Academic Journal
Are Current Lipid Guidelines Adequate for South Asian Patients? A Narrative Review.
| Τίτλος: | Are Current Lipid Guidelines Adequate for South Asian Patients? A Narrative Review. |
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| Συγγραφείς: | Fernando K; Medical Research Institute, Borella, Sri Lanka.; NK Ceylon Institute of Medical Research, Negombo, Sri Lanka., De Silva S; Faculty of Medicine, University of Kelaniya, Sri Lanka.; Colombo North Teaching Hospital, Ragama, Sri Lanka. |
| Πηγή: | Global heart [Glob Heart] 2026 Oct 08; Vol. 21 (1), pp. 72. Date of Electronic Publication: 2026 Oct 08 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Ubiquity Press Country of Publication: England NLM ID: 101584391 Publication Model: eCollection Cited Medium: Internet ISSN: 2211-8179 (Electronic) Linking ISSN: 22118160 NLM ISO Abbreviation: Glob Heart Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : [London] : Ubiquity Press Original Publication: [Oxford] : Elsevier Ltd. |
| Ιατρικοί όροι (MeSH): | Cardiovascular Diseases*/ethnology , Cardiovascular Diseases*/blood , Cardiovascular Diseases*/prevention & control , Lipids*/blood , Practice Guidelines as Topic*, Risk Assessment/methods ; Humans ; South Asian People ; Asia, Southern |
| Περίληψη: | South Asians, who account for nearly one quarter of the world's population, experience a disproportionately high burden of atherosclerotic cardiovascular disease (ASCVD), often presenting 5-10 years earlier than European populations. This review evaluates whether contemporary lipid-management frameworks adequately address cardiovascular risk in South Asians. South Asians exhibit a distinct lipid phenotype characterised by elevated apolipoprotein B (ApoB), hypertriglyceridaemia, reduced HDL-cholesterol (HDL-C), increased small dense LDL (sdLDL) particles, and a high prevalence of elevated lipoprotein(a) (Lp(a)), features that are incompletely captured by conventional LDL-cholesterol (LDL-C)-based approaches. Existing cardiovascular risk tools show variable performance in South Asian populations, while contemporary guidelines differ substantially in risk assessment, LDL-cholesterol targets, incorporation of risk enhancers, and use of coronary artery calcium (CAC) scoring. Although recent guideline updates increasingly acknowledge South Asian ethnicity as a risk modifier, important gaps in calibration and implementation remain. Greater harmonisation of recommendations and validation of South Asian-specific risk assessment strategies are needed to improve cardiovascular prevention. (Copyright: © 2026 The Author(s).) |
| Competing Interests: | The authors have no competing interests to declare. |
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| Contributed Indexing: | Keywords: PREVENT equations; South Asian; apolipoprotein B; cardiovascular risk; coronary artery calcium; lipid guidelines; lipoprotein(a); risk stratification |
| Substance Nomenclature: | 0 (Lipids) |
| Entry Date(s): | Date Created: 20261010 Date Completed: 20261010 Latest Revision: 20261013 |
| Update Code: | 20261013 |
| PubMed Central ID: | PMC13651774 |
| DOI: | 10.5334/gh.1590 |
| PMID: | 42857687 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2211-8179 |
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| DOI: | 10.5334/gh.1590 |