Academic Journal
Low-carbohydrate diets improved glucose homeostasis and physical performance by regulating mitochondrial function via the SIRT3/PGC1α pathway.
| Τίτλος: | Low-carbohydrate diets improved glucose homeostasis and physical performance by regulating mitochondrial function via the SIRT3/PGC1α pathway. |
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| Συγγραφείς: | Li T; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China.; The Fourth Affiliated Hospital of Soochow University, Department of Rehabilitation Medicine, Suzhou 215000, Jiangsu, China., Wang X; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China., Lu H; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China., Chen M; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China., Zhang H; Shandong Public Health Clinical Center, Department of Rehabilitation Medicine, Jinan 250132, Shandong, China., Zhang M; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China., Sun Z; Shandong Second Medical University, School of Rehabilitation Medicine, Weifang 261053, Shandong, China. |
| Πηγή: | Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2026 Oct 12; Vol. 98 (4), pp. e20251367. Date of Electronic Publication: 2026 Oct 12 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Rio De Janeiro : Academia Brasileira De Ciencias |
| Ιατρικοί όροι (MeSH): | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/metabolism , Sirtuin 3*/metabolism , Blood Glucose*/metabolism , Mitochondria*/metabolism , Mitochondria*/physiology , Glucose*/metabolism , Diet, Carbohydrate-Restricted*, Homeostasis/physiology ; Muscle, Skeletal/metabolism ; Animals ; Mice, Inbred C57BL ; Male ; Mice ; Random Allocation ; Body Weight |
| Περίληψη: | This study aimed to analyze the effects of two low-carbohydrate diets (LCDs) on glucose homeostasis and physical performance in sedentary mice. Eighteen C57BL/6J mice were randomly divided into three groups: fed with standard chow (CON), high-fat LCD chow (HF-LCD), and high-protein LCD chow (HP-LCD). After two weeks, body weight (BW), food intake, fasting serum ketone bodies (β-OHB), blood glucose, glucose tolerance, and relative mass of skeletal muscle were measured. The physical performance was assessed using a treadmill endurance test, and the mRNA levels of mitochondrial function (SIRT3 and PGC1α) in the quadriceps were measured by qRT-PCR. Compared with the CON group, the HF-LCD group showed significantly increased fat content, β-OHB, and physical performance; the HP-LCD group showed significantly decreased calorie intake and BW. Compared with the HF-LCD group, the HP-LCD group showed significantly lower calorie intake, BW, fat content, β-OHB, skeletal muscle mass, and physical performance. Mechanistically, the mRNA levels of SIRT3-PGC1α in the HF-LCD group were higher than those in the other group. Both short-term LCDs can maintain glucose homeostasis in mice. However, only HF-LCD can increase β-OHB and physical performance without compromising skeletal muscle mass and strength. The underlying mechanism may involve transcriptional regulation of mitochondrial‑related genes via the SIRT3/PGC1α pathway. |
| Substance Nomenclature: | 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) EC 3.5.1.- (Sirtuin 3) 0 (Blood Glucose) 0 (Ppargc1a protein, mouse) 0 (Sirt3 protein, mouse) IY9XDZ35W2 (Glucose) |
| Entry Date(s): | Date Created: 20261015 Date Completed: 20261015 Latest Revision: 20261015 |
| Update Code: | 20261016 |
| DOI: | 10.1590/0001-3765202620251367 |
| PMID: | 42879576 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1678-2690 |
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| DOI: | 10.1590/0001-3765202620251367 |