazoles)
0 (Resorcinols)
14IAC3GH7G (1,3,4-thiadiazole)
YUL4LO94HK (resorcinol)
Entry Date(s): Date Created: 20261016 Date Completed: 20261016 Latest Revision: 20261020
Update Code: 20261020
PubMed Central ID: PMC13665130
DOI: 10.3390/ijms27198561
PMID: 42883808
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1422-0067
DOI:10.3390/ijms27198561