Academic Journal
Considering evolved heat tolerance helps predict the immunological consequences of climate change.
| Τίτλος: | Considering evolved heat tolerance helps predict the immunological consequences of climate change. |
|---|---|
| Συγγραφείς: | Lucore JM; Department of Anthropology, University of Michigan, Ann Arbor, MI, USA. jlucore@umich.edu., Marshall AJ; Department of Anthropology, University of Michigan, Ann Arbor, MI, USA.; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA.; Program in the Environment, University of Michigan, Ann Arbor, MI, USA.; School for Environment and Sustainability, University of Michigan, Ann Arbor, MI, USA.; Program in Computing for the Arts and Sciences, University of Michigan, Ann Arbor, MI, USA. |
| Πηγή: | Seminars in immunopathology [Semin Immunopathol] 2026 Oct 13; Vol. 48 (1). Date of Electronic Publication: 2026 Oct 13. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 101308769 Publication Model: Electronic Cited Medium: Internet ISSN: 1863-2300 (Electronic) Linking ISSN: 18632297 NLM ISO Abbreviation: Semin Immunopathol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer |
| Ιατρικοί όροι (MeSH): | Thermotolerance*/immunology , Climate Change* , Biological Evolution*, Hot Temperature/adverse effects ; Immune System/metabolism ; Humans ; Animals ; Adaptation, Physiological |
| Περίληψη: | Among the most damaging anticipated consequences of climate change are rising global temperatures that are expected to exceed the heat tolerance of many species worldwide. Species' heat tolerance reflects adaptation to their historical environments, and rapid increases in ambient temperatures create a mismatch between evolved thermal tolerance and present-day heat exposures. This mismatch has severe implications because high temperatures can disrupt physiological processes across levels of biological organization. The immune system, specifically, may be particularly susceptible to dysregulation under climate warming because it is highly responsive to temperature. Although a rich body of empirical and clinical research has characterized the effects of heat on immunity, these findings are rarely interpreted in the context of evolved heat tolerance. Here, we provide a framework for predicting the immunological consequences of climate change by integrating results derived from five decades of immune research with evolutionary principles of heat tolerance. This framework offers a strong foundation for predicting the health and disease consequences of immune vulnerability to heat in a rapidly warming world. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
| References: | Oecologia. 2016 May;181(1):77-85. (PMID: 26846428) Endocr Rev. 2000 Feb;21(1):55-89. (PMID: 10696570) Mucosal Immunol. 2017 Jan;10(1):18-26. (PMID: 27554295) Biochem Soc Trans. 2023 Apr 26;51(2):735-745. (PMID: 37013978) Semin Immunol. 2018 Dec;40:17-35. (PMID: 30287177) Ann N Y Acad Sci. 2007 Oct;1113:40-51. (PMID: 17656573) Sci Rep. 2021 Oct 28;11(1):21272. (PMID: 34711864) Animal. 2010 Jul;4(7):1167-83. (PMID: 22444615) Behav Med. 1992 Fall;18(3):115-20. (PMID: 1330102) Dev Comp Immunol. 2018 Jul;84:273-278. (PMID: 29510163) Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1274-1279. (PMID: 29358381) Annu Rev Immunol. 2002;20:125-63. (PMID: 11861600) Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1531-8. (PMID: 11049833) Animal. 2014 Sep;8(9):1462-8. (PMID: 24912383) DNA Cell Biol. 2007 Aug;26(8):619-26. (PMID: 17688414) Int J Hyperthermia. 