Academic Journal
Effect of photon radiotherapy on microleakage and microhardness of nanohybrid resin composite restoration: an in vitro study.
| Title: | Effect of photon radiotherapy on microleakage and microhardness of nanohybrid resin composite restoration: an in vitro study. |
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| Authors: | Khedr MA; Biomaterials Department, Faculty of Dentistry, Assiut University, Assiut, Egypt. manarahmhassan@dent.aun.edu.eg., Hussien YF; Biomaterials Department, Faculty of Dentistry, Minia University, Minia, 61511, Egypt., Hashem MA; South Egypt Cancer Institute, Radiation Oncology and Nuclear Medicine Department, Assiut University, Assiut, Egypt., Gamal R; Biomaterials Department, Faculty of Dentistry, Minia University, Minia, 61511, Egypt. |
| Source: | BMC oral health [BMC Oral Health] 2026 Oct 08; Vol. 26 (1). Date of Electronic Publication: 2026 Oct 08. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| MeSH Terms: | Composite Resins*/radiation effects , Composite Resins*/chemistry , Dental Leakage*/etiology , Dental Restoration, Permanent*/methods , Nanocomposites*/radiation effects , Nanocomposites*/chemistry , Photons*, Hardness/radiation effects ; Animals ; Cattle ; In Vitro Techniques ; Materials Testing ; Random Allocation |
| Abstract: | Background: Photon radiotherapy (RT) is widely used in the management of head and neck cancer (HNC) and may affect dental restorative materials. However, limited evidence is available regarding its effects on nanohybrid resin composite (RC) restorations. This research aimed to assess the impact of photon radiation treatment on microleakage (ML) and microhardness (MH) of nanohybrid RC restorations. Methods: A total of 54 samples were randomly divided into three groups (18 sample each): a control group (non-irradiated) and two RT groups exposed to 50 Gy (Gy) and 70 Gy of photon radiation. The radiation doses were delivered as a single dose, and post-irradiation assessments were performed immediately after irradiation. For ML, 30 extracted bovine incisors (n = 10 per group) were standardized, prepared with Class V cavities, and restored using a nanohybrid RC (Grandio, VOCO GmbH, Germany). Microleakage was assessed by dye penetration at the restoration interface using a stereomicroscope. For MH, 24 disc shaped composite samples (n = 8 per group) were evaluated using the Vickers MH test. Results: The median ML scores were 1.0, 1.0, and 2.0 for groups I, II, III, respectively (p = 0.029), while the median ML percentages were 17.93%, 24.75%, and 46.71%, respectively (p = 0.003). Before irradiation, mean MH values were 52.39 ± 2.41, 52.53 ± 1.51, and 52.23 ± 2.03, respectively (p = 0.959). Immediately after irradiation, these values increased to 53.60 ± 1.09, 62.90 ± 3.09, and 72.20 ± 5.53, respectively (p < 0.001). Conclusions: Under the conditions of this in vitro study, photon RT was associated with increased ML at 70 Gy of nanohybrid RC, whereas MH significantly increased following irradiation at both 50 and 70 Gy. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethical approval and consent to participate: This study was approved by the Research Ethics Committee, Faculty of Dentistry, Minia University (Approval No. 824/2023). Not applicable, as this in vitro study did not involve human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Marginal integrity; Microleakage; Nanohybrid Resin composite; Photon Radiotherapy; Vickers microhardness |
| Substance Nomenclature: | 0 (Composite Resins) |
| Entry Date(s): | Date Created: 20261010 Date Completed: 20261010 Latest Revision: 20261012 |
| Update Code: | 20261012 |
| PubMed Central ID: | PMC13653397 |
| DOI: | 10.1186/s12903-026-09873-4 |
| PMID: | 42859164 |
| Database: | MEDLINE |
| ISSN: | 1472-6831 |
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| DOI: | 10.1186/s12903-026-09873-4 |