Reconsidering the health-related burden of mental and physical disorders in the presence of comorbidity: evidence from China Mental Health Survey.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Reconsidering the health-related burden of mental and physical disorders in the presence of comorbidity: evidence from China Mental Health Survey.
Συγγραφείς:	Huang J; Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing, China., Zhang T; Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing, China., Yu Y; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Xu X; Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Wang Z; Department of Epidemiology and Statistics, School of Public Health and Management, Ningxia Medical University, Yinchuan, China., Xu Y; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China., Li T; Mental Health Centre, West China Hospital, Sichuan University, Chengdu, China., Xu G; Department of Social Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China., Xu X; Department of Psychiatry, The Fourth People's Hospital in Urumqi, Urumqi, China., Wang L; National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC, Beijing, China., Yan Y; Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China., Li L; Mental Health Institute, the Second Xiangya Hospital, Central-south University, Changsha, China., Yan J; Institute of Social Science Survey, Peking University, Beijing, China., Liu Z; Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing, China., Xiao S; Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha, China., Huang Y; Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing, China.
Πηγή:	Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2026 Oct 10; Vol. 35, pp. e68. Date of Electronic Publication: 2026 Oct 10.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Cambridge University Press Country of Publication: England NLM ID: 101561091 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-7979 (Electronic) Linking ISSN: 20457960 NLM ISO Abbreviation: Epidemiol Psychiatr Sci Subsets: MEDLINE
Imprint Name(s):	Original Publication: Cambridge : Cambridge University Press
Ιατρικοί όροι (MeSH):	Mental Disorders/epidemiology , Mental Disorders/psychology , Major Depressive Disorder/epidemiology , Major Depressive Disorder/psychology , Bipolar Disorder/epidemiology , Cost of Illness, China/epidemiology ; Generalized Anxiety Disorder/epidemiology ; Humans ; Comorbidity ; Female ; Male ; Cross-Sectional Studies ; Adult ; Health Surveys ; Middle Aged ; Prevalence ; Young Adult ; Adolescent ; Aged ; Health Status ; Mental Health ; Self Report
Περίληψη:	Aims: Mental and physical disorders are leading contributors to global disability. However, estimates of their health-related burden often overlook the pervasive comorbidity among conditions. This study aimed to quantify the independent and combined effects of these disorders on self-rated health in nationally representative Chinese adults, explicitly accounting for comorbidity. Methods: Data were drawn from the China Mental Health Survey (CMHS), a cross-sectional nationally representative survey. Mental disorders were assessed using the Composite International Diagnostic Interview 3.0, and physical disorders were measured through structured self-report. Health-related burden was assessed using a 0-100 visual analogue scale (VAS) of self-rated health over the past 30 days. Nested regression models examined disorder-specific and multimorbidity effects, followed by interaction-based counterfactual simulations to estimate disorder-specific burden net of comorbidity at individual and population levels. Results: Among 27,505 respondents included in multivariate analyses, comorbidity was highly prevalent. In crude models, all 20 disorders were associated with lower VAS scores, with the largest decrements observed for mental disorders such as generalized anxiety disorder (GAD), bipolar disorder and major depressive disorder (MDD). After accounting for disorder type and comorbidity structure, many associations were attenuated and the independent effect of disorder count became non-significant. Counterfactual simulations showed the largest individual-level burdens for GAD (-14.71), cancer (-9.02), bipolar disorder (-8.59) and MDD (-8.53). At the population level, insomnia symptoms (-1.56), arthritis (-0.81) and cardiovascular disorders (-0.64) contributed the greatest burden. Conclusions: Accounting for comorbidity substantially alters estimates of disorder-specific health burden. Mental disorders impose the greatest impairment at the individual level, whereas prevalent physical conditions dominate population burden.
Grant Information:	2012BAI01B01,2015BAI13B00 Ministry of Science and Technology of the People's Republic of China; CFH2024-2G-4113 Beijing Municipal Health Commission
Contributed Indexing:	Keywords: Composite International Diagnostic Interview; bipolar disorder; comorbidity; counterfactual simulation; disease burden; generalized anxiety disorder; major depressive disorder; mental disorder; physical disorder
Entry Date(s):	Date Created: 20261010 Date Completed: 20261010 Latest Revision: 20261010
Update Code:	20261011
DOI:	10.1017/S2045796026101036
PMID:	42858455
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	2045-7979
DOI:	10.1017/S2045796026101036