2013 Aug;29(5):423-35. (PMID: 23863046) Science. 2002 Jun 21;296(5576):2158-62. (PMID: 12077394) Cell Stress Chaperones. 1997 Mar;2(1):60-71. (PMID: 9250396) Science. 2011 Aug 19;333(6045):1024-6. (PMID: 21852500) J Leukoc Biol. 2007 May;81(5):1179-87. (PMID: 17311933) Am J Primatol. 2022 May;84(4-5):e23300. (PMID: 34223656) Eur J Immunol. 2014 May;44(5):1552-62. (PMID: 24470107) Infect Immun. 1977 Jun;16(3):947-54. (PMID: 19356) Comp Biochem Physiol A Mol Integr Physiol. 2019 Nov;237:110542. (PMID: 31419577) J Therm Biol. 2020 Jul;91:102615. (PMID: 32716865) Comp Biochem Physiol A Mol Integr Physiol. 2002 Aug;132(4):739-61. (PMID: 12095860) Nat Rev Immunol. 2017 Apr;17(4):233-247. (PMID: 28192415) Arch Intern Med. 1999 Nov 8;159(20):2430-6. (PMID: 10665891) Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349) Mitochondrion. 2021 Jul;59:225-245. (PMID: 33839318) Nature. 2000 Nov 9;408(6809):239-47. (PMID: 11089981) Science. 2008 Oct 10;322(5899):261-4. (PMID: 18845755) Annu Rev Genet. 1988;22:631-77. (PMID: 2853609) Children (Basel). 2014 Nov 11;1(3):403-23. (PMID: 27417487) R Soc Open Sci. 2020 Feb 12;7(2):191825. (PMID: 32257339) Int J Hyperthermia. 2023;40(1):2179672. (PMID: 36813265) Nat Ecol Evol. 2020 Aug;4(8):1044-1059. (PMID: 32451428) Brain Behav Immun. 2002 Apr;16(2):104-17. (PMID: 11908921) J Immunol. 2003 Dec 1;171(11):5736-42. (PMID: 14634081) Med Hypotheses. 2006;67(3):609-17. (PMID: 16631316) Int J Biometeorol. 2021 Jul;65(7):1231-1244. (PMID: 33496873) J Biol Chem. 1984 Oct 10;259(19):11882-9. (PMID: 6384217) Molecules. 2018 Nov 01;23(11):. (PMID: 30388847) Integr Comp Biol. 2016 Jul;56(1):98-109. (PMID: 27126981) Neuroimmunomodulation. 2009;16(5):300-17. (PMID: 19571591) Science. 2007 Jan 5;315(5808):95-7. (PMID: 17204649) Proc Biol Sci. 2015 Dec 22;282(1821):20143085. (PMID: 26702035) Biomed Res Int. 2013;2013:160859. (PMID: 24151582) Cell Host Microbe. 2017 Feb 8;21(2):208-219. (PMID: 28182951) Neurosci Biobehav Rev. 2023 Sep;152:105238. (PMID: 37225063) Exp Biol Med (Maywood). 2017 Feb;242(3):258-266. (PMID: 27798118) Lancet. 1995 Nov 4;346(8984):1194-6. (PMID: 7475659) Mol Cell. 2025 Oct 16;85(20):3874-3889. (PMID: 41106375) J Exp Med. 2016 May 2;213(5):697-713. (PMID: 27091841) Front Vet Sci. 2022 Jul 13;9:918036. (PMID: 35909690) Science. 2008 Jun 6;320(5881):1296-7. (PMID: 18535231) Science. 2002 Apr 12;296(5566):301-5. (PMID: 11951032) Proc Natl Acad Sci U S A. 2019 May 21;116(21):10333-10338. (PMID: 31064871) Trends Immunol. 2003 Aug;24(8):444-8. (PMID: 12909458) Neurobiol Learn Mem. 2009 Sep;92(2):215-24. (PMID: 18667167) Infect Immun. 1976 Aug;14(2):496-501. (PMID: 971959) Immune Netw. 2018 Aug 13;18(4):e27. (PMID: 30181915) Proc Biol Sci. 2000 Apr 22;267(1445):739-45. (PMID: 10819141) Eur J Appl Physiol. 2020 Apr;120(4):897-905. (PMID: 32088743) Semin Cell Dev Biol. 2001 Dec;12(6):449-57. (PMID: 11735379) Eur Cytokine Netw. 2007 Sep;18(3):154-61. (PMID: 17823084) Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7231-5. (PMID: 9618568) Front Microbiol. 2020 Mar 10;11:384. (PMID: 32210948) Nat Rev Immunol. 2005 Mar;5(3):243-51. (PMID: 15738954) J Exp Biol. 2012 Mar 15;215(Pt 6):922-33. (PMID: 22357586) Infect Immun. 1977 Dec;18(3):673-9. (PMID: 412788) Gut Microbes. 2012 Jul-Aug;3(4):289-306. (PMID: 22572875) Clin Transl Immunology. 2016 Apr 22;5(4):e73. (PMID: 27195116) Physiol Behav. 