Academic Journal
The mitochondrial epigenome and noncoding genome in aging and brain diseases.
| Τίτλος: | The mitochondrial epigenome and noncoding genome in aging and brain diseases. |
|---|---|
| Συγγραφείς: | Shawky AA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; National Institutes of Health/National Cancer Institute, Bethesda, MD 20892, USA., Huang HT; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Parikh D; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Emory University, Atlanta, GA 30322, USA., Morris-Blanco KC; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: Kahlilia.blanco@pennmedicine.upenn.edu. |
| Πηγή: | Trends in neurosciences [Trends Neurosci] 2026 Oct 10. Date of Electronic Publication: 2026 Oct 10. |
| Publication Model: | Ahead of Print |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Publishing Country of Publication: England NLM ID: 7808616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-108X (Electronic) Linking ISSN: 01662236 NLM ISO Abbreviation: Trends Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Elsevier Applied Science Publishing Original Publication: Amsterdam, New York, Elsevier/North-Holland Biomedical Press. |
| Περίληψη: | The mitochondrial genome is a dynamic regulatory platform that extends far beyond its protein-coding capacity. Mitochondrial DNA (mtDNA) harbors epigenetic modifications and produces diverse noncoding RNAs that influence mitochondrial function and cellular homeostasis. Evidence from animal models and human studies indicates that mtDNA methylation, mitochondrial-encoded noncoding RNAs, and cytosolic release of mitochondrial nucleic acids regulate transcription, metabolism, and stress signaling. Furthermore, these mechanisms are altered in aging, neurodegenerative disease, and acute brain injury. In this review, we synthesize emerging insights into how the mitochondrial epigenome and noncoding genome shape mitochondrial function and serve as regulatory interfaces linking cellular stress and neuronal vulnerability in brain aging and disease. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no conflicts of interest. |
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| Grant Information: | T32 HL007915 United States HL NHLBI NIH HHS |
| Contributed Indexing: | Keywords: DNA methylation; double-stranded RNA; long noncoding RNAs; mecciRNAs; mitochondrial epigenetics; neurodegenerative disease |
| Entry Date(s): | Date Created: 20261010 Latest Revision: 20261014 |
| Update Code: | 20261014 |
| PubMed Central ID: | PMC13660430 |
| DOI: | 10.1016/j.tins.2026.09.007 |
| PMID: | 42859082 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-108X |
|---|---|
| DOI: | 10.1016/j.tins.2026.09.007 |