Academic Journal
Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review.
| Τίτλος: | Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review. |
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| Συγγραφείς: | Yadav S; Department of Zoology, IIS (deemed to be) University, Jaipur, Rajasthan, India., John PJ; Department of Zoology, IIS (deemed to be) University, Jaipur, Rajasthan, India. |
| Πηγή: | Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2026 Oct; Vol. 40 (10), pp. e71128. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Wiley, c1998- |
| Ιατρικοί όροι (MeSH): | Infertility, Male*/chemically induced , Infertility, Male*/prevention & control , Infertility, Male*/metabolism , Testis*/metabolism , Testis*/pathology , Testis*/drug effects , Environmental Pollutants*/toxicity , Reproduction*/drug effects, Oxidative Stress/drug effects ; DNA Damage/drug effects ; Spermatogenesis/drug effects ; Antioxidants/therapeutic use ; Humans ; Male ; Animals |
| Περίληψη: | The male reproductive system is highly vulnerable to environmental toxicants, particularly potentially toxic elements (PTEs), which represent a growing public health concern worldwide. Increasing evidence indicates that these elements impair male reproductive function through interconnected mechanisms including oxidative stress, endocrine disruption, inflammation, apoptosis, and DNA damage, resulting in impaired spermatogenesis and infertility. This review summarizes the current understanding of the major PTEs associated with male reproductive toxicity and highlights the underlying cellular and molecular mechanisms responsible for testicular injury. In addition, it discusses emerging protective and therapeutic strategies, including antioxidants, phytochemicals, nutraceuticals, chelating agents and lifestyle-based interventions that have shown potential in mitigating PTE-induced reproductive damage. A comprehensive understanding of these mechanisms and protective approaches may facilitate the development of effective preventive and therapeutic strategies to preserve male reproductive health in populations exposed to PTEs. (© 2026 The Author(s). Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.) |
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| Grant Information: | 09/1180(22368)/2025-EMR-I Council of Scientific and Industrial Research, India |
| Contributed Indexing: | Keywords: male infertility; nutraceuticals; oxidative stress; testicular injury |
| Substance Nomenclature: | 0 (Antioxidants) 0 (Environmental Pollutants) |
| Entry Date(s): | Date Created: 20261012 Date Completed: 20261012 Latest Revision: 20261014 |
| Update Code: | 20261014 |
| PubMed Central ID: | PMC13655493 |
| DOI: | 10.1002/jbt.71128 |
| PMID: | 42860776 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1099-0461 |
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| DOI: | 10.1002/jbt.71128 |