1982 Sep;29(3):509-13. (PMID: 7178257) Genes Dev. 1992 Aug;6(8):1402-13. (PMID: 1644286) Am J Phys Anthropol. 2009 Jan;138(1):101-11. (PMID: 18711741) Ecol Lett. 2013 Sep;16(9):1206-19. (PMID: 23869696) Vaccines (Basel). 2022 Oct 17;10(10):. (PMID: 36298601) Environ Sci Pollut Res Int. 2020 Jun;27(18):22336-22352. (PMID: 32347486) Proc Biol Sci. 2011 Jun 22;278(1713):1823-30. (PMID: 21106582) Sci Adv. 2024 Nov 29;10(48):eadq6629. (PMID: 39612329) Comp Biochem Physiol A Mol Integr Physiol. 2002 Mar;131(3):475-83. (PMID: 11867273) Int J Biometeorol. 2020 May;64(5):853-861. (PMID: 32036432) Immunity. 2013 Sep 19;39(3):482-95. (PMID: 23993650) Int J Dermatol. 2020 Mar;59(3):265-278. (PMID: 31970754) Ann N Y Acad Sci. 2002 Jun;966:290-303. (PMID: 12114286) Animal. 2012 May;6(5):707-28. (PMID: 22558920) Scand J Immunol. 1981;13(2):159-74. (PMID: 7015485) Ann N Y Acad Sci. 1998 May 1;840:803-8. (PMID: 9629306) Nat Commun. 2021 Feb 19;12(1):1198. (PMID: 33608528) Nat Rev Immunol. 2017 Jun;17(6):363-375. (PMID: 28393922) Science. 2004 Jul 30;305(5684):626-9. (PMID: 15286356) Exerc Immunol Rev. 2007;13:100-11. (PMID: 18198664) Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2513099122. (PMID: 41123997) Immunity. 2024 Apr 9;57(4):752-771. (PMID: 38599169) Cell Stress Chaperones. 2000 Nov;5(5):471-80. (PMID: 11189454) Nat Rev Immunol. 2015 Jun;15(6):335-49. (PMID: 25976513) J Anim Sci. 2019 Jan 1;97(1):122-132. (PMID: 30346551) Inflamm Res. 2025 Nov 26;74(1):173. (PMID: 41296074) Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2119872119. (PMID: 35858416) Discov Immunol. 2024 Jan 30;3(1):kyae001. (PMID: 38567294) J Immunol. 2009 Apr 15;182(8):4965-73. (PMID: 19342676) Trends Immunol. 2011 Feb;32(2):89-95. (PMID: 21145789) Ann N Y Acad Sci. 2000 Jun;908:244-54. (PMID: 10911963) Interdiscip Perspect Infect Dis. 2009;2009:593232. (PMID: 19277106) J Anim Ecol. 2011 Jul;80(4):710-30. (PMID: 21401591) Eur J Appl Physiol. 2008 Mar;102(4):391-401. (PMID: 17962974) Int J Hyperthermia. 2014 Nov;30(7):513-23. (PMID: 25354680) Biology (Basel). 2024 Mar 09;13(3):. (PMID: 38534449) Brain Behav Immun. 1998 Mar;12(1):64-73. (PMID: 9570862) Handb Clin Neurol. 2018;156:193-209. (PMID: 30454590) Microbes Infect. 2000 Dec;2(15):1891-904. (PMID: 11165933) Mol Cell. 2010 Oct 22;40(2):253-66. (PMID: 20965420) Res Vet Sci. 2019 Oct;126:94-102. (PMID: 31445399) Nat Clim Chang. 2022;12(9):869-875. (PMID: 35968032) Ecol Lett. 2016 Nov;19(11):1372-1385. (PMID: 27667778) Annu Rev Biochem. 1986;55:1151-91. (PMID: 2427013) Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov;139(3):321-33. (PMID: 15544958) J Biol Chem. 2002 Apr 26;277(17):15028-34. (PMID: 11836257) Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H509-21. (PMID: 11158946) Biomed Res Int. 2017;2017:9351507. (PMID: 29230419) Comp Biochem Physiol A Mol Integr Physiol. 2001 Jun;129(2-3):417-31. (PMID: 11423314) Annu Rev Physiol. 1999;61:243-82. (PMID: 10099689) Cell Stress Chaperones. 2014 May;19(3):389-400. (PMID: 24085588) Zool Res. 2019 Jul 18;40(4):305-316. (PMID: 31310064) |
| Contributed Indexing: | Keywords: Climate change; Evolutionary framework; Heat tolerance; Immune system; Immunity; Thermal limits |
| Entry Date(s): | Date Created: 20261013 Date Completed: 20261013 Latest Revision: 20261016 |
| Update Code: | 20261016 |
| PubMed Central ID: | PMC13661744 |
| DOI: | 10.1007/s00281-026-01082-z |
| PMID: | 42867638 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1863-2300 |
|---|---|
| DOI: | 10.1007/s00281-026-01082-z |